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| | hemD | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (277 aa) |
| | ABM79361.1 | O-acetylserine (thiol)-lyase A; COG31 Cysteine synthase [Amino acid transport and metabolism]; Belongs to the cysteine synthase/cystathionine beta- synthase family. (328 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (448 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (326 aa) |
| | fabD | COG331 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]. (298 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (421 aa) |
| | ABM79460.1 | Predicted thioesterase; Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis; Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily. (151 aa) |
| | menC | Putative O-succinylbenzoate synthase; COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (322 aa) |
| | menA | 1,4-dihydroxy-2-naphthoate (DHNA) octaprenyltransferase; Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone; Belongs to the MenA family. Type 2 subfamily. (324 aa) |
| | argJ | ArgJ family protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (427 aa) |
| | dadA | Putative thiamine biosynthesis oxidoreductase; COG665 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]. (371 aa) |
| | ubiC | COG3161 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]. (178 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (222 aa) |
| | nrdG | Possible organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (226 aa) |
| | queC | Hypothetical ATPase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (229 aa) |
| | pabC | Aminotransferases class-IV; COG115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]. (286 aa) |
| | ABM79713.1 | Possible DNA mismatch repair proteins; mutS. (258 aa) |
| | ABM79721.1 | COG547 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]. (368 aa) |
| | aroG | DAHP synthetase class I; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (360 aa) |
| | aroE | Shikimate / quinate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (322 aa) |
| | thrC | Threonine synthase: Pyridoxal-5'-phosphate-dependent enzymes, beta family protein; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa) |
| | argG | COG137 Argininosuccinate synthase [Amino acid transport and metabolism]; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa) |
| | queG | Uncharacterized Fe-S protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (324 aa) |
| | argH | Fumarate lyase:Delta crystallin; COG165 Argininosuccinate lyase [Amino acid transport and metabolism]. (470 aa) |
| | thiL | Putative thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (327 aa) |
| | accB | Biotin / Lipoyl attachment:Acetyl-CoA biotin carboxyl carrier subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (164 aa) |
| | pdxA | Putative pyridoxal phosphate biosynthetic protein PdxA; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (343 aa) |
| | dhsS | Soluble hydrogenase small subunit; COG75 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]. (382 aa) |
| | cbiD | CbiD protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (386 aa) |
| | thiG | Thiamin biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (306 aa) |
| | asd | Aspartate Semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (343 aa) |
| | dapA | Dihydrodipicolinate synthetase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (302 aa) |
| | lysC | COG527 Aspartokinases [Amino acid transport and metabolism]. (595 aa) |
| | cobH | Putative Precorrin-8X methylmutase CobH; COG2082 Precorrin isomerase [Coenzyme metabolism]. (211 aa) |
| | ribH | Putative 6,7-dimethyl-8-ribityllumazine synthase or riboflavin synthase beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (165 aa) |
| | ABM76857.1 | Hypothetical protein; COG535 Predicted Fe-S oxidoreductases [General function prediction only]. (373 aa) |
| | ABM76861.1 | Hypothetical protein; COG535 Predicted Fe-S oxidoreductases [General function prediction only]. (387 aa) |
| | hisH | Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF; Belongs to the HisA/HisF family. (500 aa) |
| | ABM76866.1 | Hypothetical protein; COG663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]. (198 aa) |
| | ABM76869.1 | Hypothetical protein; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]. (260 aa) |
| | ABM76898.1 | COG337 3-dehydroquinate synthetase [Amino acid transport and metabolism]. (372 aa) |
| | ABM76899.1 | COG28 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Belongs to the TPP enzyme family. (575 aa) |
| | cysE | COG1045 Serine acetyltransferase [Amino acid transport and metabolism]. (247 aa) |
| | ABM76944.1 | COG1262 Uncharacterized conserved protein [Function unknown]. (393 aa) |
| | ABM76950.1 | Zinc metallopeptidase M20/M25/M40 family protein; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]. (398 aa) |
| | thiC | ThiC family protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (459 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (192 aa) |
| | ABM76961.1 | COG720 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]. (306 aa) |
| | ABM76962.1 | RibD/ribG C-terminal domain; COG1985 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]. (238 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa) |
| | ABM77091.1 | Hypothetical protein. (149 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (442 aa) |
| | bioA | Putative diaminopelargonic acid synthase; COG161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (442 aa) |
| | bioD | Putative Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (232 aa) |
| | queF | GTP cyclohydrolase I-like protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (135 aa) |
| | serA | Putative D-3-phosphoglycerate dehydrogenase (PGDH); COG111 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa) |
| | purC | SAICAR synthetase; COG152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase [Nucleotide transport and metabolism]; Belongs to the SAICAR synthetase family. (242 aa) |
| | fabZ | Putative (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (135 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | aroH | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (128 aa) |
