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| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (354 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (271 aa) |
| | hisI | phosphoribosyl-ATP pyrophosphatase / phosphoribosyl-AMP cyclohydrolase; Alternative locus ID: NATL2_06171; In the N-terminal section; belongs to the PRA-CH family. (214 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (315 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (444 aa) |
| | AAZ57571.1 | Glucosylglycerol phosphatase; Alternative locus ID: NATL2_06841. (399 aa) |
| | AAZ57572.1 | Conserved hypothetical protein; Alternative locus ID: NATL2_06851. (513 aa) |
| | AAZ57573.1 | Conserved hypothetical protein; Alternative locus ID: NATL2_06861. (387 aa) |
| | AAZ57574.1 | Conserved hypothetical protein; Alternative locus ID: NATL2_06871. (231 aa) |
| | AAZ57575.1 | O-acetylhomoserine sulfhydrolase; Alternative locus ID: NATL2_06881. (452 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (297 aa) |
| | AAZ57598.1 | L-aspartate aminotransferase apoenzyme; Alternative locus ID: NATL2_07121. (392 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (368 aa) |
| | purK | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (381 aa) |
| | AAZ57633.1 | L-glutamine synthetase; Alternative locus ID: NATL2_07551. (473 aa) |
| | AAZ57654.1 | Sulfite reductase (ferredoxin); Alternative locus ID: NATL2_07761; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (601 aa) |
| | ilvD | Dihydroxyacid dehydratase; Alternative locus ID: NATL2_07941; Belongs to the IlvD/Edd family. (556 aa) |
| | AAZ57674.1 | Uracil phosphoribosyltransferase; Alternative locus ID: NATL2_07961. (205 aa) |
| | purS | Phosphoribosylformylglycinamidine synthetase PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to ass [...] (90 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (217 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (359 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Alternative locus ID: NATL2_08171. (256 aa) |
| | AAZ57714.1 | Asparaginase; Alternative locus ID: NATL2_08351. (320 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit; Alternative locus ID: NATL2_08401; Belongs to the CarB family. (1102 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa) |
| | carA | Carbamoyl-phosphate synthase small subunit; Alternative locus ID: NATL2_08751; Belongs to the CarA family. (384 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (511 aa) |
| | AAZ57800.1 | Inositol-1(or 4)-monophosphatase; Alternative locus ID: NATL2_09271; Belongs to the inositol monophosphatase superfamily. (288 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (359 aa) |
| | purN | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (232 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (284 aa) |
| | ilvE | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (304 aa) |
| | AAZ57825.1 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1182 aa) |
| | AAZ57827.1 | Possible ATP adenylyltransferase; Alternative locus ID: NATL2_09551. (278 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (282 aa) |
| | AAZ57880.1 | Uridine kinase; Alternative locus ID: NATL2_10161. (204 aa) |
| | purT | Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (387 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (454 aa) |
| | folD | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (303 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (539 aa) |
| | AAZ58181.1 | IMP dehydrogenase related 2; Alternative locus ID: NATL2_14631. (387 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (209 aa) |
| | AAZ58193.1 | Homoserine dehydrogenase; Alternative locus ID: NATL2_14771. (438 aa) |
| | AAZ58255.1 | Acetolactate synthase, small subunit; Alternative locus ID: NATL2_15431. (167 aa) |
| | AAZ58302.1 | CysQ protein-like protein; Alternative locus ID: NATL2_15991. (304 aa) |
| | AAZ58312.1 | Phosphoribosylglycinamide formyltransferase; Alternative locus ID: NATL2_16091. (130 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (318 aa) |
| | surE | Exopolyphosphatase / 3'-nucleotidase / 5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (262 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Alternative locus ID: NATL2_16581; Belongs to the TrpC family. (295 aa) |
| | argD | Acetylornithine aminotransferase apoenzyme; Alternative locus ID: NATL2_16631; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (393 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (272 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (241 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternative locus ID: NATL2_17091; Belongs to the SAICAR synthetase family. (247 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Alternative locus ID: NATL2_17101; Belongs to the GARS family. (434 aa) |
| | AAZ58483.1 | Nitrogen regulatory protein P-II; Alternative locus ID: NATL2_18041; Belongs to the P(II) protein family. (112 aa) |
| | AAZ58486.1 | Adenylosuccinate lyase; Alternative locus ID: NATL2_18071; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (449 aa) |
| | dapL | LL-diaminopimelate aminotransferase apoenzyme; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (408 aa) |
| | pheA | Prephenate dehydratase; Alternative locus ID: NATL2_18871. (276 aa) |
| | AAZ58568.1 | Glutamate synthase (ferredoxin); Alternative locus ID: NATL2_18951. (1529 aa) |
| | AAZ58626.1 | Arogenate dehydrogenase (NADP); Alternative locus ID: NATL2_19571. (291 aa) |
