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| | cbiD | CbiD protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (372 aa) |
| | thiL | Putative thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (328 aa) |
| | purF | Glutamine amidotransferase class-II:Phosphoribosyl transferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (486 aa) |
| | dnaN | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (385 aa) |
| | argD | N-acetylornithine aminotransferase; Alternative locus ID: PMED4_14681; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (417 aa) |
| | putative | UDP-N-glucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (457 aa) |
| | spoU | tRNA/rRNA methyltransferase (SpoU); Alternative locus ID: PMED4_14651. (246 aa) |
| | lnt | Possible apolipoprotein n-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (496 aa) |
| | mnmA | tRNA methyl transferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (390 aa) |
| | trmD | Putative bifuntional enzyme: tRNA methyltransferase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP); Belongs to the RNA methyltransferase TrmD family. (407 aa) |
| | thiE | Thiamine monophosphate synthase (TMP); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). (351 aa) |
| | ribF | Putative riboflavin kinase/FAD synthase; Citation: Gupta et al. (1999) FEMS Microbiol Lett 179:501-506; Alternative locus ID: PMED4_14391; Belongs to the ribF family. (307 aa) |
| | nadK2 | Predicted sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (302 aa) |
| | cobL | Putative precorrin-6y methylase; Citation: Blanche et al. (1992) J. Bacteriol. 174:1050-1052; Alternative locus ID: PMED4_14341. (426 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (308 aa) |
| | PMM1259 | Pyridoxal-phosphate-dependent aminotransferase; Alternative locus ID: PMED4_14251; Belongs to the DegT/DnrJ/EryC1 family. (388 aa) |
| | PMM1258 | Pyridoxal-phosphate-dependent aminotransferase; Alternative locus ID: PMED4_14241; Belongs to the DegT/DnrJ/EryC1 family. (382 aa) |
| | PMM1256 | Putative glycosyl transferase, family 2; Alternative locus ID: PMED4_14221. (292 aa) |
| | PMM1254 | Putative glycosyl transferase, family 2; Alternative locus ID: PMED4_14201. (324 aa) |
| | PMM1253 | Possible methyltransferase; Alternative locus ID: PMED4_14191. (213 aa) |
| | PMM1252 | Possible acetyltransferase; Alternative locus ID: PMED4_14181. (150 aa) |
| | PMM1251 | Carbamoyltransferase; Alternative locus ID: PMED4_14171. (617 aa) |
| | PMM1246 | Carbamoyltransferase; Alternative locus ID: PMED4_14111. (610 aa) |
| | PMM1243 | Possible methyltransferase; Alternative locus ID: PMED4_14081. (281 aa) |
| | PMM1241 | Hypothetical protein; Alternative locus ID: PMED4_14061. (282 aa) |
| | PMM1240 | Methyltransferase; Alternative locus ID: PMED4_14051. (223 aa) |
| | PMM1232 | Methyltransferase; Alternative locus ID: PMED4_13971. (418 aa) |
| | PMM1227 | Putative UDP-N-acetylglucosamine-1-phosphate transferase; Alternative locus ID: PMED4_13921. (325 aa) |
| | PMM1223 | Putative glycosyl transferase, group 1; Alternative locus ID: PMED4_13881. (382 aa) |
| | PMM1222 | Possible glycosyl transferase; Alternative locus ID: PMED4_13871. (327 aa) |
| | PMM1221 | Glycosyl transferase, group 1; Alternative locus ID: PMED4_13861. (366 aa) |
| | PMM1220 | Putative glycosyl transferase; Alternative locus ID: PMED4_13851. (319 aa) |
| | rfaE | Putative ADP-heptose synthase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (500 aa) |
| | PMM1216 | Putative sugar-phosphate nucleotidyl transferase; Alternative locus ID: PMED4_13811. (239 aa) |
| | PMM1213 | Glycosyl transferases group 1; Alternative locus ID: PMED4_13781. (386 aa) |
| | PMM1206 | Hypothetical protein; Alternative locus ID: PMED4_13711. (463 aa) |
| | ddhA, | Glucose-1-phosphate cytidylyltransferase; Alternative locus ID: PMED4_13691. (255 aa) |
| | PMM1200 | Glycosyl transferase, family 2; Alternative locus ID: PMED4_13651. (317 aa) |
