STRINGSTRING
ispE ispE coaE coaE ABM79538.1 ABM79538.1 pgk pgk ABM79501.1 ABM79501.1 dgkA dgkA cysC cysC ABM79432.1 ABM79432.1 ABM79429.1 ABM79429.1 nadK-2 nadK-2 cugP cugP ABM79391.1 ABM79391.1 tmk tmk holB holB manC manC ABM79311.1 ABM79311.1 kdsB kdsB ABM79280.1 ABM79280.1 ABM79278.1 ABM79278.1 ABM79254.1 ABM79254.1 folK folK cobS cobS ABM79219.1 ABM79219.1 rfe rfe rph rph ABM79172.1 ABM79172.1 met3 met3 rpoA rpoA adk adk ABM79027.1 ABM79027.1 ABM79005.1 ABM79005.1 panC panC xylB xylB ABM78857.1 ABM78857.1 ABM78817.1 ABM78817.1 ABM78809.1 ABM78809.1 ABM78778.1 ABM78778.1 ABM78777.1 ABM78777.1 ribF ribF nadK nadK dnaQ dnaQ glmU glmU glk glk thrB thrB ABM78586.1 ABM78586.1 pgsA pgsA proB proB prkB prkB glgC glgC rsbW rsbW ndk ndk ABM78346.1 ABM78346.1 dnaG dnaG dnaE dnaE ABM78325.1 ABM78325.1 pykF pykF coaD coaD apa2 apa2 cobU cobU ABM78202.1 ABM78202.1 ABM78153.1 ABM78153.1 ABM78152.1 ABM78152.1 ABM78075.1 ABM78075.1 ABM78069.1 ABM78069.1 ABM78062.1 ABM78062.1 ABM78009.1 ABM78009.1 ABM77987.1 ABM77987.1 phoR phoR ABM77834.1 ABM77834.1 dacA dacA cdsA cdsA ABM77734.1 ABM77734.1 prsA prsA ABM77715.1 ABM77715.1 sasA sasA polA polA pyrH pyrH ABM77492.1 ABM77492.1 argB argB gmk gmk ispD ispD pnp pnp ABM77329.1 ABM77329.1 nblS nblS kaiC kaiC rpoZ rpoZ nadD nadD rpoC2 rpoC2 rpoC1 rpoC1 rpoB rpoB ABM77072.1 ABM77072.1 ABM77017.1 ABM77017.1 ABM77015.1 ABM77015.1 anmK anmK aroK aroK ABM76946.1 ABM76946.1 ABM76928.1 ABM76928.1 ABM76894.1 ABM76894.1 ABM76872.1 ABM76872.1 ABM76870.1 ABM76870.1 rfaE rfaE ABM76853.1 ABM76853.1 holA holA lysC lysC dnaX dnaX thiL thiL dnaN dnaN ABM79751.1 ABM79751.1 mraY mraY sec59 sec59 ppk ppk ABM79676.1 ABM79676.1 ABM79674.1 ABM79674.1 ABM79672.1 ABM79672.1 ABM79597.1 ABM79597.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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gene neighborhood
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gene co-occurrence
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ispEPutative 4-diphosphocytidyl-2C-methyl-D-erythritol kinase (CMK); Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (319 aa)
coaEPutative dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (244 aa)
ABM79538.1COG397 Uncharacterized conserved protein [Function unknown]. (493 aa)
pgkCOG126 3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; Belongs to the phosphoglycerate kinase family. (401 aa)
ABM79501.1Possible kinase; COG661 Predicted unusual protein kinase [General function prediction only]. (559 aa)
dgkACOG818 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]. (152 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (227 aa)
ABM79432.1Hypothetical protein. (110 aa)
ABM79429.1Hypothetical protein. (302 aa)
nadK-2Predicted inorganic polyphosphate / ATP-NAD+ kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (315 aa)
cugPPutative sugar-phosphate nucleotidyl transferase; Catalyzes the formation of UDP-glucose, from UTP and glucose 1-phosphate. (392 aa)
ABM79391.1COG617 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (412 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (216 aa)
holBDNA polymerase III, delta prime subunit. (326 aa)
manCCOG836 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Belongs to the mannose-6-phosphate isomerase type 2 family. (484 aa)
ABM79311.1COG3395 Uncharacterized protein conserved in bacteria [Function unknown]. (480 aa)
kdsBPutative 3-deoxy-manno-octulosonate cytidylyltransferase; COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase [Cell envelope biogenesis, outer membrane]. (271 aa)
ABM79280.1COG617 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (415 aa)
ABM79278.1Selenide,water dikinase; COG1252 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]. (730 aa)
ABM79254.1Uncharacterized conserved protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (496 aa)
folKPossible 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; COG801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism]. (248 aa)
cobSCobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (260 aa)
ABM79219.1COG642 Signal transduction histidine kinase [Signal transduction mechanisms]. (379 aa)
