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SIAH1 SIAH1 CCNE1 CCNE1 SESN3 SESN3 MDM4 MDM4 ATM ATM RCHY1 RCHY1 CCND1 CCND1 TP53I3 TP53I3 CCND2 CCND2 FAM76A FAM76A CCND3 CCND3 SIVA1 SIVA1 CDKN1A CDKN1A TSC2 TSC2 CASP8 CASP8 U3JNE7_FICAL U3JNE7_FICAL GADD45G GADD45G EI24 EI24 CHEK1 CHEK1 THBS1 THBS1 PPM1D PPM1D BCL2L1 BCL2L1 CCNE2 CCNE2 RRM2B RRM2B RRM2 RRM2 ATR ATR FAS FAS COP1 COP1 CHEK2 CHEK2 ZMAT3 ZMAT3 CCNG2 CCNG2 IGF1 IGF1 U3K4K5_FICAL U3K4K5_FICAL TP73 TP73 BID BID GTSE1 GTSE1 MDM2 MDM2 CDK6 CDK6 PIDD1 PIDD1 APAF1 APAF1 U3KA53_FICAL U3KA53_FICAL CASP3 CASP3 SESN1 SESN1 LOC101808612 LOC101808612 CD82 CD82 CCNB2 CCNB2 LOC101816892 LOC101816892 LOC101817073 LOC101817073 BCL2 BCL2 SERPINB5 SERPINB5 PTEN PTEN IGFBP3 IGFBP3 AIFM2 AIFM2 CDK1 CDK1 CCNG1 CCNG1 STEAP3 STEAP3 SFN SFN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (407 aa)
SESN3Sestrin 3. (433 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (476 aa)
ATMNon-specific serine/threonine protein kinase. (3066 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (261 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
TP53I3Tumor protein p53 inducible protein 3. (341 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (285 aa)
FAM76AFamily with sequence similarity 76 member A. (244 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (307 aa)
SIVA1Uncharacterized protein. (80 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (147 aa)
TSC2TSC complex subunit 2. (1798 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (507 aa)
U3JNE7_FICALUncharacterized protein; Belongs to the peptidase C14A family. (468 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
EI24EI24 autophagy associated transmembrane protein. (343 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
THBS1Thrombospondin 1. (1136 aa)
PPM1DProtein phosphatase, Mg2+/Mn2+ dependent 1D. (448 aa)
BCL2L1BCL2 like 1. (230 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (404 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (371 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (397 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2657 aa)
FASFas cell surface death receptor. (369 aa)
COP1COP1 E3 ubiquitin ligase. (609 aa)
CHEK2Checkpoint kinase 2. (522 aa)
ZMAT3Zinc finger matrin-type 3. (289 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (338 aa)
IGF1Insulin like growth factor 1. (153 aa)
U3K4K5_FICALCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (647 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (184 aa)
GTSE1G2 and S-phase expressed 1. (723 aa)
MDM2MDM2 proto-oncogene. (308 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
PIDD1P53-induced death domain protein 1. (881 aa)
APAF1Apoptotic peptidase activating factor 1. (1267 aa)
U3KA53_FICALTNFR-Cys domain-containing protein. (228 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (282 aa)
SESN1Sestrin 1. (470 aa)
LOC101808612Uncharacterized protein. (429 aa)
CD82Tetraspanin. (265 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (400 aa)
LOC101816892Uncharacterized protein. (196 aa)
LOC101817073Uncharacterized protein. (189 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (439 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (369 aa)
IGFBP3Insulin like growth factor binding protein 3. (197 aa)
AIFM2Apoptosis inducing factor mitochondria associated 2. (373 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (302 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
STEAP3STEAP3 metalloreductase. (459 aa)
SFNStratifin; Belongs to the 14-3-3 family. (246 aa)
Your Current Organism:
Ficedula albicollis
NCBI taxonomy Id: 59894
Other names: F. albicollis, collared flycatcher
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