(149 nodes) Spliceosome network (Penicillium polonicum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	A0A1V6N6C0	Uncharacterized protein; Belongs to the heat shock protein 70 family. (615 aa)
	A0A1V6N6E0	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (187 aa)
	A0A1V6N6M7	PPIase cyclophilin-type domain-containing protein. (544 aa)
	A0A1V6N6M8	Uncharacterized protein. (686 aa)
	A0A1V6N6R6	Tr-type G domain-containing protein. (983 aa)
	A0A1V6N6Y4	Uncharacterized protein. (581 aa)
	A0A1V6N7F5	Uncharacterized protein. (822 aa)
	A0A1V6N7T4	Uncharacterized protein. (358 aa)
	A0A1V6N7U7	Uncharacterized protein. (1063 aa)
	A0A1V6N844	Uncharacterized protein. (1231 aa)
	A0A1V6N845	U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (98 aa)
	A0A1V6N847	Uncharacterized protein. (1272 aa)
	A0A1V6N8V8	Uncharacterized protein. (882 aa)
	A0A1V6N928	Uncharacterized protein. (588 aa)
	A0A1V6N959	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (127 aa)
	A0A1V6N961	CPSF_A domain-containing protein. (1209 aa)
	A0A1V6N9R0	Uncharacterized protein. (186 aa)
	A0A1V6N9R3	Uncharacterized protein. (182 aa)
	A0A1V6NAF3	Uncharacterized protein. (1014 aa)
	A0A1V6NAN6	SNRNP27 domain-containing protein. (232 aa)
	A0A1V6NAR1	RRM domain-containing protein. (152 aa)
	A0A1V6NB39	Tudor domain-containing protein. (286 aa)
	A0A1V6NB81	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1083 aa)
	A0A1V6NBA0	Uncharacterized protein. (559 aa)
	A0A1V6NBH6	GH16 domain-containing protein. (353 aa)
	A0A1V6NBU4	Uncharacterized protein. (637 aa)
	A0A1V6NBW1	Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family. (125 aa)
	A0A1V6NC13	Uncharacterized protein. (108 aa)
	A0A1V6NC32	RanBP2-type domain-containing protein. (311 aa)
	A0A1V6NCL5	Uncharacterized protein. (627 aa)
	A0A1V6NCN7	DUF1716 domain-containing protein. (583 aa)
	A0A1V6NCS1	Uncharacterized protein. (261 aa)
	A0A1V6ND10	Uncharacterized protein; Belongs to the DEAD box helicase family. (496 aa)
	A0A1V6ND18	Uncharacterized protein. (760 aa)
	A0A1V6ND42	Uncharacterized protein. (247 aa)
	A0A1V6NDE3	WD_REPEATS_REGION domain-containing protein. (357 aa)
	A0A1V6NDH0	Uncharacterized protein. (705 aa)
	A0A1V6NDH3	RRM domain-containing protein. (136 aa)
	A0A1V6NDM9	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1053 aa)
	A0A1V6NDV6	Nop domain-containing protein. (519 aa)
	A0A1V6NDY0	Uncharacterized protein. (1162 aa)
	A0A1V6NDY7	CVNH domain-containing protein. (109 aa)
	A0A1V6NE99	Uncharacterized protein. (672 aa)
	A0A1V6NEU0	Uncharacterized protein. (721 aa)
	A0A1V6NEU1	Uncharacterized protein. (200 aa)
	A0A1V6NEW8	Uncharacterized protein. (462 aa)
	LSM8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (98 aa)
	A0A1V6NFV2	PNP_UDP_1 domain-containing protein. (830 aa)
	A0A1V6NGG2	Small nuclear ribonucleoprotein Sm D2. (120 aa)
	A0A1V6NGI9	Uncharacterized protein. (795 aa)
	A0A1V6NGX3	Uncharacterized protein. (442 aa)
	A0A1V6NH53	Uncharacterized protein. (475 aa)
	A0A1V6NH61	WD_REPEATS_REGION domain-containing protein. (452 aa)
	A0A1V6NHB8	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (162 aa)
	A0A1V6NHL5	TPR_REGION domain-containing protein. (844 aa)
	A0A1V6NHX3	Uncharacterized protein. (249 aa)
	A0A1V6NIB2	Uncharacterized protein. (809 aa)
	A0A1V6NIE7	Uncharacterized protein. (756 aa)
	A0A1V6NIR2	BTB domain-containing protein. (258 aa)
	A0A1V6NIR7	CPSF_A domain-containing protein. (1262 aa)
	A0A1V6NIY1	Pre-mRNA-splicing factor; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. (1395 aa)
	A0A1V6NJF5	Uncharacterized protein. (695 aa)
	A0A1V6NJK1	Sm domain-containing protein. (211 aa)
	A0A1V6NJT1	F-box domain-containing protein. (605 aa)
	A0A1V6NJV0	Uncharacterized protein. (929 aa)
	A0A1V6NKI8	Uncharacterized protein. (987 aa)
