STRINGSTRING
ABM76781.1 ABM76781.1 dnaX dnaX uvrB uvrB holA holA gyrB gyrB mutY mutY ABM76933.1 ABM76933.1 ruvB ruvB topA topA xthA xthA sigA sigA ABM77481.1 ABM77481.1 priA priA dnaA dnaA polA polA ruvC ruvC gyrA gyrA recR recR ABM77733.1 ABM77733.1 sbcD sbcD sbcC sbcC ABM78173.1 ABM78173.1 uvrC uvrC dnaE dnaE ruvA ruvA dnaG dnaG umuC umuC umuD umuD nth nth ABM78567.1 ABM78567.1 dnaQ dnaQ lexA lexA ABM78702.1 ABM78702.1 recQ recQ recF recF recA recA uvrD uvrD holB holB sms sms dnaB dnaB lig lig uvrA uvrA recN recN ABM79751.1 ABM79751.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABM76781.1Uncharacterized protein conserved in bacteria; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (113 aa)
dnaXDNA polymerase, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (604 aa)
uvrBExcinuclease ABC subunit B (UvrB); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits diss [...] (679 aa)
holACOG1466 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]. (336 aa)
gyrBDNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (655 aa)
mutYProbable adenine glycosylase; COG1194 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]. (400 aa)
ABM76933.1COG629 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]. (128 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (398 aa)
topAProkaryotic DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removin [...] (916 aa)
xthACOG708 Exonuclease III [DNA replication, recombination, and repair]. (279 aa)
sigAPutative principal RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (444 aa)
ABM77481.1Hypothetical protein. (61 aa)
priAPrimosomal protein N' (replication factor Y); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (743 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (463 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (986 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (154 aa)
gyrADNA gyrase/topoisomerase IV, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-depend [...] (875 aa)
recRRecR protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (189 aa)
ABM77733.1Type II alternative RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (320 aa)
sbcDCOG420 DNA repair exonuclease [DNA replication, recombination, and repair]. (404 aa)
sbcCRecF protein:ABC transporter; COG419 ATPase involved in DNA repair [DNA replication, recombination, and repair]. (918 aa)
ABM78173.1Putative type III sigma factor; COG1191 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Belongs to the sigma-70 factor family. (269 aa)
uvrCExcinuclease ABC subunit C (UvrC); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (667 aa)
dnaECOG587 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]. (1171 aa)
ruvAPutative holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (233 aa)
dnaGCHC2 zinc finger:Toprim domain; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (684 aa)
umuCPutative UmuC protein; COG389 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]. (424 aa)
umuDPutative SOS mutagenesis protein UmuD; COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Belongs to the peptidase S24 family. (158 aa)
nthPutative endonuclease; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (217 aa)
ABM78567.1Putative type II alternative sigma factor, sigma70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (308 aa)
dnaQCOG847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]. (321 aa)
lexASOS function regulatory protein, LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (198 aa)
ABM78702.1Type II alternative RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (313 aa)
recQCOG514 Superfamily II DNA helicase [DNA replication, recombination, and repair]. (497 aa)
recFPutative DNA repair and genetic recombination protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (352 aa)
recARecA bacterial DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (379 aa)
uvrDUvrD/REP helicase; COG210 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]. (802 aa)
holBDNA polymerase III, delta prime subunit. (326 aa)
smsPutative DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (464 aa)
dnaBDnaB replicative helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (472 aa)
ligNAD-dependent DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (696 aa)
uvrAExcinuclease ABC, A subunit, ATP/GTP-binding site motif A (P-loop):ABC transporter; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (991 aa)
recNDNA repair protein RecN, ABC transporter; May be involved in recombinational repair of damaged DNA. (562 aa)
ABM79751.1Possible protein kinase:ABC1 family protein; COG661 Predicted unusual protein kinase [General function prediction only]. (629 aa)
Your Current Organism:
Prochlorococcus marinus MIT9303
NCBI taxonomy Id: 59922
Other names: P. marinus str. MIT 9303, Prochlorococcus marinus str. MIT 9303, Prochlorococcus sp. MIT 9303, Prochlorococcus sp. MIT9303
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