STRINGSTRING
ABM79279.1 ABM79279.1 kdsB kdsB ABM79285.1 ABM79285.1 kdsA kdsA ABM79320.1 ABM79320.1 acpP acpP fabF fabF ABM79340.1 ABM79340.1 crtQ crtQ ABM79368.1 ABM79368.1 plsX plsX fabH fabH fabD fabD ABM79387.1 ABM79387.1 crtB crtB pds pds ABM79399.1 ABM79399.1 menE menE dgkA dgkA murG murG accB accB sqdB sqdB ABM76820.1 ABM76820.1 ABM76869.1 ABM76869.1 ABM76876.1 ABM76876.1 ABM76878.1 ABM76878.1 ABM76879.1 ABM76879.1 ABM77033.1 ABM77033.1 accC accC ABM77076.1 ABM77076.1 ABM77125.1 ABM77125.1 lpxC lpxC fabZ fabZ lpxA lpxA lpxB lpxB plsY plsY cysQ cysQ ABM77369.1 ABM77369.1 ABM77371.1 ABM77371.1 ABM77404.1 ABM77404.1 ABM77406.1 ABM77406.1 ispD ispD accA accA ABM77614.1 ABM77614.1 dxr dxr ABM77623.1 ABM77623.1 ABM77667.1 ABM77667.1 ispA ispA ABM77706.1 ABM77706.1 lipA lipA cdsA cdsA uppS uppS crtH crtH ABM77932.1 ABM77932.1 ABM78069.1 ABM78069.1 gcpE gcpE ABM78266.1 ABM78266.1 dxs dxs ispE ispE accD accD lpxD lpxD pgsA pgsA glmU glmU sds sds ABM78667.1 ABM78667.1 trmD trmD ABM78815.1 ABM78815.1 fadD fadD ABM79028.1 ABM79028.1 ABM79086.1 ABM79086.1 lipA-2 lipA-2 rfe rfe lytB lytB ABM79236.1 ABM79236.1 ABM79239.1 ABM79239.1 ABM79242.1 ABM79242.1 fabI fabI ABM79248.1 ABM79248.1 ABM79282.1 ABM79282.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABM79279.1Hypothetical protein. (509 aa)
kdsBPutative 3-deoxy-manno-octulosonate cytidylyltransferase; COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase [Cell envelope biogenesis, outer membrane]. (271 aa)
ABM79285.1Conserved hypothetical protein. (237 aa)
kdsACOG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Belongs to the KdsA family. (300 aa)
ABM79320.1Hypothetical protein; COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]. (570 aa)
acpPAcyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. (103 aa)
fabF3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (415 aa)
ABM79340.1COG463 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]. (367 aa)
crtQZeta-carotene desaturase; Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'. (490 aa)
ABM79368.1Dolichyl-phosphate-mannose- proteinmannosyltransferase. (515 aa)
plsXFatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (448 aa)
fabH3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (326 aa)
fabDCOG331 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]. (298 aa)
ABM79387.1COG204 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]. (234 aa)
crtBCOG1562 Phytoene/squalene synthetase [Lipid metabolism]. (313 aa)
pdsPhytoene desaturase; COG3349 Uncharacterized conserved protein [Function unknown]. (472 aa)
ABM79399.1COG4094 Predicted membrane protein [Function unknown]. (278 aa)
menEProbable O-succinylbenzoic acid--CoA ligase (OSB-CoA synthetase); COG318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]. (411 aa)
dgkACOG818 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]. (152 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (361 aa)
accBBiotin / Lipoyl attachment:Acetyl-CoA biotin carboxyl carrier subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (164 aa)
sqdBSulfolipid (UDP-sulfoquinovose) biosynthesis protein; COG451 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]. (398 aa)
ABM76820.1COG1215 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]. (443 aa)
ABM76869.1Hypothetical protein; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]. (260 aa)
ABM76876.1Hypothetical protein. (676 aa)
ABM76878.1COG2604 Uncharacterized protein conserved in bacteria [Function unknown]. (673 aa)
ABM76879.1Hypothetical protein. (671 aa)
ABM77033.1Hypothetical protein. (56 aa)
accCacetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
ABM77076.1COG763 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]. (451 aa)
ABM77125.1Hypothetical protein; COG1233 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]. (938 aa)
lpxCUDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (285 aa)
fabZPutative (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (135 aa)
lpxAUDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (283 aa)
lpxBLipid-A-disaccharide synthetase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (392 aa)
plsYPredicted membrane protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (205 aa)
