115 items (Ficedula albicollis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (735 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (667 aa)
	ATG101	Autophagy related 101. (236 aa)
	VAMP8	Vesicle associated membrane protein 8. (110 aa)
	IRS4	Uncharacterized protein. (977 aa)
	ATG4A	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
	RAB39B	RAB39B, member RAS oncogene family. (213 aa)
	RAB7B	RAB7B, member RAS oncogene family. (203 aa)
	BECN1	Uncharacterized protein. (407 aa)
	DAPK3	Death associated protein kinase 3; Belongs to the protein kinase superfamily. (456 aa)
	RRAS2	RAS related 2. (210 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (398 aa)
	RRAGC	Ras related GTP binding C. (364 aa)
	C9orf72	C9orf72-SMCR8 complex subunit. (481 aa)
	BNIP3	BCL2 interacting protein 3. (211 aa)
	LOC101812925	Uncharacterized protein. (214 aa)
	TSC1	TSC complex subunit 1. (1153 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (713 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (561 aa)
	ERN1	Endoplasmic reticulum to nucleus signaling 1. (971 aa)
	DEPTOR	DEP domain containing MTOR interacting protein. (397 aa)
	WIPI1	WD repeat domain, phosphoinositide interacting 1. (422 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (341 aa)
	GABARAPL2	GABA type A receptor associated protein like 2. (124 aa)
	ATG2B	Autophagy related 2B. (2077 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	RRAGD	Ras related GTP binding D. (333 aa)
	IRS2	Insulin receptor substrate 2. (1117 aa)
	LAMP1	Lysosomal associated membrane protein 1. (423 aa)
	ATG4B	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (393 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (812 aa)
	NRAS	NRAS proto-oncogene, GTPase. (156 aa)
	PRKCD	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (702 aa)
	CTSL	Uncharacterized protein; Belongs to the peptidase C1 family. (337 aa)
	DAPK1	Death associated protein kinase 1. (1430 aa)
	TSC2	TSC complex subunit 2. (1798 aa)
	MLST8	MTOR associated protein, LST8 homolog. (326 aa)
	GABARAPL1	GABA type A receptor associated protein like 1. (121 aa)
	ATG14	Autophagy related 14. (411 aa)
	KRAS	KRAS proto-oncogene, GTPase. (188 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
	CFLAR	CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (489 aa)
	IGBP1	Uncharacterized protein. (337 aa)
	ATG9A	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (817 aa)
	STX17	Syntaxin 17; Belongs to the syntaxin family. (352 aa)
	RAB33B	RAB33B, member RAS oncogene family. (228 aa)
	EIF2S1	Eukaryotic translation initiation factor 2 subunit alpha. (317 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1535 aa)
	ZFYVE1	Zinc finger FYVE-type containing 1. (716 aa)
	BCL2L1	BCL2 like 1. (230 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
	VMP1	Vacuole membrane protein 1. (406 aa)
	MAPK10	Mitogen-activated protein kinase. (426 aa)
	ATG3	Autophagy-related protein 3. (314 aa)
	ULK2	Unc-51 like autophagy activating kinase 2. (1076 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (401 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1301 aa)
	ATG13	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (549 aa)
	IRS1	Insulin receptor substrate 1. (935 aa)
	MTMR3	Myotubularin related protein 3. (1204 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	MAPK8	Mitogen-activated protein kinase. (384 aa)
	RUBCN	Rubicon autophagy regulator. (1033 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	SQSTM1	Sequestosome 1. (452 aa)
	SNAP29	Synaptosome associated protein 29. (240 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (275 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	MAPK1	Mitogen-activated protein kinase. (321 aa)
	SUPT20H	SPT20 homolog, SAGA complex component. (822 aa)
	ULK1	Unc-51 like autophagy activating kinase 1. (1115 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	HMGB1	High mobility group box 1. (215 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (882 aa)
	CAMKK2	Protein kinase domain-containing protein. (515 aa)
	PIK3R3	Uncharacterized protein. (753 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	WDR41	WD repeat domain 41. (442 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (404 aa)
	RB1CC1	RB1 inducible coiled-coil 1. (1598 aa)
	MTOR	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1153 aa)
	LOC101816087	Uncharacterized protein. (398 aa)
	DAPK2	Death associated protein kinase 2; Belongs to the protein kinase superfamily. (357 aa)
	LOC101806431	Uncharacterized protein. (248 aa)
	RRAGB	Uncharacterized protein. (367 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (396 aa)
	UVRAG	UV radiation resistance associated. (586 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	RPS6KB2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (439 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (523 aa)
	TRAF6	TNF receptor-associated factor. (471 aa)
	ATG4C	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (459 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (1361 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1330 aa)
	TP53INP2	Uncharacterized protein. (83 aa)
	DDIT4	DNA damage inducible transcript 4. (184 aa)
	MTMR14	Myotubularin related protein 14. (595 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (369 aa)
	MRAS	Muscle RAS oncogene homolog. (208 aa)
	NRBF2	Nuclear receptor binding factor 2. (298 aa)
	RAB8A	RAB8A, member RAS oncogene family. (207 aa)
	ATG16L1	Autophagy related 16 like 1. (562 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2762 aa)
	RAB1A	RAB1A, member RAS oncogene family. (213 aa)
	SMCR8	SMCR8-C9orf72 complex subunit. (939 aa)
	MTMR4	Myotubularin related protein 4. (1133 aa)
	WIPI2	WD repeat domain, phosphoinositide interacting 2. (446 aa)
	PIK3R2	Uncharacterized protein. (727 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (441 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (582 aa)

