Your Input: | |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (947 aa) |
| | CRADD | Death domain-containing protein. (129 aa) |
| | ENSCSAP00000000069 | CARD domain-containing protein. (115 aa) |
| | TNIP3 | TNFAIP3 interacting protein 3. (330 aa) |
| | HIPK4 | Homeodomain interacting protein kinase 4. (615 aa) |
| | TRADD | TNFRSF1A associated via death domain. (308 aa) |
| | ALPK1 | Alpha kinase 1. (1181 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | ZNF567 | Zinc finger protein 567. (599 aa) |
| | IL18BP | Interleukin 18 binding protein. (194 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa) |
| | IRAK3 | Interleukin 1 receptor associated kinase 3. (596 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | MLKL | Mixed lineage kinase domain like pseudokinase. (470 aa) |
| | CASP7 | Caspase 7; Belongs to the peptidase C14A family. (303 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1036 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (899 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (538 aa) |
| | BIK | BCL2 interacting killer. (159 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (212 aa) |
| | ENSCSAP00000002244 | RBR-type E3 ubiquitin transferase. (333 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (338 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (374 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (460 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (686 aa) |
| | WNK2 | WNK lysine deficient protein kinase 2. (1986 aa) |
| | TRAF4 | TNF receptor-associated factor. (470 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (453 aa) |
| | BMF | Bcl2 modifying factor. (184 aa) |
| | SIRT1 | Sirtuin 1. (743 aa) |
| | TMEM198 | Transmembrane protein 198. (360 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (548 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1198 aa) |
| | UNC93B1 | Unc-93 homolog B1, TLR signaling regulator. (597 aa) |
| | SHARPIN | SHANK associated RH domain interactor. (383 aa) |
| | IL33 | Interleukin 33. (270 aa) |
| | IL1RAP | Interleukin 1 receptor accessory protein. (570 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1035 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (500 aa) |
| | GSDMD | Gasdermin D. (424 aa) |
| | FADD | DED domain-containing protein. (189 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (211 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (626 aa) |
| | MEFV | MEFV innate immuity regulator, pyrin. (566 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | PIDD1 | P53-induced death domain protein 1. (910 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (455 aa) |
| | PLEKHG6 | Pleckstrin homology and RhoGEF domain containing G6. (790 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (496 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (520 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (480 aa) |
| | SIGIRR | Single Ig and TIR domain containing. (410 aa) |
| | NLRP6 | NLR family pyrin domain containing 6. (894 aa) |
| | RNF151 | Ring finger protein 151. (244 aa) |
| | TNIP1 | TNFAIP3 interacting protein 1. (637 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | BCL2L10 | Uncharacterized protein. (193 aa) |
| | CNPY3 | Canopy FGF signaling regulator 3. (277 aa) |
| | NLRC4 | NLR family CARD domain containing 4. (1024 aa) |
| | FOXO4 | Forkhead box O4. (505 aa) |
| | BIRC6 | Baculoviral IAP repeat containing 6. (4880 aa) |
| | FASLG | Fas ligand; Belongs to the tumor necrosis factor family. (282 aa) |
| | NFKBIE | NFKB inhibitor epsilon. (361 aa) |
| | TP53INP1 | Tumor protein p53 inducible nuclear protein 1. (165 aa) |
| | FNDC1 | Fibronectin type III domain containing 1. (1880 aa) |
| | NLRP1 | NLR family pyrin domain containing 1. (1106 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | APPL1 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa) |
| | TNFSF10 | Tumor necrosis factor ligand superfamily member. (281 aa) |
| | RBCK1 | RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa) |
| | IGDCC3 | Immunoglobulin superfamily DCC subclass member 3. (819 aa) |
| | RIPK2 | Receptor interacting serine/threonine kinase 2. (443 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (540 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa) |
| | OPTN | Optineurin. (577 aa) |
| | TRAF1 | TNF receptor-associated factor. (416 aa) |
| | LY96 | Lymphocyte antigen 96. (160 aa) |
| | LOC103227720 | TIR domain-containing protein. (1032 aa) |
| | VCPIP1 | Valosin containing protein interacting protein 1. (1221 aa) |
| | TAB3 | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (234 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa) |
| | REL | REL proto-oncogene, NF-kB subunit. (551 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (953 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa) |
| | MAP3K20 | Protein kinase domain-containing protein. (292 aa) |
| | ENSCSAP00000010823 | Protein kinase domain-containing protein. (169 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) |
| | SPATA2 | Spermatogenesis associated 2. (520 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | BCL2A1 | BCL2 related protein A1. (175 aa) |
| | FOXO3 | Forkhead box O3. (672 aa) |