	A0A1V6NKK2	RRM domain-containing protein. (113 aa)
	A0A1V6NKT1	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (623 aa)
	A0A1V6NL69	APH domain-containing protein. (286 aa)
	A0A1V6NLC2	Uncharacterized protein. (790 aa)
	A0A1V6NLC5	Matrin-type domain-containing protein. (235 aa)
	A0A1V6NLL3	Uncharacterized protein. (445 aa)
	A0A1V6NLQ2	ArAE_2 domain-containing protein. (1040 aa)
	A0A1V6NLU1	Uncharacterized protein; Belongs to the heat shock protein 70 family. (636 aa)
	A0A1V6NLY3	Uncharacterized protein. (183 aa)
	A0A1V6NMZ1	Uncharacterized protein. (670 aa)
	A0A1V6NMZ2	Uncharacterized protein. (224 aa)
	A0A1V6NN37	Uncharacterized protein. (599 aa)
	A0A1V6NN58	PSP domain-containing protein. (561 aa)
	A0A1V6NN79	Uncharacterized protein. (1010 aa)
	A0A1V6NN87	Uncharacterized protein. (250 aa)
	A0A1V6NNA4	Uncharacterized protein. (301 aa)
	A0A1V6NNK9	Small nuclear ribonucleoprotein Sm D3. (117 aa)
	A0A1V6NNQ9	Sm domain-containing protein. (125 aa)
	A0A1V6NNX3	Uncharacterized protein. (255 aa)
	A0A1V6NP26	RRM domain-containing protein. (188 aa)
	A0A1V6NP57	RRM domain-containing protein. (158 aa)
	A0A1V6NP61	Sm domain-containing protein. (103 aa)
	A0A1V6NPL9	Uncharacterized protein. (214 aa)
	A0A1V6NPR4	Zn(2)-C6 fungal-type domain-containing protein. (698 aa)
	A0A1V6NPY6	Uncharacterized protein. (579 aa)
	A0A1V6NPZ8	C2H2-type domain-containing protein. (206 aa)
	A0A1V6NQA1	Sm domain-containing protein. (80 aa)
	A0A1V6NQA7	WD_REPEATS_REGION domain-containing protein. (583 aa)
	A0A1V6NQF3	JAB_MPN domain-containing protein. (2355 aa)
	A0A1V6NQF6	Uncharacterized protein; Belongs to the DEAD box helicase family. (793 aa)
	A0A1V6NQP1	Zn(2)-C6 fungal-type domain-containing protein. (982 aa)
	A0A1V6NQT4	C2H2-type domain-containing protein. (213 aa)
	A0A1V6NR51	Uncharacterized protein. (2349 aa)
	A0A1V6NRS2	Uncharacterized protein; Belongs to the DEAD box helicase family. (563 aa)
	A0A1V6NS37	Uncharacterized protein. (606 aa)
	A0A1V6NSC5	Uncharacterized protein. (762 aa)
	A0A1V6NT20	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (87 aa)
	A0A1V6NTF1	Uncharacterized protein. (367 aa)
	A0A1V6NTF5	Uncharacterized protein. (148 aa)
	A0A1V6NTH9	G-patch domain-containing protein. (530 aa)
	A0A1V6NU26	Uncharacterized protein. (660 aa)
	A0A1V6NU78	Uncharacterized protein. (249 aa)
	A0A1V6NU82	G-patch domain-containing protein. (535 aa)
	A0A1V6NUD7	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (126 aa)
	A0A1V6NUE1	Uncharacterized protein. (819 aa)
	A0A1V6NW43	Uncharacterized protein. (552 aa)
	A0A1V6NWV3	Uncharacterized protein. (588 aa)
	A0A1V6NWY2	RRM domain-containing protein. (236 aa)
	A0A1V6NX46	Uncharacterized protein. (218 aa)
	A0A1V6NX48	WD_REPEATS_REGION domain-containing protein. (520 aa)
	A0A1V6NXZ4	RRM domain-containing protein. (184 aa)
	A0A1V6NYC7	Slu7 domain-containing protein. (470 aa)
	A0A1V6NYD0	Small nuclear ribonucleoprotein G. (78 aa)
	A0A1V6NYR6	Uncharacterized protein. (487 aa)
	A0A1V6NYZ3	RRM domain-containing protein. (98 aa)
	A0A1V6NZ28	Uncharacterized protein. (519 aa)
	A0A1V6NZ36	Uncharacterized protein. (2204 aa)
	A0A1V6NZ93	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1065 aa)
	A0A1V6P188	RRM domain-containing protein. (240 aa)
	A0A1V6P1B2	Phosducin domain-containing protein. (236 aa)
	A0A1V6P1T3	Uncharacterized protein; Belongs to the complex I LYR family. (115 aa)
	A0A1V6P1V9	Uncharacterized protein. (217 aa)
	A0A1V6P1Y6	Uncharacterized protein. (248 aa)
	A0A1V6P210	ACT_7 domain-containing protein. (485 aa)
	A0A1V6P267	RRM domain-containing protein. (383 aa)
	A0A1V6P2B5	Uncharacterized protein. (521 aa)
	A0A1V6P2J3	Matrin-type domain-containing protein. (503 aa)
	A0A1V6P2X3	SF3b1 domain-containing protein. (1208 aa)