| | PMM1199 | Conserved hypothetical protein; Alternative locus ID: PMED4_13641. (370 aa) |
| | PMM1198 | Hypothetical protein; Alternative locus ID: PMED4_13631. (457 aa) |
| | manC | GDP-mannose pyrophosphorylase; Alternative locus ID: PMED4_13611; Belongs to the mannose-6-phosphate isomerase type 2 family. (485 aa) |
| | rsmI | Putative tetrapyrrole methylase family protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (287 aa) |
| | pnp | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (721 aa) |
| | PMM1178 | Glycosyl transferases group 1; Alternative locus ID: PMED4_13431. (364 aa) |
| | PMM1177 | Conserved hypothetical protein; Alternative locus ID: PMED4_13421. (601 aa) |
| | F4P13.20 | Conserved hypothetical protein; Alternative locus ID: PMED4_13331. (214 aa) |
| | ilvH-2 | Acetolactate synthase small subunit; Alternative locus ID: PMED4_13141. (174 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (976 aa) |
| | PMM1132 | Conserved hypothetical protein; Alternative locus ID: PMED4_12841. (567 aa) |
| | PMM1126 | Domain of unknown function DUF33; Alternative locus ID: PMED4_12741. (671 aa) |
| | apt | Phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (171 aa) |
| | PMM1120 | Sulfotransferase:TPR repeat; Alternative locus ID: PMED4_12661. (613 aa) |
| | gidA | NAD binding site:Glucose inhibited division protein A family; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. (470 aa) |
| | PMM1108 | Phospholipid and glycerol acyltransferase (from 'motifs_6.msf'); Alternative locus ID: PMED4_12541. (225 aa) |
| | pdxJ | Pyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (238 aa) |
| | lipA,lip | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (299 aa) |
| | BioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (335 aa) |
| | uppS | Undecaprenyl pyrophosphate synthetase (UPPS); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (272 aa) |
| | miaB | Conserved hypothetical protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (464 aa) |
| | PMM1841 | Type III restriction system endonuclease; Alternative locus ID: PMED4_04241. (496 aa) |
| | thrC | Threonine synthase: Pyridoxal-5'-phosphate-dependent enzymes, beta family; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (367 aa) |
| | PMM1714 | Possible protein kinase:ABC1 family; Alternative locus ID: PMED4_19261. (618 aa) |
| | sps | Sucrose phosphate synthase; Alternative locus ID: PMED4_19231. (468 aa) |
| | mraY | Putative phospho-N-acetylmuramoyl-pentapeptide-transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (359 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa) |
| | aroF | DAHP synthetase class I; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (355 aa) |
| | ppk | Putative Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (695 aa) |
| | cobA | Putative uroporphyrin-III C-methyltransferase; 2 S-ADENOSYL-L-METHIONINE + UROPORPHYRIN III = 2 S-ADENOSYL-L-HOMOCYSTEINE + SIROHYDROCHLORIN; Citation: Crouzet et al. (199) J. Bacteriol. 172:5968-5979; Blanche et al. (1989) J. Bacteriol. 171:4222-4231 (1989); Alternative locus ID: PMED4_19051; Belongs to the precorrin methyltransferase family. (261 aa) |
| | PMM1693 | Aminotransferases class-IV; Hypothetical aminotransferase; Alternative locus ID: PMED4_19041. (275 aa) |
| | gcvT | Putative Glycine cleavage T-protein (aminomethyl transferase); The glycine cleavage system catalyzes the degradation of glycine. (370 aa) |
| | speE | Putative spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (283 aa) |
| | sqdX | SqdX; Alternative locus ID: PMED4_18761. (377 aa) |
| | thiG | Thiamin biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (265 aa) |
| | PMM1659 | Glycosyl transferase, family 2; Alternative locus ID: PMED4_18691. (433 aa) |
| | dnaX | DNA polymerase, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (579 aa) |
| | lysC | Aspartate kinase; Putative assignment; alpha and beta subunits, and additional region with similarity to beta subunit (BY SIMILARITY); Alternative locus ID: PMED4_18581. (586 aa) |
