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gap2 gap2 accB,fabE accB,fabE PMM0052 PMM0052 accC, accC, pgm pgm cysH cysH hemD hemD cysK2 cysK2 PMM0153 PMM0153 gltA gltA cysC cysC pgk, pgk, eno eno PMM0215 PMM0215 PMM0225 PMM0225 cysD cysD glyA glyA PMM0331 PMM0331 pdhC pdhC cysK1 cysK1 mqo mqo gltX gltX hemL, hemL, hemC hemC cobC cobC tal tal accA accA rbcL, rbcL, rbcS, rbcS, thrB thrB PMM0596 PMM0596 PMM0614 PMM0614 acs acs gap1 gap1 sir sir rpe, rpe, glpX, glpX, hemA hemA gnd gnd pgl pgl CbbA CbbA accD accD prk, prk, PMM0808 PMM0808 tpi, tpi, dapB dapB PMM0874 PMM0874 dapF dapF pgi pgi pykF pykF spt, spt, glnA glnA pdhB pdhB ureC ureC ureB ureB ureA ureA thrA,hom thrA,hom folD folD zwf zwf kprS kprS cad cad lysA lysA PMM1192 PMM1192 PMM1215 PMM1215 PMM1229 PMM1229 PMM1234 PMM1234 PMM1235 PMM1235 PMM1236 PMM1236 pdhA pdhA lpdA lpdA argD argD serA serA PMM1358 PMM1358 pgmI pgmI fumC fumC rpiA, rpiA, glsF, glsF, ppc ppc icd icd tktA, tktA, cysE cysE lysC lysC dapA dapA asd asd cobA cobA acnB acnB thrC thrC
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
gap2Glyceraldehyde 3-phosphate dehydrogenase(NADP+)(phosphorylating); Citation: AJ245541; Mol Biol Evol 2001 Dec;18(12):2240-2249; Alternative locus ID: PMED4_00221; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
accB,fabEBiotin / Lipoyl attachment:Acetyl-CoA biotin carboxyl carrier subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (168 aa)
PMM0052Aldo/keto reductase family; Alternative locus ID: PMED4_00521. (320 aa)
accC,acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
pgmPhosphoglucomutase; Alternative locus ID: PMED4_00791. (545 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (240 aa)
hemDPutative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (269 aa)
cysK2O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_01291; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
PMM0153Conserved hypothetical protein; Alternative locus ID: PMED4_01591; Belongs to the methylenetetrahydrofolate reductase family. (296 aa)
gltACitrate synthase; Alternative locus ID: PMED4_01671; Belongs to the citrate synthase family. (381 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (208 aa)
pgk,Phosphoglycerate kinase; Alternative locus ID: PMED4_02011; Belongs to the phosphoglycerate kinase family. (402 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
PMM0215Delta-aminolevulinic acid dehydratase; Alternative locus ID: PMED4_02211; Belongs to the ALAD family. (333 aa)
PMM0225Possible 2-keto-3-deoxy-6-phosphogluconate aldolase; Alternative locus ID: PMED4_02301. (213 aa)
cysDATP-sulfurylase; Alternative locus ID: PMED4_02321. (391 aa)
glyASerine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa)
PMM0331Putative aldehyde dehydrogenase; Alternative locus ID: PMED4_03381; Belongs to the aldehyde dehydrogenase family. (463 aa)
pdhCDihydrolipoamide acetyltransferase component (E2) of pyruvate de; Alternative locus ID: PMED4_04481. (455 aa)
cysK1O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_04501; Belongs to the cysteine synthase/cystathionine beta- synthase family. (328 aa)
mqoPutative malate/quinone oxidoreductase; Alternative locus ID: PMED4_04631. (475 aa)
gltXGlutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (478 aa)
hemL,Glutamate-1-semialdehyde 2,1-aminomutase; Alternative locus ID: PMED4_05321; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (433 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (316 aa)
cobCPossible alpha-ribazole-5'-P phosphatase; Phosphatase involved in the assembly of the nucleotide loop of cobalamin; Citation: O'Toole et al. (1994) J. Biol. Chem. 269:26503-26511; Alternative locus ID: PMED4_05641; Belongs to the phosphoglycerate mutase family. (442 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (333 aa)
accAacetyl-CoA carboxylase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (335 aa)
rbcL,Ribulose bisphosphate carboxylase, large chain; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site. Belongs to the RuBisCO large chain family. Type I subfamily. (471 aa)
rbcS,Ribulose bisphosphate carboxylase, small chain; Alternative locus ID: PMED4_06001. (113 aa)
thrBHomoserine kinase:GHMP kinases putative ATP-binding domain; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (315 aa)
PMM0596Putative glucokinase; Alternative locus ID: PMED4_06451; Belongs to the bacterial glucokinase family. (345 aa)
PMM0614Conserved hypothetical protein; Probable pseudogene due to N-terminal truncation - MIT9313 and WH8102 have a longer form (with other homologs) and also have an additional gene upstream before aroA; Alternative locus ID: PMED4_06631; Belongs to the ComB family. (207 aa)
acsAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
gap1Putative glyceraldehyde 3-phosphate dehydrogenase; Alternative locus ID: PMED4_07871; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa)
sirFerredoxin-sulfite reductase; Alternative locus ID: PMED4_08431; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (596 aa)
rpe,Ribulose-phosphate 3-epimerase; Alternative locus ID: PMED4_08511. (251 aa)
glpX,Fructose-1,6-bisphosphatase/sedoheptulose-1, 7-bisphosphatase; Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6- phosphate and sedoheptulose 7-phosphate, respectively; Belongs to the FBPase class 2 family. (333 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (433 aa)