cysQCysQ; COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase [Inorganic ion transport and metabolism]. (334 aa)
ABM77369.1COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]. (613 aa)
ABM77371.1Hypothetical protein. (72 aa)
ABM77404.13-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (262 aa)
ABM77406.1COG859 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]. (352 aa)
ispDPutative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (248 aa)
accAacetyl-CoA carboxylase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (329 aa)
ABM77614.1COG429 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]. (370 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (412 aa)
ABM77623.1Hypothetical protein. (516 aa)
ABM77667.1Putative lycopene beta cyclase; COG654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism. (408 aa)
ispAPolyprenyl synthetase; COG142 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Belongs to the FPP/GGPP synthase family. (306 aa)
ABM77706.1From 'motifs_6.msf'; COG204 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]. (245 aa)
lipALipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (306 aa)
cdsAPhosphatidate cytidylyltransferase; COG575 CDP-diglyceride synthetase [Lipid metabolism]; Belongs to the CDS family. (304 aa)
uppSUndecaprenyl pyrophosphate synthetase (UPPS); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (265 aa)
crtHPutative carotenoid isomerase; COG1233 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]. (520 aa)
ABM77932.1Zeta-carotene desaturase-like protein; COG3349 Uncharacterized conserved protein [Function unknown]. (543 aa)
ABM78069.1CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (271 aa)
gcpEGcpE protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (406 aa)
ABM78266.1Hypothetical protein; COG483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]. (295 aa)
dxs1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (644 aa)
ispEPutative 4-diphosphocytidyl-2C-methyl-D-erythritol kinase (CMK); Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (319 aa)
accDacetyl-CoA carboxylase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (293 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (347 aa)
pgsACDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase; COG558 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (189 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (470 aa)
sdsPolyprenyl synthetase; COG142 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Belongs to the FPP/GGPP synthase family. (323 aa)
ABM78667.1COG4354 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]. (837 aa)
trmDPutative bifunctional enzyme: tRNA methyltransferase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP); Belongs to the RNA methyltransferase TrmD family. (410 aa)
ABM78815.1Hypothetical protein; COG688 Phosphatidylserine decarboxylase [Lipid metabolism]; Belongs to the phosphatidylserine decarboxylase family. (397 aa)
fadDPutative long-chain-fatty-acid--CoA ligase; COG1022 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]. (621 aa)
ABM79028.1COG1233 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]. (503 aa)
ABM79086.1Putative lycopene epsilon cyclase; COG644 Dehydrogenases (flavoproteins) [Energy production and conversion]. (426 aa)
lipA-2Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (294 aa)
rfeGlycosyl transferase, family 4; COG472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]. (382 aa)
lytBLytB; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (398 aa)
ABM79236.1Hypothetical protein. (64 aa)
ABM79239.1Hypothetical protein. (64 aa)
ABM79242.1Retinal pigment epithelial membrane protein; COG3670 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]. (507 aa)
fabICOG623 Enoyl-[acyl-carrier-protein]. (268 aa)
ABM79248.1COG5305 Predicted membrane protein [Function unknown]. (506 aa)
ABM79282.1COG1778 Low specificity phosphatase (HAD superfamily) [General function prediction only]. (198 aa)
Your Current Organism:
Prochlorococcus marinus MIT9303
NCBI taxonomy Id: 59922
Other names: P. marinus str. MIT 9303, Prochlorococcus marinus str. MIT 9303, Prochlorococcus sp. MIT 9303, Prochlorococcus sp. MIT9303
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