| | PMM1647 | Conserved hypothetical protein; Alternative locus ID: PMED4_18571. (333 aa) |
| | ribH | Putative 6,7-dimethyl-8-ribityllumazine synthase or riboflavin synthase beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (158 aa) |
| | PMM1640 | Putative acetyltransferase, GNAT family; Alternative locus ID: PMED4_18501. (151 aa) |
| | cysE | Serine acetyltransferase; Alternative locus ID: PMED4_18481. (244 aa) |
| | miaA,trpX | tRNA delta-2-isopentenylpyrophosphate (IPP) transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (299 aa) |
| | PMM1627 | Putative carbohydrate kinase; Alternative locus ID: PMED4_18371. (332 aa) |
| | tktA, | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (668 aa) |
| | fabF | 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa) |
| | glmS | Glutamine--fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (631 aa) |
| | PMM1601 | Phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (848 aa) |
| | PMM1597 | Conserved hypothetical protein; Alternative locus ID: PMED4_18071. (452 aa) |
| | panC, | Putative bifunctional enzyme; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. (510 aa) |
| | rodA | Peptidoglycan glycosyltransferase RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (423 aa) |
| | PMM1579 | Conserved hypothetical protein; Alternative locus ID: PMED4_17891. (455 aa) |
| | PMM1571 | Conserved hypothetical protein; Alternative locus ID: PMED4_17811. (274 aa) |
| | PMM1570 | ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Alternative locus ID: PMED4_17801. (386 aa) |
| | moeB | Molybdopterin biosynthesis protein; BELONGS TO THE HESA/MOEB/THIF FAMILY; Citation: Nohno et al (1988) J. Bacteriol. 170:4097-4102; Alternative locus ID: PMED4_17791. (382 aa) |
| | PMM1567 | Conserved hypothetical protein; Alternative locus ID: PMED4_17771; Belongs to the fructosamine kinase family. (292 aa) |
| | rpl2, | 50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (287 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (184 aa) |
| | rpoA | Bacterial RNA polymerase, alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (312 aa) |
| | cbiG/cobJ | Bifunctional cbiH protien and PRECORRIN-3B C17-METHYLTRANSFERASE; Citation: Debussche et al. (1993) J. Bacteriol. 175:7430-7440; Roth et al. (1993) J. Bacteriol. 175:3303-3316; Alternative locus ID: PMED4_17351. (606 aa) |
| | PMM1522 | Glycosyl transferase, family 2; Alternative locus ID: PMED4_17321. (320 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (297 aa) |
| | PMM1505 | SAM (and some other nucleotide) binding motif; Alternative locus ID: PMED4_17151; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family. (311 aa) |
| | dapL | Putative aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (408 aa) |
| | PMM1497 | Glycosyl transferase, family 2; Alternative locus ID: PMED4_17071. (363 aa) |
| | PMM1496 | Dolichyl-phosphate-mannose-protein mannosyltransferase; Alternative locus ID: PMED4_17061. (515 aa) |
| | rpoB | RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1097 aa) |
| | rpoC1 | RNA polymerase gamma subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (634 aa) |
| | rpoC2 | RNA polymerase beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily. (1366 aa) |
| | rlmN | Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (348 aa) |
| | gidB | Putative glucose inhibited division protein B; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (239 aa) |
| | BioA | Putative diaminopelargonic acid synthase; Citation: Otsuka et al. (1988) J. Biol. Chem. 263:19577-19585; Kack et al. (1999) J. Mol. Biol. 291:857-876; Alternative locus ID: PMED4_16811; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (433 aa) |
| | bioF | Putative 8-amino-7-oxononanoate synthase; Citation: Otsuka et al. (1988) J. Biol. Chem. 263:19577-19585; Alexeev et al. (1998) J. Mol. Biol. 284:401-419; Alternative locus ID: PMED4_16771. (381 aa) |
