(46 nodes) Protein localization to chromosome network (Ficedula albicollis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BUB1B	Uncharacterized protein. (1090 aa)
	U3JEG7_FICAL	Uncharacterized protein. (491 aa)
	KNL1	Knl1_RWD_C domain-containing protein. (152 aa)
	NIPBL	Nipped-B protein. (2777 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1238 aa)
	RCC2	Regulator of chromosome condensation 2. (359 aa)
	MTBP	MDM2 binding protein. (861 aa)
	TTK	TTK protein kinase. (880 aa)
	TERF2	Telomeric repeat binding factor 2. (621 aa)
	PLK1	Polo like kinase 1. (508 aa)
	LEMD2	LEM domain containing 2. (300 aa)
	BUB3	BUB3 mitotic checkpoint protein. (329 aa)
	IFFO1	Intermediate filament family orphan 1; Belongs to the intermediate filament family. (386 aa)
	ZNF827	Zinc finger protein 827. (1071 aa)
	ZW10	Zw10 kinetochore protein. (777 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (615 aa)
	WAPL	WAPL cohesin release factor. (1196 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1116 aa)
	ATR	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2657 aa)
	ACD	Uncharacterized protein. (93 aa)
	U3JXI7_FICAL	Uncharacterized protein. (343 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1105 aa)
	TPP1	Tripeptidyl peptidase 1. (509 aa)
	RB1	RB transcriptional corepressor 1. (924 aa)
	BRCA2	BRCA2 DNA repair associated. (3362 aa)
	TASOR	Transcription activation suppressor. (1023 aa)
	SLF2	Uncharacterized protein. (546 aa)
	PARP3	Poly [ADP-ribose] polymerase. (530 aa)
	SLF1	SMC5-SMC6 complex localization factor 1. (914 aa)
	KNTC1	Kinetochore associated 1. (2218 aa)
	LRWD1	Leucine rich repeats and WD repeat domain containing 1. (750 aa)
	SPDL1	Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (607 aa)
	PPHLN1	Periphilin 1. (377 aa)
	IFFO2	Intermediate filament family orphan 2; Belongs to the intermediate filament family. (375 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (386 aa)
	MAU2	MAU2 sister chromatid cohesion factor. (550 aa)
	ATRX	ATRX chromatin remodeler. (2368 aa)
	PINX1	PIN2 (TERF1) interacting telomerase inhibitor 1. (356 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (851 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
	ZWILCH	Zwilch kinetochore protein. (597 aa)
	XRCC4	X-ray repair cross complementing 4. (250 aa)
	MACROH2A2	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	U3KK86_FICAL	Uncharacterized protein. (269 aa)
	CHAMP1	Chromosome alignment maintaining phosphoprotein 1. (989 aa)
	MIS12	MIS12 kinetochore complex component. (206 aa)

Your Current Organism:

Ficedula albicollis

NCBI taxonomy Id: 59894
Other names: F. albicollis, collared flycatcher

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	TERT	ENSFALP00000007487	ENSFALP00000002239	Uncharacterized protein.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.765
ATR	BRCA2	ENSFALP00000007352	ENSFALP00000008821	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	BRCA2 DNA repair associated.	0.521
ATR	MSH2	ENSFALP00000007352	ENSFALP00000011634	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.672
ATR	RPA1	ENSFALP00000007352	ENSFALP00000006871	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.980
ATR	SLF1	ENSFALP00000007352	ENSFALP00000009467	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	SMC5-SMC6 complex localization factor 1.	0.989
ATR	SPO11	ENSFALP00000007352	ENSFALP00000011295	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	SPO11 initiator of meiotic double stranded breaks.	0.692
ATR	TERT	ENSFALP00000007352	ENSFALP00000002239	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.548
ATR	U3JEG7_FICAL	ENSFALP00000007352	ENSFALP00000001171	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.553
ATRX	BRCA2	ENSFALP00000011372	ENSFALP00000008821	ATRX chromatin remodeler.	BRCA2 DNA repair associated.	0.520
ATRX	MACROH2A2	ENSFALP00000011372	ENSFALP00000013789	ATRX chromatin remodeler.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.417
ATRX	NIPBL	ENSFALP00000011372	ENSFALP00000002138	ATRX chromatin remodeler.	Nipped-B protein.	0.485
ATRX	TERT	ENSFALP00000011372	ENSFALP00000002239	ATRX chromatin remodeler.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.472
BRCA2	ATR	ENSFALP00000008821	ENSFALP00000007352	BRCA2 DNA repair associated.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.521
BRCA2	ATRX	ENSFALP00000008821	ENSFALP00000011372	BRCA2 DNA repair associated.	ATRX chromatin remodeler.	0.520
BRCA2	BUB1B	ENSFALP00000008821	ENSFALP00000001087	BRCA2 DNA repair associated.	Uncharacterized protein.	0.441
BRCA2	MSH2	ENSFALP00000008821	ENSFALP00000011634	BRCA2 DNA repair associated.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.772
BRCA2	PARP3	ENSFALP00000008821	ENSFALP00000009211	BRCA2 DNA repair associated.	Poly [ADP-ribose] polymerase.	0.669
BRCA2	PLK1	ENSFALP00000008821	ENSFALP00000003937	BRCA2 DNA repair associated.	Polo like kinase 1.	0.920
BRCA2	RPA1	ENSFALP00000008821	ENSFALP00000006871	BRCA2 DNA repair associated.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.594
BRCA2	SLF1	ENSFALP00000008821	ENSFALP00000009467	BRCA2 DNA repair associated.	SMC5-SMC6 complex localization factor 1.	0.701