| | cobT | COG2038 NaMN:DMB phosphoribosyltransferase [Coenzyme metabolism]; Belongs to the UPF0284 family. (425 aa) |
| | ribE | COG307 Riboflavin synthase alpha chain [Coenzyme metabolism]. (220 aa) |
| | ABM77404.1 | 3-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (262 aa) |
| | ubiA | Probable 4-hydroxybenzoate-octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of plastoquinone-9 (PQ-9) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 4-hydroxy-3-solanesylbenzoate. Belongs to the UbiA prenyltransferase family. (297 aa) |
| | cobM | Putative precorrin-4 C11-methyltransferase; COG2875 Precorrin-4 methylase [Coenzyme metabolism]; Belongs to the precorrin methyltransferase family. (251 aa) |
| | ABM77463.1 | COG523 Putative GTPases (G3E family) [General function prediction only]. (366 aa) |
| | ABM77464.1 | 4a-hydroxytetrahydrobiopterin dehydratase (PCD); COG2154 Pterin-4a-carbinolamine dehydratase [Coenzyme metabolism]. (96 aa) |
| | argB | Aspartokinase superfamily:Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (308 aa) |
| | cobK | COG2099 Precorrin-6x reductase [Coenzyme metabolism]. (273 aa) |
| | cobO | Possible cob(I)alamin adenosyltransferase; COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]. (230 aa) |
| | ABM77529.1 | Creatininase; COG1402 Uncharacterized protein, putative amidase [General function prediction only]. (273 aa) |
| | ABM77531.1 | Hypothetical protein. (145 aa) |
| | ABM77532.1 | Hypothetical protein. (191 aa) |
| | accA | acetyl-CoA carboxylase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (329 aa) |
| | trpF | COG135 Phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Belongs to the TrpF family. (225 aa) |
| | ABM77567.1 | COG2154 Pterin-4a-carbinolamine dehydratase [Coenzyme metabolism]. (83 aa) |
| | hisG | Possible ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (217 aa) |
| | cobQ | Cobyric acid synthase CobB; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (506 aa) |
| | ilvN | COG440 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]. (176 aa) |
| | ABM77619.1 | COG5031 Uncharacterized protein involved in ubiquinone biosynthesis [Coenzyme metabolism]. (219 aa) |
| | thrA | Homoserine dehydrogenase:ACT domain; COG460 Homoserine dehydrogenase [Amino acid transport and metabolism]. (438 aa) |
| | hisH-2 | Glutamine amidotransferase class-I; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (213 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (540 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (302 aa) |
| | ABM77693.1 | Conserved hypothetical protein. (195 aa) |
| | pdxJ | Pyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (245 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (306 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (455 aa) |
| | uppS | Undecaprenyl pyrophosphate synthetase (UPPS); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (265 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (335 aa) |
| | ABM77865.1 | Cobalamin synthesis protein/P47K; COG523 Putative GTPases (G3E family) [General function prediction only]. (457 aa) |
| | ABM77970.1 | COG2138 Uncharacterized conserved protein [Function unknown]. (359 aa) |
| | metA | Putative homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (297 aa) |
| | met17 | COG2873 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]. (442 aa) |
| | ABM78081.1 | COG535 Predicted Fe-S oxidoreductases [General function prediction only]. (332 aa) |
| | carB | COG458 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Belongs to the CarB family. (1102 aa) |
| | tpi | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (243 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (283 aa) |
| | ABM78142.1 | Conserved hypothetical protein. (218 aa) |
| | ubiH | Possible 2-octaprenyl-6-methoxyphenol 4-monoxygenase; COG654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism. (396 aa) |
| | apt | Possible phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (193 aa) |
| | cobU | COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme metabolism]. (186 aa) |
| | metH | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1214 aa) |
| | ilvE | Putative Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa) |
| | cobN | COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]. (1259 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (323 aa) |
| | pgi | Phosphoglucose isomerase (PGI); COG166 Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Belongs to the GPI family. (536 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (371 aa) |
| | ribB | Possible GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (630 aa) |
| | hisZ | Possible Histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (392 aa) |
| | dxs | 1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (644 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (372 aa) |
| | nadA | Quinolinate synthetase A protein; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (333 aa) |
| | trpD | Putative Anthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (370 aa) |
| | carA | COG505 Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Belongs to the CarA family. (379 aa) |
| | gdhA | COG334 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (451 aa) |
| | glnA | Glutamine synthetase, glutamate--ammonia ligase; COG174 Glutamine synthetase [Amino acid transport and metabolism]. (473 aa) |
| | glpX | Fructose-1,6-bisphosphatase/sedoheptulose-1, 7-bis phosphatase; Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6- phosphate and sedoheptulose 7-phosphate, respectively; Belongs to the FBPase class 2 family. (334 aa) |
| | ilvD | COG129 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Belongs to the IlvD/Edd family. (556 aa) |
| | cobW | Putative cobalamin synthesis protein; COG523 Putative GTPases (G3E family) [General function prediction only]. (381 aa) |
| | accD | acetyl-CoA carboxylase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (293 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (357 aa) |
| | proB | Putative glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (361 aa) |
