STRINGSTRING
VPS4A VPS4A IST1 IST1 RRAD RRAD TSG101 TSG101 UEVLD UEVLD MVB12A MVB12A CHMP2B CHMP2B VPS37C VPS37C DCAF15 DCAF15 SERPINB9 SERPINB9 ZFYVE19 ZFYVE19 VPS28 VPS28 PDCD6IP PDCD6IP CHMP5 CHMP5 UBAP1 UBAP1 CHMP4B CHMP4B STAM STAM UBAP1L UBAP1L ZFYVE1 ZFYVE1 CHMP4C CHMP4C MVB12B MVB12B MDP1 MDP1 CHMP4A CHMP4A TM9SF1 TM9SF1 STAM2 STAM2 PTPN23 PTPN23 CHMP7 CHMP7 CHMP3 CHMP3 VPS37A VPS37A ARRDC1 ARRDC1 VTA1 VTA1 VPS36 VPS36 VPS37D VPS37D VPS4B VPS4B VPS25 VPS25 CHMP1A CHMP1A SNF8 SNF8 CHMP6 CHMP6 HGS HGS VPS37B VPS37B CHMP2A CHMP2A CC2D1B CC2D1B BSDC1 BSDC1 ENSCSAP00000018918 ENSCSAP00000018918
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (437 aa)
IST1IST1 factor associated with ESCRT-III. (364 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
TSG101Tumor susceptibility 101. (390 aa)
UEVLDUEV and lactate/malate dehyrogenase domains. (461 aa)
MVB12AMultivesicular body subunit 12A. (273 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
VPS37CVPS37C subunit of ESCRT-I. (355 aa)
DCAF15DDB1 and CUL4 associated factor 15. (600 aa)
SERPINB9Serpin family B member 9; Belongs to the serpin family. (376 aa)
ZFYVE19Zinc finger FYVE-type containing 19. (395 aa)
VPS28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (231 aa)
PDCD6IPBRO1 domain-containing protein. (868 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
UBAP1Ubiquitin associated protein 1. (502 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
STAMSignal transducing adaptor molecule. (540 aa)
UBAP1LUbiquitin associated protein 1 like. (376 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (777 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
MVB12BMultivesicular body subunit 12B. (321 aa)
MDP1Magnesium dependent phosphatase 1. (175 aa)
CHMP4ACharged multivesicular body protein 4A. (222 aa)
TM9SF1Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (606 aa)
STAM2Signal transducing adaptor molecule 2. (525 aa)
PTPN23Protein tyrosine phosphatase non-receptor type 23. (1632 aa)
CHMP7Charged multivesicular body protein 7. (453 aa)
CHMP3Charged multivesicular body protein 3. (292 aa)
VPS37AVPS37A subunit of ESCRT-I. (396 aa)
ARRDC1Arrestin domain containing 1. (427 aa)
VTA1Vesicle trafficking 1. (307 aa)
VPS36Vacuolar protein sorting 36 homolog. (386 aa)
VPS37DVPS37D subunit of ESCRT-I. (251 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (444 aa)
VPS25Vacuolar protein sorting 25 homolog. (176 aa)
CHMP1ACharged multivesicular body protein 1A. (196 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
CHMP6Charged multivesicular body protein 6. (201 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
VPS37BVPS37B subunit of ESCRT-I. (285 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
CC2D1BCoiled-coil and C2 domain containing 1B. (847 aa)
BSDC1BSD domain containing 1. (430 aa)
ENSCSAP00000018918Uncharacterized protein. (133 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.