STRINGSTRING
NUMBL NUMBL LTBP4 LTBP4 PARD6A PARD6A SMURF2 SMURF2 BMPR1B BMPR1B WWP2 WWP2 TEAD1 TEAD1 LLGL2 LLGL2 MOB1B MOB1B INHBE INHBE INHBC INHBC LNX1 LNX1 FSHB FSHB GDF11 GDF11 TOX3 TOX3 AMHR2 AMHR2 ACVR1B ACVR1B ACVRL1 ACVRL1 ANKRD33 ANKRD33 ZP1 ZP1 UBE3A UBE3A ARHGAP17 ARHGAP17 SCNN1B SCNN1B SCNN1G SCNN1G PTEN PTEN NOBOX NOBOX BMP6 BMP6 LTBP3 LTBP3 INHA INHA FBN3 FBN3 GDF7 GDF7 LLGL1 LLGL1 AMOT AMOT DLG1 DLG1 ARHGEF18 ARHGEF18 SCRIB SCRIB TSC22D3 TSC22D3 MPDZ MPDZ ZP4 ZP4 CRB3 CRB3 NF2 NF2 TGFBR2 TGFBR2 BMPR1A BMPR1A VGLL4 VGLL4 NRBP1 NRBP1 TEAD3 TEAD3 GDF2 GDF2 PARD3B PARD3B GDF5 GDF5 ARRDC5 ARRDC5 BMPR2 BMPR2 FSD1 FSD1 SCNN1A SCNN1A AMOTL2 AMOTL2 RASSF4 RASSF4 TGFBR1 TGFBR1 TEAD4 TEAD4 PARD3 PARD3 WWTR1 WWTR1 TSC22D2 TSC22D2 EPB41L4B EPB41L4B LTBP1 LTBP1 TSHR TSHR AMH AMH NEDD4 NEDD4 TGFB3 TGFB3 ITCH ITCH MSTN MSTN STK3 STK3 NDFIP1 NDFIP1 GDF6 GDF6 PRKCI PRKCI SKIL SKIL NUMB NUMB BMP15 BMP15 FSTL3 FSTL3 WWP1 WWP1 SMAD6 SMAD6 BMP5 BMP5 SMAD3 SMAD3 SMAD5 SMAD5 MPP5 MPP5 RASSF2 RASSF2 CRB2 CRB2 BMP2 BMP2 CRB1 CRB1 LHCGR LHCGR GDF9 GDF9 FSHR FSHR CHRD CHRD ENG ENG SGK2 SGK2 SGK3 SGK3 RASSF1 RASSF1 STK4 STK4 CHI3L1 CHI3L1 ACVR2B ACVR2B PLEKHA6-2 PLEKHA6-2 BMP4 BMP4 RASSF5 RASSF5 BMP10 BMP10 SAV1 SAV1 ZFYVE16 ZFYVE16 FIGLA FIGLA PARD6B PARD6B INHBA INHBA BMP7 BMP7 SOHLH1 SOHLH1 TGFB2 TGFB2 VGLL2 VGLL2 ACVR1 ACVR1 ACVR1C ACVR1C ACVR2A ACVR2A FST FST INHBB INHBB SGK1 SGK1 LATS1 LATS1 FSD2 FSD2 CGA CGA NDFIP2 NDFIP2 ZBTB14 ZBTB14 SMURF1 SMURF1 TSC22D1 TSC22D1 SMAD9 SMAD9 SOHLH2 SOHLH2 LNX2 LNX2 SMAD2 SMAD2 SMAD7 SMAD7 SMAD4 SMAD4 ZP3 ZP3 LATS2 LATS2 NEDD4L NEDD4L PARD6G PARD6G TGFB1 TGFB1 SMAD1 SMAD1 AMOTL1 AMOTL1 YAP1 YAP1 PLEKHA4 PLEKHA4 LHB LHB TEAD2 TEAD2 DTX1 DTX1 TSHB TSHB TGFBR3 TGFBR3 PATJ PATJ ZFYVE9 ZFYVE9 ENSCSAP00000016878 ENSCSAP00000016878 NBL1 NBL1 SKI SKI PRKCZ PRKCZ SCNN1D SCNN1D NOG NOG FOXL2 FOXL2 GREM2 GREM2 GREM1 GREM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NUMBLNUMB like endocytic adaptor protein. (602 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1557 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
SMURF2SMAD specific E3 ubiquitin protein ligase 2. (474 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (536 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
TEAD1TEA domain transcription factor 1. (436 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1020 aa)
MOB1BMOB kinase activator 1B. (221 aa)
INHBEInhibin subunit beta E. (351 aa)
INHBCInhibin subunit beta C. (352 aa)
LNX1Ligand of numb-protein X 1. (631 aa)
FSHBFollicle stimulating hormone subunit beta. (129 aa)
GDF11Growth differentiation factor 11. (406 aa)
TOX3TOX high mobility group box family member 3. (572 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (573 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ANKRD33Ankyrin repeat domain 33. (452 aa)
ZP1Zona pellucida glycoprotein 1. (641 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (872 aa)
ARHGAP17Rho GTPase activating protein 17. (763 aa)
SCNN1BSodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (640 aa)
SCNN1GSodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (649 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NOBOXNOBOX oogenesis homeobox. (691 aa)
BMP6Bone morphogenetic protein 6. (433 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1298 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
FBN3Fibrillin 3. (2776 aa)
GDF7Growth differentiation factor 7. (447 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1064 aa)
AMOTAngiomotin. (1100 aa)
DLG1Uncharacterized protein; Belongs to the MAGUK family. (800 aa)
ARHGEF18Uncharacterized protein. (1172 aa)
SCRIBScribble planar cell polarity protein. (1678 aa)
TSC22D3Uncharacterized protein. (134 aa)
MPDZMultiple PDZ domain crumbs cell polarity complex component. (2089 aa)
ZP4Zona pellucida glycoprotein 4. (542 aa)
CRB3Crumbs cell polarity complex component 3. (125 aa)
NF2Neurofibromin 2. (590 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
VGLL4Vestigial like family member 4. (296 aa)
NRBP1Nuclear receptor binding protein 1. (535 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (370 aa)
GDF2Growth differentiation factor 2. (429 aa)
PARD3BPar-3 family cell polarity regulator beta. (1037 aa)
GDF5Growth differentiation factor 5. (499 aa)
ARRDC5Arrestin domain containing 5. (346 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
FSD1Fibronectin type III and SPRY domain containing 1. (496 aa)
SCNN1ASodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (669 aa)
AMOTL2Angiomotin like 2. (782 aa)