gnd6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (472 aa)
pglPutative 6-phosphogluconolactonase (DevB, Pgl); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (245 aa)
CbbAFructose-bisphosphate/sedoheptulose-1, 7-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (357 aa)
accDacetyl-CoA carboxylase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (292 aa)
prk,Phosphoribulokinase; Alternative locus ID: PMED4_08711. (299 aa)
PMM0808Rieske iron-sulfur protein 2Fe-2S subunit; Alternative locus ID: PMED4_08941. (440 aa)
tpi,Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (230 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (282 aa)
PMM0874Possible ATP adenylyltransferase; Alternative locus ID: PMED4_09851. (276 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (286 aa)
pgiPhosphoglucose isomerase (PGI); Alternative locus ID: PMED4_10011. (526 aa)
pykFPyruvate kinase; Alternative locus ID: PMED4_10231; Belongs to the pyruvate kinase family. (596 aa)
spt,Class-V aminotransferase; Alternative locus ID: PMED4_10301. (394 aa)
glnAGlutamine synthetase, glutamate--ammonia ligase; Alternative locus ID: PMED4_10311. (473 aa)
pdhBPyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
ureCUrease alpha subunit; Citation: Palinska et al. (2000) Microbiology 146:3099-3107; Alternative locus ID: PMED4_10751; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (569 aa)
ureBUrease beta subunit; Citation: Palinska et al. (2000) Microbiology 146:3099-3107; Alternative locus ID: PMED4_10761; Belongs to the urease beta subunit family. (106 aa)
ureAUrease gamma subunit; Citation: Palinska et al. (2000) Microbiology 146:3099-3107; Alternative locus ID: PMED4_10771; Belongs to the urease gamma subunit family. (100 aa)
thrA,homHomoserine dehydrogenase:ACT domain; Putative assignment; Alternative locus ID: PMED4_11971. (433 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (507 aa)
kprSRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (331 aa)
cadOrn/Lys/Arg decarboxylases family 1; Possible assignment; Alternative locus ID: PMED4_12301. (465 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (457 aa)
PMM1192CysQ protein homolog; Alternative locus ID: PMED4_13571. (313 aa)
PMM1215Conserved hypothetical protein; Alternative locus ID: PMED4_13801. (407 aa)
PMM1229Dehydrogenase, E1 component; Alternative locus ID: PMED4_13941. (324 aa)
PMM1234Zinc-containing alcohol dehydrogenase superfamily; Alternative locus ID: PMED4_13991. (343 aa)
PMM1235Possible N-terminal fragment of transketolase; Alternative locus ID: PMED4_14001. (276 aa)
PMM1236Unknown; Alternative locus ID: PMED4_14011. (305 aa)
pdhAPyruvate dehydrogenase E1 alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (345 aa)
lpdAPutative dihydrolipoamide dehydrogenase; Alternative locus ID: PMED4_14641. (479 aa)
argDN-acetylornithine aminotransferase; Alternative locus ID: PMED4_14681; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (417 aa)
serAPutative D-3-phosphoglycerate dehydrogenase (PGDH); Alternative locus ID: PMED4_15221; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa)
PMM1358Conserved hypothetical protein; Alternative locus ID: PMED4_15261. (183 aa)
pgmIPhosphoglycerate mutase, co-factor-independent (iPGM); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (540 aa)
fumCFumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
rpiA,Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (231 aa)
glsF,Ferredoxin-dependent glutamate synthase, Fd-GOGAT; Alternative locus ID: PMED4_17221. (1521 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (989 aa)
icdIsocitrate dehydrogenase; Alternative locus ID: PMED4_18061. (474 aa)
tktA,Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (668 aa)
cysESerine acetyltransferase; Alternative locus ID: PMED4_18481. (244 aa)
lysCAspartate kinase; Putative assignment; alpha and beta subunits, and additional region with similarity to beta subunit (BY SIMILARITY); Alternative locus ID: PMED4_18581. (586 aa)
dapADihydrodipicolinate synthetase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (302 aa)
asdAspartate Semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa)
cobAPutative uroporphyrin-III C-methyltransferase; 2 S-ADENOSYL-L-METHIONINE + UROPORPHYRIN III = 2 S-ADENOSYL-L-HOMOCYSTEINE + SIROHYDROCHLORIN; Citation: Crouzet et al. (199) J. Bacteriol. 172:5968-5979; Blanche et al. (1989) J. Bacteriol. 171:4222-4231 (1989); Alternative locus ID: PMED4_19051; Belongs to the precorrin methyltransferase family. (261 aa)
acnBAconitate hydratase B; Alternative locus ID: PMED4_19111; Belongs to the aconitase/IPM isomerase family. (857 aa)
thrCThreonine synthase: Pyridoxal-5'-phosphate-dependent enzymes, beta family; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (367 aa)
Your Current Organism:
Prochlorococcus marinus pastoris
NCBI taxonomy Id: 59919
Other names: P. marinus subsp. pastoris str. CCMP1986, Prochlorococcus marinus MED4, Prochlorococcus marinus subsp. pastoris str. CCMP1378, Prochlorococcus marinus subsp. pastoris str. CCMP1986, Prochlorococcus sp. CCMP1378, Prochlorococcus sp. MED4
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