| | PMM1464 | FtsJ cell division protein:S4 domain:Hemolysin A; Alternative locus ID: PMED4_16731. (270 aa) |
| | PMM1445 | Putative nicotinate-nucleotide adenylyltransferase; Alternative locus ID: PMED4_16541; Belongs to the NadD family. (193 aa) |
| | pyrR | Phosphoribosyl transferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (180 aa) |
| | rpoZ | Putative DNA-directed RNA polymerase (omega chain); Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (78 aa) |
| | PMM1369 | GAF domain; Alternative locus ID: PMED4_15401. (250 aa) |
| | prmA | Putative methyltransferase for Ribosomal protein L11; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (300 aa) |
| | kaiC | Possible circadian clock protein KaiC; Core component of the KaiBC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiBC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction; Belongs to the KaiC family. (509 aa) |
| | nblS | Two-component sensor histidine kinase; Alternative locus ID: PMED4_15091. (689 aa) |
| | fabZ | Putative (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (152 aa) |
| | lpxA | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (280 aa) |
| | lpxB | Lipid-A-disaccharide synthetase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (392 aa) |
| | plsY | Conserved hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (198 aa) |
| | glgX | Putative isoamylase; Alternative locus ID: PMED4_14901; Belongs to the glycosyl hydrolase 13 family. (677 aa) |
| | panB | Putative Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (257 aa) |
| | dacA | Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (296 aa) |
| | PMM1089 | Putative ribosomal-protein-alanine acetyltransferase; Alternative locus ID: PMED4_12351. (144 aa) |
| | PMM1085 | Phosphatidate cytidylyltransferase; Alternative locus ID: PMED4_12311; Belongs to the CDS family. (285 aa) |
| | PMM1083 | Possible kinase; Alternative locus ID: PMED4_12291. (552 aa) |
| | malQ | Putative 4-alpha-glucanotransferase; Alternative locus ID: PMED4_12271. (506 aa) |
| | kprS | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (331 aa) |
| | sasA | Two-component sensor histidine kinase; May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs. (372 aa) |
| | crtE | Polyprenyl synthetase; Alternative locus ID: PMED4_12161; Belongs to the FPP/GGPP synthase family. (300 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (546 aa) |
| | PMM1065 | Conserved hypothetical protein; Alternative locus ID: PMED4_12111; Belongs to the glycosyl hydrolase 57 family. (527 aa) |
| | hisH | Glutamine amidotransferase class-I; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (205 aa) |
| | PMM1059 | Conserved hypothetical protein; Has F-G-G motif of methylases; Alternative locus ID: PMED4_12051. (195 aa) |
| | trmJ | Probable tRNA/rRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (247 aa) |
| | rbsK | Possible pfkB family carbohydrate kinase; Alternative locus ID: PMED4_11901. (325 aa) |
| | purT | GAR transformylase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (390 aa) |
| | PMM0994 | GCN5-related N-acetyltransferase; Alternative locus ID: PMED4_11151. (153 aa) |
| | PMM0989 | ATP/GTP-binding site motif A (P-loop); Alternative locus ID: PMED4_11091. (201 aa) |
| | PMM0985 | Putative PURINE PHOSPHORIBOSYLTRANSFERASE related protein; Alternative locus ID: PMED4_11051. (131 aa) |
| | PMM0961 | Glycoside hydrolase family 13; Alternative locus ID: PMED4_10731. (585 aa) |
| | trpD/G | Putative Anthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (343 aa) |
| | PMM0948 | tRNA/rRNA methyltransferase; Alternative locus ID: PMED4_10591; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (428 aa) |
| | dnaE | DNA polymerase III, alpha subunit; Alternative locus ID: PMED4_10561. (1165 aa) |
| | dnaG | CHC2 zinc finger:Toprim domain; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (678 aa) |
| | PMM0938 | Possible Serine hydroxymethyltransferase; Alternative locus ID: PMED4_10491. (151 aa) |
