STRINGSTRING
EME1 EME1 SLX1 SLX1 FAN1 FAN1 ERCC4 ERCC4 SLX4 SLX4 XPA XPA FANCM FANCM ERCC5 ERCC5 BIVM BIVM ERCC1 ERCC1 ENSCSAP00000017472 ENSCSAP00000017472
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (735 aa)
SLX4Uncharacterized protein. (929 aa)
XPAXPA, DNA damage recognition and repair factor. (226 aa)
FANCMFA complementation group M. (2050 aa)
ERCC5ERCC excision repair 5, endonuclease. (1182 aa)
BIVMBasic, immunoglobulin-like variable motif containing. (503 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
ENSCSAP00000017472ERCC4 domain-containing protein. (551 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.