rfeGlycosyl transferase, family 4; COG472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]. (382 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (244 aa)
ABM79172.1COG2971 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]. (320 aa)
met3ATP-sulfurylase; COG2046 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]. (390 aa)
rpoABacterial RNA polymerase, alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (312 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (182 aa)
ABM79027.1COG3001 Uncharacterized protein conserved in bacteria [Function unknown]; Belongs to the fructosamine kinase family. (287 aa)
ABM79005.1COG642 Signal transduction histidine kinase [Signal transduction mechanisms]. (463 aa)
panCPanthothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. (488 aa)
xylBCarbohydrate kinase, FGGY family protein; COG1070 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]. (427 aa)
ABM78857.1Hypothetical protein. (239 aa)
ABM78817.1COG642 Signal transduction histidine kinase [Signal transduction mechanisms]. (496 aa)
ABM78809.1Hypothetical protein. (140 aa)
ABM78778.1Hypothetical protein. (164 aa)
ABM78777.1COG3063 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]. (233 aa)
ribFPutative riboflavin kinase/FAD synthase; COG196 FAD synthase [Coenzyme metabolism]; Belongs to the ribF family. (310 aa)
nadKPredicted sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (302 aa)
dnaQCOG847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]. (321 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (470 aa)
glkCOG837 Glucokinase [Carbohydrate transport and metabolism]; Belongs to the bacterial glucokinase family. (353 aa)
thrBHomoserine kinase:GHMP kinases putative ATP-binding domain; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (316 aa)
ABM78586.1ROK family protein; COG1940 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]. (304 aa)
pgsACDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase; COG558 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (189 aa)
proBPutative glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (361 aa)
prkBCOG3954 Phosphoribulokinase [Energy production and conversion]. (300 aa)
glgCCOG448 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (431 aa)
rsbWCOG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]. (164 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (152 aa)
ABM78346.1Hypothetical protein. (66 aa)
dnaGCHC2 zinc finger:Toprim domain; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (684 aa)
dnaECOG587 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]. (1171 aa)
ABM78325.1Conserved hypothetical protein. (98 aa)
pykFCOG469 Pyruvate kinase [Carbohydrate transport and metabolism]; Belongs to the pyruvate kinase family. (605 aa)
coaDPutative pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (157 aa)
apa2COG4360 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]. (281 aa)
cobUCOG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme metabolism]. (186 aa)
ABM78202.1COG4240 Predicted kinase [General function prediction only]. (352 aa)
ABM78153.1COG2326 Uncharacterized conserved protein [Function unknown]. (309 aa)
ABM78152.1COG642 Signal transduction histidine kinase [Signal transduction mechanisms]. (444 aa)
ABM78075.1Conserved hypothetical protein. (371 aa)
ABM78069.1CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (271 aa)
ABM78062.1COG2187 Uncharacterized protein conserved in bacteria [Function unknown]. (556 aa)
ABM78009.1Hypothetical protein. (107 aa)
ABM77987.1COG524 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]. (283 aa)
phoRTwo-component sensor histidine kinase, phosphate sensing; COG642 Signal transduction histidine kinase [Signal transduction mechanisms]. (361 aa)
ABM77834.1Hypothetical protein; Belongs to the P-Pant transferase superfamily. (192 aa)
dacAUncharacterized conserved protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (293 aa)
cdsAPhosphatidate cytidylyltransferase; COG575 CDP-diglyceride synthetase [Lipid metabolism]; Belongs to the CDS family. (304 aa)
ABM77734.1Possible kinase; COG661 Predicted unusual protein kinase [General function prediction only]. (564 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (337 aa)