| | rlmH | Conserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (137 aa) |
| | rsmA | Putative rRNA (adenine-N6,N6)-dimethyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (277 aa) |
| | ispE | Putative 4-diphosphocytidyl-2C-methyl-D-erythritol kinase (CMK); Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (312 aa) |
| | PMM0925 | Conserved hypothetical protein; Alternative locus ID: PMED4_10361. (350 aa) |
| | PMM0921 | SAM (and some other nucleotide) binding motif:Generic methyl-transferase; Alternative locus ID: PMED4_10321. (351 aa) |
| | spt, | Class-V aminotransferase; Alternative locus ID: PMED4_10301. (394 aa) |
| | pykF | Pyruvate kinase; Alternative locus ID: PMED4_10231; Belongs to the pyruvate kinase family. (596 aa) |
| | Dxs | 1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (637 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (218 aa) |
| | nifS | Possible cysteine desulfurase (class-V aminotransferase family); Alternative locus ID: PMED4_09981. (390 aa) |
| | coaD | Putative pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | ilvE | Putative Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (304 aa) |
| | metH | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1186 aa) |
| | PMM0874 | Possible ATP adenylyltransferase; Alternative locus ID: PMED4_09851. (276 aa) |
| | cobU/cobP | Putative cobinamide kinase; Citation: O'Toole and Excalante-Semerena (1995) J. Biol. Chem. 270:23560-23569; Thomas et al. (2000) J. Biol. Chem. 275:27576-27586; Alternative locus ID: PMED4_09731. (182 aa) |
| | PMM0862 | Putative tRNA/rRNA methyltransferase (SpoU family); Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. (160 aa) |
| | fmt | Putative Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (328 aa) |
| | PMM0838 | Possible Nucleoside diphosphate kinase; Alternative locus ID: PMED4_09321. (122 aa) |
| | folP | Putative dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (280 aa) |
| | pgsA | CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase; Alternative locus ID: PMED4_08841; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (180 aa) |
| | proB | Putative glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (360 aa) |
| | lpxD | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (344 aa) |
| | prk, | Phosphoribulokinase; Alternative locus ID: PMED4_08711. (299 aa) |
| | accD | acetyl-CoA carboxylase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (292 aa) |
| | PMM0776 | Putative uracil phosphoribosyltransferase; Alternative locus ID: PMED4_08611. (205 aa) |
| | glgC | ADP-glucose pyrophosphorylase; Alternative locus ID: PMED4_08541; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (431 aa) |
| | PMM0752 | Glycosyl transferase, family 2; Alternative locus ID: PMED4_08371. (305 aa) |
| | phoR | Two-component sensor histidine kinase, phosphate sensing; Alternative locus ID: PMED4_07801. (382 aa) |
| | PMM0695 | Glutamine amidotransferase class-I; Alternative locus ID: PMED4_07641. (242 aa) |
| | PMM0681 | Conserved hypothetical protein; Alternative locus ID: PMED4_07371. (396 aa) |
| | nadA | Quinolinate synthetase A protein; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa) |
| | PMM0675 | Uracil-DNA glycosylase; Alternative locus ID: PMED4_07311. (167 aa) |
| | aspC | Aminotransferases class-I; Possible role in phosphonate metabolism; Alternative locus ID: PMED4_07301. (393 aa) |
| | PMM0668 | Conserved hypothetical protein 46; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (257 aa) |
| | metA | Putative homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (296 aa) |
| | cysD-2 | Putative O-Acetyl homoserine sulfhydrylase; Alternative locus ID: PMED4_06921. (442 aa) |
| | GSTTLp28 | Glutathione S-transferase N terminus; Alternative locus ID: PMED4_06801. (219 aa) |
| | dnaQ | Possible DNA polymerase III, epsilon subunit; Alternative locus ID: PMED4_06701. (270 aa) |
| | sds | Polyprenyl synthetase; Alternative locus ID: PMED4_06671; Belongs to the FPP/GGPP synthase family. (323 aa) |