| | hisA | COG106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]. (255 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (278 aa) |
| | hisI | COG139 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; In the N-terminal section; belongs to the PRA-CH family. (222 aa) |
| | ABM78573.1 | COG720 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]. (161 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (438 aa) |
| | thrB | Homoserine kinase:GHMP kinases putative ATP-binding domain; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (316 aa) |
| | menD | Probable 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). (608 aa) |
| | menB | Napthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). (297 aa) |
| | aroA | EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (441 aa) |
| | ubiD | COG43 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Belongs to the UbiD family. (521 aa) |
| | comB | Probable 2-phosphosulfolactate phosphatase; COG2045 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Belongs to the ComB family. (243 aa) |
| | ABM78665.1 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (368 aa) |
| | cobL | Putative precorrin-6y methylase; COG2242 Precorrin-6B methylase 2 [Coenzyme metabolism]. (431 aa) |
| | ribF | Putative riboflavin kinase/FAD synthase; COG196 FAD synthase [Coenzyme metabolism]; Belongs to the ribF family. (310 aa) |
| | thiE | Thiamine monophosphate synthase (TMP); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (353 aa) |
| | thiS | DUF170; COG2104 Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]. (70 aa) |
| | trpC | COG134 Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Belongs to the TrpC family. (301 aa) |
| | argD | COG4992 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (418 aa) |
| | panB | Putative Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (272 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa) |
| | cbiB | Putative cobalamin biosynthetic protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (302 aa) |
| | ABM78756.1 | Hypothetical protein. (376 aa) |
| | hisH-3 | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (218 aa) |
| | ABM78758.1 | Hypothetical protein; COG107 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Belongs to the HisA/HisF family. (266 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of 2-phytyl- 1,4-beta-naphthoquinol to phylloquinol. (233 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF (cyclase); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | ABM78814.1 | COG5031 Uncharacterized protein involved in ubiquinone biosynthesis [Coenzyme metabolism]. (222 aa) |
| | ABM78836.1 | Possible Galanin. (329 aa) |
| | ABM78855.1 | O-acetylserine (thiol)-lyase A; COG31 Cysteine synthase [Amino acid transport and metabolism]; Belongs to the cysteine synthase/cystathionine beta- synthase family. (328 aa) |
| | queA | Queuosine biosynthesis protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (371 aa) |
| | proC | Delta 1-pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (280 aa) |
| | cobI | COG2243 Precorrin-2 methylase [Coenzyme metabolism]; Belongs to the precorrin methyltransferase family. (254 aa) |
| | mtnD | Methionine salvage pathway enzyme E-2/E-2'-like protein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (218 aa) |
| | aroQ | Dehydroquinase class II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (164 aa) |
| | mtnB | Putative sugar aldolase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (207 aa) |
| | mtnC | Putative enolase-phosphatase E-1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (240 aa) |
| | ABM78942.1 | Conserved hypothetical protein; COG824 Predicted thioesterase [General function prediction only]. (151 aa) |
| | panC | Panthothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. (488 aa) |
| | ABM79023.1 | COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]. (402 aa) |
| | tyrA | Prephenate dehydrogenase. (314 aa) |
| | alr | Putative Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (398 aa) |
| | cobJ | Bifunctional cbiH protein and precorrin-3B C17-methyltransferase; COG1010 Precorrin-3B methylase [Coenzyme metabolism]. (594 aa) |
| | lipA-2 | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (294 aa) |
| | gltB | Ferredoxin-dependent glutamate synthase, Fd-GOGAT; COG69 Glutamate synthase domain 2 [Amino acid transport and metabolism]. (1527 aa) |
| | pheA | Chorismate mutase-Prephenate dehydratase; COG77 Prephenate dehydratase [Amino acid transport and metabolism]. (304 aa) |
| | dapL | Putative aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (417 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (362 aa) |
| | ABM79161.1 | Creatininase; COG1402 Uncharacterized protein, putative amidase [General function prediction only]. (262 aa) |
| | ABM79185.1 | COG2109 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]. (204 aa) |
| | leuD | COG66 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Belongs to the LeuD family. (210 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (478 aa) |
| | glyA | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa) |
| | cobS | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (260 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (372 aa) |
| | hisB | COG131 Imidazoleglycerol-phosphate dehydratase [Amino acid transport and metabolism]. (209 aa) |
| | fabI | COG623 Enoyl-[acyl-carrier-protein]. (268 aa) |
| | folK | Possible 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; COG801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism]. (248 aa) |
| | mtnP | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (304 aa) |
| | mtnA | Initiation factor 2 subunit family protein; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (370 aa) |
| | ugd | COG1004 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]. (482 aa) |
| | kdsA | COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Belongs to the KdsA family. (300 aa) |
| | acpP | Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. (103 aa) |
| | fabF | 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (415 aa) |
