STRINGSTRING
RAF1 RAF1 APC APC LPAR1 LPAR1 PDGFD PDGFD CHRM2 CHRM2 SLC9A1 SLC9A1 WASF2 WASF2 RRAS2 RRAS2 MAP2K2 MAP2K2 PAK6 PAK6 ITGB4 ITGB4 LOC101808892 LOC101808892 DOCK1 DOCK1 FGF3 FGF3 FGF4 FGF4 FGF19 FGF19 SOS2 SOS2 GSN GSN FGF6 FGF6 FGF23 FGF23 LOC101810521 LOC101810521 ITGA6 ITGA6 FGFR2 FGFR2 ARPC5L ARPC5L SOS1 SOS1 GNA13 GNA13 IQGAP3 IQGAP3 VAV3 VAV3 PTK2 PTK2 ARPC5 ARPC5 PAK2 PAK2 PDGFC PDGFC INSRR INSRR PIP5K1B PIP5K1B WASF1-2 WASF1-2 FGF18 FGF18 NRAS NRAS PDGFRA PDGFRA ITGA4 ITGA4 ARHGEF4 ARHGEF4 PIKFYVE PIKFYVE ARHGEF6 ARHGEF6 BRAF BRAF KRAS KRAS ARPC2 ARPC2 CYFIP1 CYFIP1 PIK3CB PIK3CB MSN MSN ITGB6 ITGB6 TMSB4X TMSB4X ITGAV ITGAV U3JPP6_FICAL U3JPP6_FICAL EGFR EGFR PFN2 PFN2 MYLK2 MYLK2 SRC SRC CFL2 CFL2 ARHGEF12 ARHGEF12 U3JU34_FICAL U3JU34_FICAL ROCK1 ROCK1 SSH2 SSH2 GIT1 GIT1 F2 F2 U3JUX4_FICAL U3JUX4_FICAL MYL12B MYL12B EGF EGF FGFR1 FGFR1 CRK CRK ROCK2 ROCK2 VCL VCL FGD3 FGD3 ITGB1 ITGB1 CRKL CRKL PIP4K2A PIP4K2A PIK3CD PIK3CD LIMK2 LIMK2 BCAR1 BCAR1 CXCL12 CXCL12 PAK1 PAK1 PXN PXN ITGA8 ITGA8 LOC101817032 LOC101817032 PDGFRB PDGFRB MAPK1 MAPK1 DIAPH3 DIAPH3 ITGB3 ITGB3 FGF2 FGF2 KNG1 KNG1 PIK3CA PIK3CA CYFIP2 CYFIP2 FGF8 FGF8 SPATA13 SPATA13 FGFR4 FGFR4 FGF9 FGF9 RHOA RHOA RDX RDX SSH1 SSH1 FGF1 FGF1 MYL2 MYL2 PPP1CC PPP1CC ARPC3 ARPC3 MYH10 MYH10 U3K403_FICAL U3K403_FICAL MYL10 MYL10 PIK3R3 PIK3R3 ITGA2B ITGA2B ITGB8 ITGB8 PIK3R1 PIK3R1 WASL WASL FGFR3 FGFR3 MAP2K1 MAP2K1 F2R F2R IQGAP2 IQGAP2 SCIN SCIN ITGA11 ITGA11 CDC42 CDC42 ARHGAP35 ARHGAP35 PPP1R12A PPP1R12A ITGA1 ITGA1 ITGA2 ITGA2 FGF16 FGF16 PAK3 PAK3 PAK5 PAK5 FGF10 FGF10 FGF20 FGF20 IQGAP1 IQGAP1 FGF7 FGF7 ENAH ENAH RAC3 RAC3 HRAS HRAS PPP1CA PPP1CA SSH3 SSH3 PDGFB PDGFB BAIAP2 BAIAP2 EZR EZR MYL9 MYL9 PPP1CB PPP1CB FN1 FN1 RAC2 RAC2 GNG12 GNG12 ARPC4 ARPC4 MYLK4 MYLK4 MYH9 MYH9 ITGA9 ITGA9 NCKAP1 NCKAP1 MRAS MRAS PIP4K2B PIP4K2B ITGB2 ITGB2 MYLK MYLK ITGB5 ITGB5 CXCR4 CXCR4 LIMK1 LIMK1 ARPC1B ARPC1B ARPC1A ARPC1A ACTB ACTB PIK3R2 PIK3R2 GNA12 GNA12 FGF22 FGF22 PDGFA PDGFA RAC1 RAC1 MYH11 MYH11 CHRM4 CHRM4 LPAR5 LPAR5 BDKRB2 BDKRB2 BDKRB1 BDKRB1 MOS MOS LPAR4 LPAR4 CHRM3 CHRM3 CHRM5 CHRM5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (667 aa)
APCAPC regulator of WNT signaling pathway. (2927 aa)
LPAR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (369 aa)
PDGFDPlatelet derived growth factor D. (375 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (495 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (733 aa)
WASF2WASP family member 2. (501 aa)
RRAS2RAS related 2. (210 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (398 aa)
PAK6Non-specific serine/threonine protein kinase. (662 aa)
ITGB4Integrin beta. (1733 aa)
LOC101808892Non-specific serine/threonine protein kinase. (543 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1871 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (164 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
GSNGelsolin. (869 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (210 aa)
LOC101810521Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (292 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (962 aa)
FGFR2Fibroblast growth factor receptor. (918 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (80 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1265 aa)
GNA13G protein subunit alpha 13. (291 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (746 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (104 aa)
PAK2Non-specific serine/threonine protein kinase. (521 aa)
PDGFCPlatelet derived growth factor C. (345 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (545 aa)
WASF1-2WH2 domain-containing protein. (239 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
NRASNRAS proto-oncogene, GTPase. (156 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1087 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (928 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (625 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2117 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (773 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (715 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (302 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
MSNMoesin. (569 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (791 aa)
TMSB4XThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (998 aa)
U3JPP6_FICALVWFA domain-containing protein. (535 aa)
EGFRReceptor protein-tyrosine kinase. (1164 aa)
PFN2Profilin; Belongs to the profilin family. (96 aa)
MYLK2Myosin light chain kinase 2. (609 aa)
SRCTyrosine-protein kinase. (539 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (149 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1602 aa)
U3JU34_FICALProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (286 aa)
ROCK1Uncharacterized protein. (1150 aa)
SSH2Slingshot protein phosphatase 2. (1347 aa)
GIT1GIT ArfGAP 1. (800 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (608 aa)
U3JUX4_FICALUncharacterized protein. (193 aa)
MYL12BUncharacterized protein. (172 aa)
