(70 nodes) GnRH signaling pathway network (Ficedula albicollis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (667 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1069 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (973 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (398 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1265 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (684 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1241 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1711 aa)
	CGA	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (126 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2159 aa)
	GNAQ	Uncharacterized protein. (320 aa)
	PLA2G4A	Phospholipase A2. (753 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (583 aa)
	NRAS	NRAS proto-oncogene, GTPase. (156 aa)
	PRKCD	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (702 aa)
	MAPK13	Mitogen-activated protein kinase. (367 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
	KRAS	KRAS proto-oncogene, GTPase. (188 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2664 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2692 aa)
	MAP3K2	Mitogen-activated protein kinase kinase kinase 2. (624 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1345 aa)
	MAP3K3	Mitogen-activated protein kinase kinase kinase 3. (649 aa)
	EGFR	Receptor protein-tyrosine kinase. (1164 aa)
	SRC	Tyrosine-protein kinase. (539 aa)
	MAPK10	Mitogen-activated protein kinase. (426 aa)
	PLA2G4F	Phospholipase A2. (852 aa)
	U3JTQ6_FICAL	PLA2c domain-containing protein. (581 aa)
	LOC101815404	Phospholipase A2. (822 aa)
	LOC101822056	Phospholipase A2. (804 aa)
	PRKACB	Uncharacterized protein; Belongs to the protein kinase superfamily. (401 aa)
	CAMK2G	Calcium/calmodulin dependent protein kinase II gamma. (608 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
	MAPK8	Mitogen-activated protein kinase. (384 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	MMP2	Matrix metallopeptidase 2. (661 aa)
	MAPK1	Mitogen-activated protein kinase. (321 aa)
	CAMK2A	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (489 aa)
	PLD1	Phospholipase. (1075 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2160 aa)
	HBEGF	Heparin binding EGF like growth factor. (206 aa)
	MAPK11	Mitogen-activated protein kinase. (333 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (404 aa)
	U3K692_FICAL	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	CALML4	Calmodulin like 4. (120 aa)
	CDC42	Cell division cycle 42. (191 aa)
	GNAS	GNAS complex locus. (320 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1124 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1344 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
	GNRH1	Gonadotropin releasing hormone 1. (89 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (396 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	MAP3K4	Mitogen-activated protein kinase kinase kinase 4. (1563 aa)
	FSHB	Follicle stimulating hormone subunit beta. (134 aa)
	CALM1	Uncharacterized protein; Belongs to the calmodulin family. (113 aa)
	ATF4	Activating transcription factor 4. (354 aa)
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (149 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1127 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1216 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2762 aa)
	MAP2K3	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (348 aa)
	GNA11	G protein subunit alpha 11. (315 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (314 aa)

Your Current Organism:

Ficedula albicollis

NCBI taxonomy Id: 59894
Other names: F. albicollis, collared flycatcher

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSFALP00000013795	ENSFALP00000007485	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.431
ADCY1	ADCY5	ENSFALP00000013795	ENSFALP00000013939	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.432
ADCY1	ADCY6	ENSFALP00000013795	ENSFALP00000000131	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.429
ADCY1	ADCY7	ENSFALP00000013795	ENSFALP00000000090	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.431
ADCY1	ADCY8	ENSFALP00000013795	ENSFALP00000002681	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.956
ADCY1	ADCY9	ENSFALP00000013795	ENSFALP00000004505	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.661
ADCY1	CALM1	ENSFALP00000013795	ENSFALP00000012791	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.934
ADCY1	CALM2	ENSFALP00000013795	ENSFALP00000013389	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 2; Belongs to the calmodulin family.	0.934
ADCY1	CALML3	ENSFALP00000013795	ENSFALP00000015550	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.934
ADCY1	CALML4	ENSFALP00000013795	ENSFALP00000010578	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.931
ADCY1	GNAS	ENSFALP00000013795	ENSFALP00000011190	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.964
ADCY1	PRKACB	ENSFALP00000013795	ENSFALP00000006254	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.932
ADCY2	ADCY1	ENSFALP00000007485	ENSFALP00000013795	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.431
ADCY2	ADCY5	ENSFALP00000007485	ENSFALP00000013939	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.640
ADCY2	ADCY6	ENSFALP00000007485	ENSFALP00000000131	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.646
ADCY2	ADCY8	ENSFALP00000007485	ENSFALP00000002681	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.431
ADCY2	ADCY9	ENSFALP00000007485	ENSFALP00000004505	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.551
ADCY2	GNAS	ENSFALP00000007485	ENSFALP00000011190	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.968
ADCY2	PRKACB	ENSFALP00000007485	ENSFALP00000006254	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.922
ADCY5	ADCY1	ENSFALP00000013939	ENSFALP00000013795	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.432