node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABM79074.1 | eno | P9303_23391 | P9303_27721 | Hypothetical protein; COG3588 Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.900 |
ABM79074.1 | glpX | P9303_23391 | P9303_16831 | Hypothetical protein; COG3588 Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]. | Fructose-1,6-bisphosphatase/sedoheptulose-1, 7-bis phosphatase; Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6- phosphate and sedoheptulose 7-phosphate, respectively; Belongs to the FBPase class 2 family. | 0.911 |
ABM79074.1 | gpmI | P9303_23391 | P9303_05081 | Hypothetical protein; COG3588 Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]. | Phosphoglycerate mutase, co-factor-independent (iPGM); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | 0.833 |
eno | ABM79074.1 | P9303_27721 | P9303_23391 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | Hypothetical protein; COG3588 Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]. | 0.900 |
eno | glyA | P9303_27721 | P9303_24721 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.508 |
eno | gpmI | P9303_27721 | P9303_05081 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | Phosphoglycerate mutase, co-factor-independent (iPGM); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | 0.990 |
eno | ppc | P9303_27721 | P9303_22741 | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. | 0.937 |
glpX | ABM79074.1 | P9303_16831 | P9303_23391 | Fructose-1,6-bisphosphatase/sedoheptulose-1, 7-bis phosphatase; Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6- phosphate and sedoheptulose 7-phosphate, respectively; Belongs to the FBPase class 2 family. | Hypothetical protein; COG3588 Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]. | 0.911 |
glpX | gpmI | P9303_16831 | P9303_05081 | Fructose-1,6-bisphosphatase/sedoheptulose-1, 7-bis phosphatase; Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6- phosphate and sedoheptulose 7-phosphate, respectively; Belongs to the FBPase class 2 family. | Phosphoglycerate mutase, co-factor-independent (iPGM); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | 0.463 |
glyA | eno | P9303_24721 | P9303_27721 | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.508 |
glyA | gpmB | P9303_24721 | P9303_07531 | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Possible alpha-ribazole-5'-P phosphatase; COG406 Fructose-2,6-bisphosphatase [Carbohydrate transport and metabolism]; Belongs to the phosphoglycerate mutase family. | 0.913 |
glyA | ppc | P9303_24721 | P9303_22741 | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. | 0.475 |
glyA | serA | P9303_24721 | P9303_05241 | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative D-3-phosphoglycerate dehydrogenase (PGDH); COG111 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.537 |
glyA | spt | P9303_24721 | P9303_16451 | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | COG75 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]. | 0.919 |
gpmB | glyA | P9303_07531 | P9303_24721 | Possible alpha-ribazole-5'-P phosphatase; COG406 Fructose-2,6-bisphosphatase [Carbohydrate transport and metabolism]; Belongs to the phosphoglycerate mutase family. | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.913 |
gpmB | spt | P9303_07531 | P9303_16451 | Possible alpha-ribazole-5'-P phosphatase; COG406 Fructose-2,6-bisphosphatase [Carbohydrate transport and metabolism]; Belongs to the phosphoglycerate mutase family. | COG75 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]. | 0.901 |
gpmI | ABM79074.1 | P9303_05081 | P9303_23391 | Phosphoglycerate mutase, co-factor-independent (iPGM); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | Hypothetical protein; COG3588 Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]. | 0.833 |
gpmI | eno | P9303_05081 | P9303_27721 | Phosphoglycerate mutase, co-factor-independent (iPGM); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.990 |
gpmI | glpX | P9303_05081 | P9303_16831 | Phosphoglycerate mutase, co-factor-independent (iPGM); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | Fructose-1,6-bisphosphatase/sedoheptulose-1, 7-bis phosphatase; Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6- phosphate and sedoheptulose 7-phosphate, respectively; Belongs to the FBPase class 2 family. | 0.463 |
gpmI | ppc | P9303_05081 | P9303_22741 | Phosphoglycerate mutase, co-factor-independent (iPGM); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. | 0.834 |