EGFEpidermal growth factor. (1255 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
CRKCRK proto-oncogene, adaptor protein. (281 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1411 aa)
VCLVinculin. (1168 aa)
FGD3FYVE, RhoGEF and PH domain containing 3. (689 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (651 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (370 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
LIMK2LIM domain kinase 2. (642 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (923 aa)
CXCL12C-X-C motif chemokine ligand 12. (131 aa)
PAK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (499 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (572 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1044 aa)
LOC101817032Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
PDGFRBPlatelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1093 aa)
MAPK1Mitogen-activated protein kinase. (321 aa)
DIAPH3Diaphanous related formin 3. (1048 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (780 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (118 aa)
KNG1Uncharacterized protein; Belongs to the cystatin family. (224 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1252 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
SPATA13Uncharacterized protein. (1385 aa)
FGFR4Fibroblast growth factor receptor. (803 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RHOARas homolog family member A. (172 aa)
RDXRadixin. (594 aa)
SSH1Slingshot protein phosphatase 1. (1056 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MYL2Myosin light chain 2. (165 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (309 aa)
ARPC3Actin related protein 2/3 complex subunit 3. (328 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1976 aa)
U3K403_FICALProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (343 aa)
MYL10Uncharacterized protein. (165 aa)
PIK3R3Uncharacterized protein. (753 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1020 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
WASLWASP like actin nucleation promoting factor. (506 aa)
FGFR3Fibroblast growth factor receptor 3. (653 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (404 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (421 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1659 aa)
SCINScinderin. (777 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1190 aa)
CDC42Cell division cycle 42. (191 aa)
ARHGAP35Rho GTPase activating protein 35. (1063 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1033 aa)
ITGA1Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (653 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1317 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (169 aa)
PAK3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (290 aa)
PAK5Non-specific serine/threonine protein kinase. (723 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (149 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1656 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (177 aa)
ENAHENAH actin regulator. (785 aa)
RAC3Rac family small GTPase 3. (180 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (345 aa)
SSH3Slingshot protein phosphatase 3. (615 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (251 aa)
BAIAP2BAI1 associated protein 2. (502 aa)
EZREzrin. (648 aa)
MYL9Myosin light chain 9. (180 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
FN1Fibronectin 1. (2307 aa)
RAC2Rac family small GTPase 2. (192 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (167 aa)
MYLK4Protein kinase domain-containing protein. (78 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1961 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1039 aa)
NCKAP1NCK associated protein 1. (1028 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (366 aa)
ITGB2Integrin beta. (776 aa)
MYLKMyosin light chain kinase. (1896 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (807 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (366 aa)
LIMK1LIM domain kinase 1. (624 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (371 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ACTBActin beta. (378 aa)
PIK3R2Uncharacterized protein. (727 aa)
GNA12G protein subunit alpha 12. (340 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (101 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
RAC1Rac family small GTPase 1. (192 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1983 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (490 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (376 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (380 aa)
BDKRB1Bradykinin receptor B1. (361 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (349 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (348 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (600 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (528 aa)
Your Current Organism:
Ficedula albicollis
NCBI taxonomy Id: 59894
Other names: F. albicollis, collared flycatcher
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