Your Current Organism:

Ficedula albicollis

NCBI taxonomy Id: 59894
Other names: F. albicollis, collared flycatcher

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT3	ENSFALP00000003094	ENSFALP00000011968	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	MAPK1	ENSFALP00000003094	ENSFALP00000008282	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.925
AKT1	MLST8	ENSFALP00000003094	ENSFALP00000003771	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	MTOR associated protein, LST8 homolog.	0.670
AKT1	MTOR	ENSFALP00000003094	ENSFALP00000010712	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.977
AKT1	PDPK1	ENSFALP00000003094	ENSFALP00000014686	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase 1.	0.989
AKT1	PIK3CA	ENSFALP00000003094	ENSFALP00000008750	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.960
AKT1	PIK3CB	ENSFALP00000003094	ENSFALP00000004251	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.957
AKT1	PIK3CD	ENSFALP00000003094	ENSFALP00000007638	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.957
AKT1	PIK3R1	ENSFALP00000003094	ENSFALP00000010272	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.954
AKT1	PIK3R2	ENSFALP00000003094	ENSFALP00000014443	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.954
AKT1	PIK3R3	ENSFALP00000003094	ENSFALP00000009923	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.954
AKT1	PPP2CA	ENSFALP00000003094	ENSFALP00000008266	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein phosphatase.	0.727
AKT1	PRKAA1	ENSFALP00000003094	ENSFALP00000002093	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.502
AKT1	PRKAA2	ENSFALP00000003094	ENSFALP00000012816	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.508
AKT1	PTEN	ENSFALP00000003094	ENSFALP00000013682	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.632
AKT1	RPS6KB1	ENSFALP00000003094	ENSFALP00000005776	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.640
AKT1	RPS6KB2	ENSFALP00000003094	ENSFALP00000012736	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.641
AKT1	RPTOR	ENSFALP00000003094	ENSFALP00000013111	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Regulatory associated protein of MTOR complex 1.	0.745
AKT1	RRAGB	ENSFALP00000003094	ENSFALP00000011746	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.633
AKT1	RRAGC	ENSFALP00000003094	ENSFALP00000001082	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Ras related GTP binding C.	0.528