STRINGSTRING
RAF1 RAF1 ADCY7 ADCY7 ADCY6 ADCY6 PRKAG1 PRKAG1 GNG10 GNG10 SLC9A1 SLC9A1 BECN1 BECN1 RRAS2 RRAS2 MAP2K2 MAP2K2 PLCB2 PLCB2 U3JF72_FICAL U3JF72_FICAL CCND1 CCND1 GNG2 GNG2 PRKAA1 PRKAA1 SLC8A1 SLC8A1 GNA13 GNA13 GABARAPL2 GABARAPL2 ADCY8 ADCY8 GNAI3 GNAI3 CDH1 CDH1 AKT1 AKT1 RPS6 RPS6 GNG13 GNG13 GNAQ GNAQ EGR1 EGR1 NRAS NRAS GABARAPL1 GABARAPL1 PRKAB2 PRKAB2 HDAC4 HDAC4 KRAS KRAS ITPR3 ITPR3 ITPR2 ITPR2 PRKAG3 PRKAG3 ADCY9 ADCY9 GNB3 GNB3 LOC101816985 LOC101816985 NOS2 NOS2 SLC8A3 SLC8A3 SPP1 SPP1 MYL3 MYL3 MYLK2 MYLK2 RPS6KB1 RPS6KB1 RYR3 RYR3 PRKACB PRKACB PLAT PLAT NOS1 NOS1 ADCY2 ADCY2 ACTA2 ACTA2 PRKAB1 PRKAB1 MAPK1 MAPK1 GNB4 GNB4 GNAI2 GNAI2 PIK3C3 PIK3C3 SMAD2 SMAD2 MYL2 MYL2 PPARGC1A PPARGC1A U3K403_FICAL U3K403_FICAL PIK3R6 PIK3R6 GNB1 GNB1 MAP2K1 MAP2K1 CALML4 CALML4 GNG7 GNG7 MEF2C MEF2C MTOR MTOR GNAI1 GNAI1 PLIN1 PLIN1 CAMK4 CAMK4 PLCB1 PLCB1 JAG1 JAG1 PLCB4 PLCB4 AKT3 AKT3 CCN2 CCN2 GNB5 GNB5 HRAS HRAS RPS6KB2 RPS6KB2 CALM1 CALM1 PRKAA2 PRKAA2 PIK3R4 PIK3R4 CALM2 CALM2 SMAD3 SMAD3 GNG12 GNG12 PRKCE PRKCE MYLK4 MYLK4 MRAS MRAS ADCY1 ADCY1 TFAM TFAM TGFBR1 TGFBR1 ADCY5 ADCY5 MYLK MYLK KLF2 KLF2 RYR2 RYR2 GNG4 GNG4 ITPR1 ITPR1 MEF2D MEF2D U3KJG8_FICAL U3KJG8_FICAL CALML3 CALML3 AGTR1 AGTR1 APLNR APLNR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (667 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (326 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (733 aa)
BECN1Uncharacterized protein. (407 aa)
RRAS2RAS related 2. (210 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (398 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
U3JF72_FICALUncharacterized protein. (343 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (292 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (988 aa)
GNA13G protein subunit alpha 13. (291 aa)
GABARAPL2GABA type A receptor associated protein like 2. (124 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CDH1Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (884 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNAQUncharacterized protein. (320 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (583 aa)
NRASNRAS proto-oncogene, GTPase. (156 aa)
GABARAPL1GABA type A receptor associated protein like 1. (121 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (274 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1007 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2692 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (376 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1345 aa)
GNB3G protein subunit beta 3. (340 aa)
LOC101816985Uncharacterized protein. (181 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1147 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
SPP1Uncharacterized protein. (172 aa)
MYL3Uncharacterized protein. (193 aa)
MYLK2Myosin light chain kinase 2. (609 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
RYR3Uncharacterized protein. (4330 aa)
PRKACBUncharacterized protein; Belongs to the protein kinase superfamily. (401 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (558 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1435 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
MAPK1Mitogen-activated protein kinase. (321 aa)
GNB4G protein subunit beta 4. (340 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (882 aa)
SMAD2Mothers against decapentaplegic homolog. (466 aa)
MYL2Myosin light chain 2. (165 aa)
PPARGC1APPARG coactivator 1 alpha. (791 aa)
U3K403_FICALProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (343 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (718 aa)
GNB1G protein subunit beta 1. (340 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (404 aa)
CALML4Calmodulin like 4. (120 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
MEF2CMyocyte enhancer factor 2C. (465 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
GNAI1G protein subunit alpha i1. (354 aa)
PLIN1Perilipin 1. (531 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (324 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1124 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1193 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCN2Cellular communication network factor 2. (347 aa)
GNB5G protein subunit beta 5. (353 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (439 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
PRKAA2Non-specific serine/threonine protein kinase. (523 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1361 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (663 aa)
MYLK4Protein kinase domain-containing protein. (78 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1127 aa)
TFAMTranscription factor A, mitochondrial. (210 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (444 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1216 aa)
MYLKMyosin light chain kinase. (1896 aa)
KLF2Uncharacterized protein. (380 aa)
RYR2Ryanodine receptor 2. (4972 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (79 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2762 aa)
MEF2DMyocyte enhancer factor 2D. (493 aa)
U3KJG8_FICALG protein gamma domain-containing protein. (41 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (332 aa)
Your Current Organism:
Ficedula albicollis
NCBI taxonomy Id: 59894
Other names: F. albicollis, collared flycatcher
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.