STRINGSTRING
plsX plsX fabH fabH fabD fabD ABM79387.1 ABM79387.1 gltA gltA argJ argJ ABM79722.1 ABM79722.1 ABM76848.1 ABM76848.1 ABM76869.1 ABM76869.1 cysE cysE ABM76965.1 ABM76965.1 fabZ fabZ lpxA lpxA plsY plsY ABM77404.1 ABM77404.1 qri7 qri7 pta pta ABM77455.1 ABM77455.1 ABM77576.1 ABM77576.1 leuA leuA ABM77706.1 ABM77706.1 ABM77741.1 ABM77741.1 ABM77833.1 ABM77833.1 metA metA lpxD lpxD ABM78482.1 ABM78482.1 ABM78499.1 ABM78499.1 ABM78545.1 ABM78545.1 bcsA bcsA glmU glmU lnt lnt pdhC pdhC lipB lipB fabI fabI fabF fabF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
plsXFatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (448 aa)
fabH3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (326 aa)
fabDCOG331 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]. (298 aa)
ABM79387.1COG204 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]. (234 aa)
gltACOG372 Citrate synthase [Energy production and conversion]; Belongs to the citrate synthase family. (396 aa)
argJArgJ family protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (427 aa)
ABM79722.1GCN5-related N-acetyltransferase. (161 aa)
ABM76848.1Putative acetyltransferase, GNAT family protein. (160 aa)
ABM76869.1Hypothetical protein; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]. (260 aa)
cysECOG1045 Serine acetyltransferase [Amino acid transport and metabolism]. (247 aa)
ABM76965.1COG3146 Uncharacterized protein conserved in bacteria [Function unknown]. (378 aa)
fabZPutative (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (135 aa)
lpxAUDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (283 aa)
plsYPredicted membrane protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (205 aa)
ABM77404.13-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (262 aa)
qri7Probable o-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (356 aa)
ptaCOG857 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]. (366 aa)
ABM77455.1Conserved hypothetical protein. (327 aa)
ABM77576.1COG456 Acetyltransferases [General function prediction only]. (166 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (540 aa)
ABM77706.1From 'motifs_6.msf'; COG204 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]. (245 aa)
ABM77741.1Putative ribosomal-protein-alanine acetyltransferase; COG456 Acetyltransferases [General function prediction only]. (161 aa)
ABM77833.1Hypothetical protein. (261 aa)
metAPutative homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (297 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (347 aa)
ABM78482.1Conserved hypothetical protein. (308 aa)
ABM78499.1GCN5-related N-acetyltransferase. (294 aa)
ABM78545.1GCN5-related N-acetyltransferase. (163 aa)
bcsACOG3424 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]. (364 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (470 aa)
lntPossible apolipoprotein n-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (491 aa)
pdhCDihydrolipoamide acetyltransferase; COG508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]. (439 aa)
lipBPutative lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (253 aa)
fabICOG623 Enoyl-[acyl-carrier-protein]. (268 aa)
fabF3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (415 aa)
Your Current Organism:
Prochlorococcus marinus MIT9303
NCBI taxonomy Id: 59922
Other names: P. marinus str. MIT 9303, Prochlorococcus marinus str. MIT 9303, Prochlorococcus sp. MIT 9303, Prochlorococcus sp. MIT9303
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.