| | aroA | EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (438 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (449 aa) |
| | glgA | Putative ADPglucose--glucosyltransferase (GlgA); Synthesizes alpha-1,4-glucan chains using ADP-glucose. (483 aa) |
| | menD | Menaquinone biosynthesis protein; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). (588 aa) |
| | PMM0596 | Putative glucokinase; Alternative locus ID: PMED4_06451; Belongs to the bacterial glucokinase family. (345 aa) |
| | thrB | Homoserine kinase:GHMP kinases putative ATP-binding domain; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (315 aa) |
| | glgB | 1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (754 aa) |
| | PMM0566 | Conserved hypothetical protein; Alternative locus ID: PMED4_06151. (412 aa) |
| | PMM0562 | Possible acetyltransferase; Alternative locus ID: PMED4_06111. (176 aa) |
| | hisG | Possible ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (215 aa) |
| | accA | acetyl-CoA carboxylase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (335 aa) |
| | PMM0528 | DUF152; Alternative locus ID: PMED4_05771; Belongs to the multicopper oxidase YfiH/RL5 family. (260 aa) |
| | ilvH | Acetolactate synthase large subunit; Alternative locus ID: PMED4_05751. (587 aa) |
| | cobO | Possible cob(I)alamin adenosyltransferase; Citation: Lundrigan and Kadner (1989) J. Bacteriol. 171:154-161; Fonseca and Escalente-Semerena (2001) J. Biol. Chem. 276:32101-32108; Alternative locus ID: PMED4_05721. (231 aa) |
| | pyrH,smbA | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (234 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (333 aa) |
| | PMM0510 | Possible Reverse transcriptase (RNA-dependent; Alternative locus ID: PMED4_05591. (84 aa) |
| | PMM0505 | Possible carbohydrate kinase; Alternative locus ID: PMED4_05541; Belongs to the carbohydrate kinase PfkB family. (338 aa) |
| | argB | Aspartokinase superfamily:Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (284 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (316 aa) |
| | hemL, | Glutamate-1-semialdehyde 2,1-aminomutase; Alternative locus ID: PMED4_05321; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (433 aa) |
| | PMM0480 | Conserved hypothetical protein; Alternative locus ID: PMED4_05281. (170 aa) |
| | tsaD | Probable o-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (356 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (184 aa) |
| | yvoC, | Putative prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (297 aa) |
| | cobM | PUTATIVE PRECORRIN-4 C11-METHYLTRANSFERASE; Citation: Crouzet et al. (1990) J. Bacteriol. 172:5980-5990; Debussche et al. (1993) J. Bacteriol. 175:7430-7440; Alternative locus ID: PMED4_05071. (251 aa) |
| | ubiA | Probable 4-hydroxybenzoate-octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of plastoquinone-9 (PQ-9) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 4-hydroxy-3-solanesylbenzoate. Belongs to the UbiA prenyltransferase family. (295 aa) |
| | ispD | Putative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (223 aa) |
| | fabG | 3-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa) |
| | ctaB | Putative protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (332 aa) |
| | ribE | Putative Riboflavin synthase alpha chain; Citation: Eberhardt et al. (1996) Eur. J. Biochem. 242:712-719; Alternative locus ID: PMED4_04891. (219 aa) |
| | PMM0439 | Conserved hypothetical protein; Alternative locus ID: PMED4_04861; Belongs to the UPF0284 family. (385 aa) |
| | menG | Conserved hypothetical protein; Methyltransferase required for the conversion of 2-phytyl- 1,4-beta-naphthoquinol to phylloquinol. (233 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (255 aa) |
| | chlG | Chlorophyll synthase 33 kD subunit; Alternative locus ID: PMED4_04751. (315 aa) |
| | PMM0427 | Putative penicillin binding protein; Alternative locus ID: PMED4_04741. (587 aa) |