| | AAZ58639.1 | Anthranilate synthase, component I; Alternative locus ID: NATL2_19701. (506 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; Alternative locus ID: NATL2_19861. (346 aa) |
| | panC/cmk | Cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. (516 aa) |
| | AAZ58691.1 | DedA family; Alternative locus ID: NATL2_20231. (218 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (477 aa) |
| | AAZ58707.1 | Serine O-acetyltransferase; Alternative locus ID: NATL2_20391. (246 aa) |
| | AAZ58721.1 | Acetyltransferase; Alternative locus ID: NATL2_20541. (156 aa) |
| | AAZ58722.1 | TPR repeat; Alternative locus ID: NATL2_20551. (750 aa) |
| | AAZ58736.1 | Aspartate kinase; Alternative locus ID: NATL2_20711. (588 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (302 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (345 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (555 aa) |
| | AAZ58784.1 | Anthranilate synthase, component I; Alternative locus ID: NATL2_21211. (446 aa) |
| | AAZ58785.1 | Aminotransferases class-IV; Alternative locus ID: NATL2_21221. (275 aa) |
| | AAZ58788.1 | Assimilatory nitrite reductase (ferredoxin) precursor; Alternative locus ID: NATL2_21261; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (553 aa) |
| | AAZ58789.1 | Formate and nitrite transporter; Alternative locus ID: NATL2_21271. (303 aa) |
| | AAZ58791.1 | Unknown; Alternative locus ID: NATL2_21291; old function glycosyl transferase family. (352 aa) |
| | AAZ58797.1 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (311 aa) |
| | argG | Argininosuccinate synthase; Alternative locus ID: NATL2_21461; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (400 aa) |
| | AAZ58816.1 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (368 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (803 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (485 aa) |
| | argH | Argininosuccinate lyase; Alternative locus ID: NATL2_00111. (463 aa) |
| | argJ | N-acetylglutamate synthase / glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (420 aa) |
| | cynS | Cyanase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family. (147 aa) |
| | AAZ58933.1 | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (255 aa) |
| | AAZ58952.1 | Inositol monophosphatase family protein; Alternative locus ID: NATL2_01471. (272 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (198 aa) |
| | AAZ58978.1 | Cysteine synthase; Alternative locus ID: NATL2_01751; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (211 aa) |
| | AAZ59007.1 | Conserved hyopthetical protein; Alternative locus ID: NATL2_02051; Belongs to the methylenetetrahydrofolate reductase family. (293 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (417 aa) |
| | cysC | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (212 aa) |
| | purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (178 aa) |
| | AAZ59040.1 | Anthranilate synthase, component II; Alternative locus ID: NATL2_02401. (198 aa) |
| | AAZ59041.1 | Histidinol phosphate aminotransferase apoenzyme; Alternative locus ID: NATL2_02411. (371 aa) |
| | pyrD | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (385 aa) |
| | AAZ59079.1 | Aspartoacylase; Alternative locus ID: NATL2_02811; Belongs to the AspA/AstE family. Aspartoacylase subfamily. (305 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa) |
| | AAZ59084.1 | Sulfate adenylyltransferase; Alternative locus ID: NATL2_02871. (416 aa) |
| | pyrB | Aspartate carbamoyltransferase; Alternative locus ID: NATL2_02921; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (339 aa) |
| | AAZ59097.1 | Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (212 aa) |
| | AAZ59098.1 | Deoxycytidine triphosphate deaminase; Alternative locus ID: NATL2_03021. (197 aa) |
| | AAZ59109.1 | 3-isopropylmalate dehydratase, small subunit; Alternative locus ID: NATL2_03131; Belongs to the LeuD family. (206 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | AAZ59111.1 | Competence/damage-inducible protein cinA; Alternative locus ID: NATL2_03151; Belongs to the CinA family. (430 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa) |
| | AAZ59117.1 | Ammonium transporter; Alternative locus ID: NATL2_03211; TC 1.A.11. (496 aa) |
| | purH | IMP cyclohydrolase / phosphoribosylaminoimidazolecarboxamide formyltransferase; Alternative locus ID: NATL2_03241. (518 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (215 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Alternative locus ID: NATL2_03411. (203 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (409 aa) |
| | AAZ59229.1 | Cysteine synthase; Alternative locus ID: NATL2_04421; Belongs to the cysteine synthase/cystathionine beta- synthase family. (328 aa) |
| | AAZ59230.1 | Cystathionine gamma-synthase; Alternative locus ID: NATL2_04431. (488 aa) |
| | AAZ59231.1 | Cystathionine gamma-synthase; Alternative locus ID: NATL2_04441. (389 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (304 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (437 aa) |
| | AAZ59335.1 | Phosphoglycerate mutase; Alternative locus ID: NATL2_05541; Belongs to the phosphoglycerate mutase family. (442 aa) |
| | AAZ59346.1 | Acetolactate synthase, large subunit; Alternative locus ID: NATL2_05651. (582 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Alternative locus ID: NATL2_05741; Belongs to the TrpF family. (224 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (220 aa) |