ABM77715.1Possible sugar-phosphate nucleotidyl transferase; COG662 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]. (127 aa)
sasATwo-component sensor histidine kinase; May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs. (370 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (986 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (237 aa)
ABM77492.1COG524 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]. (342 aa)
argBAspartokinase superfamily:Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (308 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (192 aa)
ispDPutative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (248 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (721 aa)
ABM77329.1COG397 Uncharacterized conserved protein [Function unknown]. (567 aa)
nblSCOG5002 Signal transduction histidine kinase [Signal transduction mechanisms]. (685 aa)
kaiCPossible circadian clock protein KaiC; Core component of the KaiBC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiBC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction; Belongs to the KaiC family. (488 aa)
rpoZPutative DNA-directed RNA polymerase (omega chain); Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (70 aa)
nadDPutative nicotinate-nucleotide adenylyltransferase; COG1057 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Belongs to the NadD family. (194 aa)
rpoC2RNA polymerase beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily. (1374 aa)
rpoC1RNA polymerase gamma subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (634 aa)
rpoBRNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1097 aa)
ABM77072.1Conserved hypothetical protein. (326 aa)
ABM77017.1Possible 4'-phosphopantetheinyl transferase family protein. (217 aa)
ABM77015.1COG1521 Putative transcriptional regulator, homolog of Bvg accessory factor [Transcription]. (251 aa)
anmKPredicted molecular chaperone; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (379 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (192 aa)
ABM76946.1COG515 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms. (640 aa)
ABM76928.1COG524 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]. (346 aa)
ABM76894.1Glucose-1-phosphate cytidylyltransferase; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure an. (255 aa)
ABM76872.1COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis]. (320 aa)
ABM76870.1COG1083 CMP-N-acetylneuraminic acid synthetase [Cell envelope biogenesis, outer membrane]. (238 aa)
rfaEPutative ADP-heptose synthase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (503 aa)
ABM76853.1Putative sugar-phosphate nucleotidyl transferase; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure an. (252 aa)
holACOG1466 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]. (336 aa)
lysCCOG527 Aspartokinases [Amino acid transport and metabolism]. (595 aa)
dnaXDNA polymerase, gamma and tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (604 aa)
thiLPutative thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (327 aa)
dnaNDNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] (388 aa)
ABM79751.1Possible protein kinase:ABC1 family protein; COG661 Predicted unusual protein kinase [General function prediction only]. (629 aa)
mraYPutative phospho-N-acetylmuramoyl-pentapeptide-transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (373 aa)
sec59COG170 Dolichol kinase [Lipid metabolism]. (201 aa)
ppkPutative Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (712 aa)
ABM79676.1Hypothetical protein. (99 aa)
ABM79674.1Hypothetical protein. (693 aa)
ABM79672.1Hypothetical protein; COG1213 Predicted sugar nucleotidyltransferases [Cell envelope biogenesis, outer membrane]. (244 aa)
ABM79597.1COG515 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms. (444 aa)
Your Current Organism:
Prochlorococcus marinus MIT9303
NCBI taxonomy Id: 59922
Other names: P. marinus str. MIT 9303, Prochlorococcus marinus str. MIT 9303, Prochlorococcus sp. MIT 9303, Prochlorococcus sp. MIT9303
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