| | PMM0426 | Sun protein (Fmu protein); Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (437 aa) |
| | trmH | tRNA/rRNA methyltransferase (SpoU); Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (223 aa) |
| | metB | Putative Cystathionine gamma-synthase; Alternative locus ID: PMED4_04521. (387 aa) |
| | cysK1 | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_04501; Belongs to the cysteine synthase/cystathionine beta- synthase family. (328 aa) |
| | queA | Queuosine biosynthesis protein; Synthesizes oQ from preQ1 in a single S-adenosylmethionine- requiring step. The ribosyl moiety of AdoMet is transferred and isomerized to the epoxycyclopentane residue of oQ (By similarity). Belongs to the QueA family. (374 aa) |
| | pdhC | Dihydrolipoamide acetyltransferase component (E2) of pyruvate de; Alternative locus ID: PMED4_04481. (455 aa) |
| | lipB | Putative lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (214 aa) |
| | PMM0397 | Possible Glycosyl transferase, group 1; Alternative locus ID: PMED4_04381. (388 aa) |
| | cobI/cbiL | PRECORRIN-2 C20-METHYLTRANSFERASE; Cobalamin biosynthesis; Citation: Crouzet et al. (1990) J. Bacteriol. 172:5980-5990; Roth et al. (1993) J. Bacteriol. 175:3303-3316; Alternative locus ID: PMED4_04301; Belongs to the precorrin methyltransferase family. (251 aa) |
| | PMM0386 | Possible uncharacterized DNA methylase; Alternative locus ID: PMED4_04251. (214 aa) |
| | PMM0382 | Possible Ribosomal RNA adenine dimethylase; Alternative locus ID: PMED4_04201. (168 aa) |
| | PMM0361 | Possible Phosphoenolpyruvate carboxykinase; Alternative locus ID: PMED4_03861. (125 aa) |
| | thiD | Phosphomethylpyrimidine kinase; Citation: Peterson and Downs (1997) J. Bacteriol. 179:4894-4900; Alternative locus ID: PMED4_03821. (262 aa) |
| | PMM0354 | Possible Glycosyl transferase; Alternative locus ID: PMED4_03731. (209 aa) |
| | PMM0353 | Glycosyl transferase family 11; Alternative locus ID: PMED4_03721. (277 aa) |
| | rimI | GCN5-related N-acetyltransferase; Alternative locus ID: PMED4_03401. (295 aa) |
| | hemK | Putative protein methyltransferase; Alternative locus ID: PMED4_03241. (289 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (413 aa) |
| | PMM0310 | Carbohydrate kinase, FGGY family; Alternative locus ID: PMED4_03161. (409 aa) |
| | PMM0303 | tRNA nucleotidyltransferase/poly(A) polymerase; Alternative locus ID: PMED4_03081; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (415 aa) |
| | selD | Selenide,water dikinase; Alternative locus ID: PMED4_03071. (730 aa) |
| | mtnP | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (307 aa) |
| | PMM0291 | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (440 aa) |
| | folK | Possible 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Citation: Talarico et al. (1992) J. Bacteriol. 174:5971-5977; Alternative locus ID: PMED4_02921. (187 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase; Alternative locus ID: PMED4_02871. (260 aa) |
| | PMM0278 | Phosphotransferase superclass; Alternative locus ID: PMED4_02831. (486 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (186 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (372 aa) |
| | CobS | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (246 aa) |
| | PMM0269 | Two-component sensor histidine kinase; Alternative locus ID: PMED4_02741. (378 aa) |
| | purH | AICARFT/IMPCHase bienzyme:Methylglyoxal synthase-like domain; Alternative locus ID: PMED4_02711. (517 aa) |
| | glyA | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa) |
| | PMM0245 | cob(I)alamin adenosyltransferase; Alternative locus ID: PMED4_02501. (191 aa) |
| | PMM0243 | Possible Thy1 protein homolog; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (212 aa) |
| | trmB | Conserved hypothetical protein; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (209 aa) |
| | pyrB | Aspartate carbamoyltransferase; Putative assignment; Alternative locus ID: PMED4_02381; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (338 aa) |