| | ARIH2 | RBR-type E3 ubiquitin transferase. (493 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (563 aa) |
| | NFKBIA | NFKB inhibitor alpha. (317 aa) |
| | TANK | TRAF family member associated NFKB activator. (425 aa) |
| | NAIP | NLR family apoptosis inhibitory protein. (1232 aa) |
| | CARD9 | Caspase recruitment domain family member 9. (499 aa) |
| | TNIP2 | TNFAIP3 interacting protein 2. (429 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (518 aa) |
| | BCL2L2 | BCL2 like 2. (193 aa) |
| | RNF31 | Uncharacterized protein. (905 aa) |
| | TRAF2 | TNF receptor-associated factor. (449 aa) |
| | TNFRSF10A | TNF receptor superfamily member 10a. (472 aa) |
| | BIRC7 | Baculoviral IAP repeat containing 7. (298 aa) |
| | TNFRSF10B | TNF receptor superfamily member 10b. (416 aa) |
| | IL1RN | Interleukin-1. (177 aa) |
| | IL1F10 | Interleukin 1 family member 10. (152 aa) |
| | IL36RN | Interleukin-1. (155 aa) |
| | IL36B | Interleukin-1. (160 aa) |
| | IL36A | Interleukin-1. (160 aa) |
| | IL36G | Interleukin-1. (170 aa) |
| | IL37 | Interleukin-1. (219 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa) |
| | IL1A | Interleukin-1; Belongs to the IL-1 family. (224 aa) |
| | BCL2L11 | BCL2 like 11. (109 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (790 aa) |
| | IL18RAP | Interleukin 18 receptor accessory protein. (598 aa) |
| | IL18R1 | Interleukin 18 receptor 1. (539 aa) |
| | IL1RL1 | Interleukin 1 receptor like 1. (556 aa) |
| | IL1RL2 | Interleukin 1 receptor like 2. (575 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (569 aa) |
| | IL1R2 | Interleukin 1 receptor type 2. (418 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | OTULIN | OTU deubiquitinase with linear linkage specificity. (352 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | CARD11 | Caspase recruitment domain family member 11. (805 aa) |
| | SUGT1 | SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (333 aa) |
| | FOXO1 | Forkhead box O1. (655 aa) |
| | MCL1 | MCL1 apoptosis regulator, BCL2 family member. (350 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (467 aa) |
| | MALT1 | MALT1 paracaspase. (729 aa) |
| | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa) |
| | BCL2 | BCL2 apoptosis regulator. (239 aa) |
| | XIAP | RING-type domain-containing protein. (497 aa) |
| | SETD7 | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa) |
| | RELB | RELB proto-oncogene, NF-kB subunit. (440 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (604 aa) |
| | CASP12 | Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family. (408 aa) |
| | CASP4 | Caspase 4; Belongs to the peptidase C14A family. (377 aa) |
| | CASP5 | Caspase 5; Belongs to the peptidase C14A family. (325 aa) |
| | CASP1 | Caspase 1; Belongs to the peptidase C14A family. (462 aa) |
| | CARD16 | CARD domain-containing protein. (81 aa) |
| | ENSCSAP00000014978 | Uncharacterized protein; Belongs to the peptidase C14A family. (392 aa) |
| | CASP3 | Caspase 3; Belongs to the peptidase C14A family. (277 aa) |
| | BBC3 | Uncharacterized protein. (199 aa) |
| | APPL2 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (664 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | CARD8 | Uncharacterized protein. (444 aa) |
| | ENSCSAP00000015158 | FIIND domain-containing protein. (413 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | SPATA2L | Spermatogenesis associated 2 like. (424 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | AIM2 | Absent in melanoma 2. (343 aa) |
| | TIRAP | TIR domain containing adaptor protein. (220 aa) |
| | DIABLO | Uncharacterized protein. (239 aa) |
| | GLMP | Glycosylated lysosomal membrane protein. (406 aa) |
| | ENSCSAP00000016107 | Uncharacterized protein. (123 aa) |
| | NLRP12 | NLR family pyrin domain containing 12. (1061 aa) |
| | S100A2 | Protein S100; Belongs to the S-100 family. (98 aa) |
| | NLRP7 | NLR family pyrin domain containing 7. (861 aa) |
| | NLRP2 | NLR family pyrin domain containing 2. (1063 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1210 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (233 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (415 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (637 aa) |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (248 aa) |
| | CARD18 | Caspase recruitment domain family member 18. (90 aa) |
| | TICAM2 | Toll like receptor adaptor molecule 2. (235 aa) |
| | TIFA | TRAF interacting protein with forkhead associated domain. (185 aa) |
| | TLR2 | Toll-like receptor. (784 aa) |
| | TLR5 | Toll like receptor 5; Belongs to the Toll-like receptor family. (858 aa) |
| | TICAM1 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (711 aa) |
| | PYDC2 | Pyrin domain containing 2. (97 aa) |
| | HRK | Activator of apoptosis harakiri; Promotes apoptosis. (91 aa) |
| | ENSCSAP00000018835 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | TLR7 | Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa) |
| | TLR8 | Toll like receptor 8; Belongs to the Toll-like receptor family. (1040 aa) |
| | TLR6 | Toll-like receptor. (796 aa) |
| | TLR1 | Toll like receptor 1; Belongs to the Toll-like receptor family. (786 aa) |
| | TLR10 | Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa) |