	A0A1V6P305	Uncharacterized protein; Belongs to the DEAD box helicase family. (399 aa)
	A0A1V6P308	RRM domain-containing protein. (472 aa)
	A0A1V6P353	Uncharacterized protein. (486 aa)
	A0A1V6P3J2	Uncharacterized protein. (159 aa)
	A0A1V6P3U6	Uncharacterized protein; Belongs to the heat shock protein 70 family. (566 aa)
	A0A1V6P4R5	SKIP_SNW domain-containing protein. (580 aa)
	A0A1V6P4X0	Uncharacterized protein. (191 aa)
	A0A1V6P556	CID domain-containing protein. (516 aa)
	A0A1V6P5A2	Uncharacterized protein. (474 aa)
	A0A1V6P5C1	Uncharacterized protein. (566 aa)
	LSM5	U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (83 aa)
	A0A1V6P5X4	Nuclear cap-binding protein subunit 2. (178 aa)
	A0A1V6P6K9	Uncharacterized protein. (237 aa)
	A0A1V6P6U9	Spliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family. (143 aa)
	A0A1V6P6W9	CVNH domain-containing protein. (124 aa)

Your Current Organism:

Penicillium polonicum

NCBI taxonomy Id: 60169
Other names: CBS 222.28, IBT 12821, IMI 291194, MUCL 29204, NRRL 995, P. polonicum, Penicillium aurantiogriseum var. polonicum, Penicillium aurantiogriseum var. polonicum (W.Zalessky) Frisvad & Filt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1V6N6C0	A0A1V6N6E0	A0A1V6N6C0	A0A1V6N6E0	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.414
A0A1V6N6C0	A0A1V6N6M7	A0A1V6N6C0	A0A1V6N6M7	Uncharacterized protein; Belongs to the heat shock protein 70 family.	PPIase cyclophilin-type domain-containing protein.	0.406
A0A1V6N6C0	A0A1V6N959	A0A1V6N6C0	A0A1V6N959	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.440
A0A1V6N6C0	A0A1V6NAR1	A0A1V6N6C0	A0A1V6NAR1	Uncharacterized protein; Belongs to the heat shock protein 70 family.	RRM domain-containing protein.	0.688
A0A1V6N6C0	A0A1V6NCN7	A0A1V6N6C0	A0A1V6NCN7	Uncharacterized protein; Belongs to the heat shock protein 70 family.	DUF1716 domain-containing protein.	0.676
A0A1V6N6C0	A0A1V6ND42	A0A1V6N6C0	A0A1V6ND42	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein.	0.498
A0A1V6N6C0	A0A1V6NDH3	A0A1V6N6C0	A0A1V6NDH3	Uncharacterized protein; Belongs to the heat shock protein 70 family.	RRM domain-containing protein.	0.540
A0A1V6N6C0	A0A1V6NH61	A0A1V6N6C0	A0A1V6NH61	Uncharacterized protein; Belongs to the heat shock protein 70 family.	WD_REPEATS_REGION domain-containing protein.	0.625
A0A1V6N6C0	A0A1V6NHB8	A0A1V6N6C0	A0A1V6NHB8	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.406
A0A1V6N6C0	A0A1V6NLC2	A0A1V6N6C0	A0A1V6NLC2	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein.	0.794
A0A1V6N6C0	A0A1V6NLU1	A0A1V6N6C0	A0A1V6NLU1	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.930
A0A1V6N6C0	A0A1V6NNX3	A0A1V6N6C0	A0A1V6NNX3	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein.	0.683
A0A1V6N6C0	A0A1V6NUD7	A0A1V6N6C0	A0A1V6NUD7	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.440
A0A1V6N6C0	A0A1V6NXZ4	A0A1V6N6C0	A0A1V6NXZ4	Uncharacterized protein; Belongs to the heat shock protein 70 family.	RRM domain-containing protein.	0.540
A0A1V6N6C0	A0A1V6NYZ3	A0A1V6N6C0	A0A1V6NYZ3	Uncharacterized protein; Belongs to the heat shock protein 70 family.	RRM domain-containing protein.	0.540
A0A1V6N6C0	A0A1V6P3U6	A0A1V6N6C0	A0A1V6P3U6	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.800
A0A1V6N6C0	A0A1V6P5A2	A0A1V6N6C0	A0A1V6P5A2	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein.	0.719
A0A1V6N6C0	A0A1V6P6K9	A0A1V6N6C0	A0A1V6P6K9	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein.	0.719
A0A1V6N6E0	A0A1V6N6C0	A0A1V6N6E0	A0A1V6N6C0	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.414
A0A1V6N6E0	A0A1V6N6M8	A0A1V6N6E0	A0A1V6N6M8	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	Uncharacterized protein.	0.406

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