| | cysD | ATP-sulfurylase; Alternative locus ID: PMED4_02321. (391 aa) |
| | PMM0221 | Conserved hypothetical protein; Alternative locus ID: PMED4_02256. (315 aa) |
| | PMM0209 | Possible kinase; Alternative locus ID: PMED4_02151. (555 aa) |
| | hisC/cobC | Aminotransferases class-I; Citation: Crouzet et al. (1990) J. Bacteriol. 172:5968-5979; Alternative locus ID: PMED4_02041. (374 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (364 aa) |
| | pgk, | Phosphoglycerate kinase; Alternative locus ID: PMED4_02011; Belongs to the phosphoglycerate kinase family. (402 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase:Quinolinate phosphoriobsyl transferase; Alternative locus ID: PMED4_01941; Belongs to the NadC/ModD family. (288 aa) |
| | hisC | Aminotransferases class-I; Conserved hypothetical assignment; Alternative locus ID: PMED4_01921. (369 aa) |
| | dgkA | Prokaryotic diacylglycerol kinase; Alternative locus ID: PMED4_01891. (138 aa) |
| | menA | 1,4-dihydroxy-2-naphthoate (DHNA) octaprenyltransferase; Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone; Belongs to the MenA family. Type 2 subfamily. (305 aa) |
| | rsmH | Conserved hypothetical protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (300 aa) |
| | PMM0170 | NifS-like aminotransferase class-V; Alternative locus ID: PMED4_01761. (382 aa) |
| | chlM | Mg-protoporphyrin IX methyltransferase; Alternative locus ID: PMED4_01741. (233 aa) |
| | cysC | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (208 aa) |
| | gltA | Citrate synthase; Alternative locus ID: PMED4_01671; Belongs to the citrate synthase family. (381 aa) |
| | nadK1 | Predicted inorganic polyphosphate / ATP-NAD+ kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (299 aa) |
| | cugP | Putative sugar-phosphate nucleotidyl transferase; Catalyzes the formation of UDP-glucose, from UTP and glucose 1-phosphate. (392 aa) |
| | crtB,pys | Squalene and phytoene synthases; Alternative locus ID: PMED4_01491. (302 aa) |
| | PMM0141 | Poly A polymerase family; Citation: Kushner (2002) J. Bacteriol. 184:4658-4665; Alternative locus ID: PMED4_01471; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (415 aa) |
| | plsC | Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase; Alternative locus ID: PMED4_01441. (206 aa) |
| | fabD | Malonyl coenzyme A-acyl carrier protein transacylase; Alternative locus ID: PMED4_01431. (298 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (335 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity). (466 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (214 aa) |
| | holB | DNA polymerase III, delta prime subunit; Alternative locus ID: PMED4_01351. (319 aa) |
| | cysK2 | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_01291; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa) |
| | PMM0110 | Putative glutathione S-transferase; Alternative locus ID: PMED4_01161. (241 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (185 aa) |
| | rimO | Possible Fe-S oxidoreductase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (454 aa) |
| | PMM0080 | Conserved hypothetical protein; Alternative locus ID: PMED4_00831. (226 aa) |
| | PMM0078 | Possible 4'-phosphopantetheinyl transferase family protein; Alternative locus ID: PMED4_00811; Belongs to the P-Pant transferase superfamily. (218 aa) |
| | PMM0070 | Putative cysteine desulfurase or selenocysteine lyase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (425 aa) |
| | PMM0059 | Conserved hypothetical protein; Alternative locus ID: PMED4_00611. (429 aa) |
| | PMM0053 | Putative RNA methylase family UPF0020; Alternative locus ID: PMED4_00541; Belongs to the methyltransferase superfamily. (374 aa) |
| | argJ | ArgJ family; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (402 aa) |
| | coaE | Putative dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (204 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (152 aa) |