RASSF4Ras association domain family member 4. (321 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
TEAD4TEA domain transcription factor 4. (361 aa)
PARD3Par-3 family cell polarity regulator. (1218 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
TSC22D2TSC22 domain family member 2. (780 aa)
EPB41L4BErythrocyte membrane protein band 4.1 like 4B. (902 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1724 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (708 aa)
AMHAnti-Mullerian hormone. (566 aa)
NEDD4E3 ubiquitin-protein ligase. (900 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
MSTNMyostatin. (375 aa)
STK3Serine/threonine kinase 3. (491 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
GDF6Growth differentiation factor 6. (455 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. (482 aa)
SKILSKI like proto-oncogene. (684 aa)
NUMBNUMB endocytic adaptor protein. (652 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
FSTL3Follistatin like 3. (263 aa)
WWP1WW domain containing E3 ubiquitin protein ligase 1. (684 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
RASSF2Ras association domain family member 2. (328 aa)
CRB2Crumbs cell polarity complex component 2. (1287 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
CRB1Crumbs cell polarity complex component 1. (1335 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (701 aa)
GDF9Growth differentiation factor 9. (455 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (669 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (956 aa)
ENGEndoglin. (658 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
RASSF1Ras association domain family member 1. (345 aa)
STK4Serine/threonine kinase 4. (487 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (383 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (354 aa)
PLEKHA6-2WW domain-containing protein. (89 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
RASSF5Ras association domain family member 5. (265 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
SAV1Salvador family WW domain containing protein 1. (385 aa)
ZFYVE16Zinc finger FYVE-type containing 16. (1540 aa)
FIGLAFolliculogenesis specific bHLH transcription factor. (219 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
INHBAInhibin subunit beta A. (426 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SOHLH1Spermatogenesis and oogenesis specific basic helix-loop-helix 1. (329 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
VGLL2Vestigial like family member 2. (317 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (443 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
FSTFollistatin. (344 aa)
INHBBInhibin subunit beta B. (320 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
LATS1Large tumor suppressor kinase 1. (1130 aa)
FSD2Fibronectin type III and SPRY domain containing 2. (754 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
NDFIP2Nedd4 family interacting protein 2. (337 aa)
ZBTB14Zinc finger and BTB domain containing 14. (449 aa)
SMURF1E3 ubiquitin-protein ligase. (728 aa)
TSC22D1TSC22 domain family member 1. (981 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
SOHLH2BHLH domain-containing protein. (300 aa)
LNX2Ligand of numb-protein X 2. (690 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ZP3ZP domain-containing protein. (424 aa)
LATS2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (483 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (993 aa)
PARD6GPB1 domain-containing protein. (133 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
AMOTL1Angiomotin like 1. (941 aa)
YAP1Yes associated protein 1. (508 aa)
PLEKHA4Pleckstrin homology domain containing A4. (721 aa)
LHBCys_knot domain-containing protein. (141 aa)
TEAD2TEA domain transcription factor 2. (447 aa)
DTX1Deltex E3 ubiquitin ligase 1. (624 aa)
TSHBThyroid stimulating hormone subunit beta. (165 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
PATJPATJ crumbs cell polarity complex component. (1802 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1380 aa)
ENSCSAP00000016878TGF_BETA_2 domain-containing protein. (354 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1. (181 aa)
SKISKI proto-oncogene. (728 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. (488 aa)
SCNN1DSodium channel epithelial 1 delta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (800 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FOXL2Forkhead box L2. (376 aa)
GREM2Gremlin. (168 aa)
GREM1Gremlin. (184 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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