STRINGSTRING
CDS2 CDS2 MTMR2 MTMR2 DGKI DGKI PIK3C2A PIK3C2A INPP5B INPP5B PPIP5K2 PPIP5K2 PLCZ1 PLCZ1 PLCB2 PLCB2 DGKQ DGKQ INPP5A INPP5A INPP5E INPP5E INPP5F INPP5F DGKE DGKE PRKCA PRKCA ITPK1 ITPK1 SACM1L SACM1L PIP5K1B PIP5K1B DGKG DGKG PIKFYVE PIKFYVE PRKCB PRKCB IP6K3 IP6K3 ITPR3 ITPR3 ITPR2 ITPR2 PIK3CB PIK3CB PLCD4 PLCD4 U3JNI7_FICAL U3JNI7_FICAL INPP4B INPP4B PIP4P2 PIP4P2 CDS1 CDS1 PLCG1 PLCG1 ITPKA ITPKA DGKZ DGKZ IMPA2 IMPA2 PLCD1 PLCD1 PLCG2 PLCG2 MTMR3 MTMR3 PIP4K2A PIP4K2A PIK3CD PIK3CD PLCE1 PLCE1 PI4KA PI4KA DGKH DGKH IP6K2 IP6K2 PIK3CA PIK3CA PI4K2A PI4K2A IMPA1 IMPA1 MTMR6 MTMR6 PIK3C3 PIK3C3 IP6K1 IP6K1 IPPK IPPK PI4K2B PI4K2B PIK3R3 PIK3R3 LOC101820005 LOC101820005 PIK3R1 PIK3R1 DGKB DGKB CALML4 CALML4 IMPAD1 IMPAD1 PLCB1 PLCB1 PI4KB PI4KB PLCB4 PLCB4 MTMR8 MTMR8 MTMR7 MTMR7 PPIP5K1 PPIP5K1 ITPKB ITPKB OCRL OCRL DGKK DGKK MTM1 MTM1 MTMR1 MTMR1 CALM1 CALM1 SYNJ2 SYNJ2 MTMR14 MTMR14 CALM2 CALM2 PTEN PTEN IPMK IPMK PIP4K2B PIP4K2B INPP5D INPP5D ITPR1 ITPR1 MTMR4 MTMR4 PIK3R2 PIK3R2 CALML3 CALML3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDS2Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (450 aa)
MTMR2Myotubularin related protein 2. (571 aa)
DGKIDiacylglycerol kinase. (926 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1700 aa)
INPP5BInositol polyphosphate-5-phosphatase B. (810 aa)
PPIP5K2Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1250 aa)
PLCZ1Phosphoinositide phospholipase C. (639 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
DGKQDiacylglycerol kinase. (845 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (430 aa)
INPP5EInositol polyphosphate-5-phosphatase E. (654 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (948 aa)
DGKEDiacylglycerol kinase. (523 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa)
ITPK1Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (369 aa)
SACM1LSAC1 like phosphatidylinositide phosphatase. (484 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (545 aa)
DGKGDiacylglycerol kinase. (875 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2117 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
IP6K3Kinase; Belongs to the inositol phosphokinase (IPK) family. (464 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2692 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
PLCD4Phosphoinositide phospholipase C. (753 aa)
U3JNI7_FICALSH2 domain-containing protein. (914 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (923 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (222 aa)
CDS1Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (374 aa)
PLCG1Phosphoinositide phospholipase C. (1155 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (408 aa)
DGKZDiacylglycerol kinase. (988 aa)
IMPA2Inositol-1-monophosphatase. (276 aa)
PLCD1Phosphoinositide phospholipase C. (797 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
MTMR3Myotubularin related protein 3. (1204 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (370 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
PLCE1Phosphoinositide phospholipase C. (2328 aa)
PI4KAPhosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2045 aa)
DGKHDiacylglycerol kinase. (1080 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (428 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PI4K2API3K/PI4K domain-containing protein. (417 aa)
IMPA1Inositol-1-monophosphatase. (278 aa)
MTMR6Myotubularin related protein 6. (622 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (882 aa)
IP6K1Kinase; Belongs to the inositol phosphokinase (IPK) family. (431 aa)
IPPKInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (491 aa)
PI4K2BPhosphatidylinositol 4-kinase type 2 beta. (405 aa)
PIK3R3Uncharacterized protein. (753 aa)
LOC1018200051-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1295 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
DGKBDiacylglycerol kinase. (814 aa)
CALML4Calmodulin like 4. (120 aa)
IMPAD1Inositol monophosphatase domain containing 1. (230 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1124 aa)
PI4KBPhosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (731 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
MTMR8Myotubularin related protein 8. (627 aa)
MTMR7Myotubularin related protein 7. (658 aa)
PPIP5K1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1443 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (507 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (738 aa)
DGKKDiacylglycerol kinase. (1148 aa)
MTM1Myotubularin 1. (602 aa)
MTMR1Myotubularin related protein 1. (676 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
SYNJ2Synaptojanin 2. (1451 aa)
MTMR14Myotubularin related protein 14. (595 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (369 aa)
IPMKKinase; Belongs to the inositol phosphokinase (IPK) family. (420 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (366 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1214 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2762 aa)
MTMR4Myotubularin related protein 4. (1133 aa)
PIK3R2Uncharacterized protein. (727 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
Your Current Organism:
Ficedula albicollis
NCBI taxonomy Id: 59894
Other names: F. albicollis, collared flycatcher
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.