(10 nodes) Mixed, incl. Histone H4-K16 deacetylation, and N-CoR, GPS2-interacting domain network (Chlorocebus sabaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NCOR1	Nuclear receptor corepressor 1. (2445 aa)
	BCL6	BCL6 transcription repressor. (708 aa)
	KMT2E	Lysine methyltransferase 2E. (1859 aa)
	HDAC3	Hist_deacetyl domain-containing protein. (266 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (514 aa)
	HDAC9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (780 aa)
	ENSCSAP00000009705	Hist_deacetyl domain-containing protein. (114 aa)
	ENSCSAP00000009708	Hist_deacetyl domain-containing protein. (156 aa)
	TBL1X	Transducin beta like 1 X-linked. (572 aa)
	NCOR2	Nuclear receptor corepressor 2. (2521 aa)

Your Current Organism:

Chlorocebus sabaeus

NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	ENSCSAP00000009708	ENSCSAP00000005366	ENSCSAP00000009708	BCL6 transcription repressor.	Hist_deacetyl domain-containing protein.	0.470
BCL6	NCOR1	ENSCSAP00000005366	ENSCSAP00000004853	BCL6 transcription repressor.	Nuclear receptor corepressor 1.	0.967
BCL6	NCOR2	ENSCSAP00000005366	ENSCSAP00000016047	BCL6 transcription repressor.	Nuclear receptor corepressor 2.	0.962
BCL6	TBL1XR1	ENSCSAP00000005366	ENSCSAP00000009102	BCL6 transcription repressor.	Transducin beta like 1 X-linked receptor 1.	0.467
ENSCSAP00000009705	ENSCSAP00000009708	ENSCSAP00000009705	ENSCSAP00000009708	Hist_deacetyl domain-containing protein.	Hist_deacetyl domain-containing protein.	0.896
ENSCSAP00000009705	HDAC3	ENSCSAP00000009705	ENSCSAP00000008654	Hist_deacetyl domain-containing protein.	Hist_deacetyl domain-containing protein.	0.435
ENSCSAP00000009705	HDAC9	ENSCSAP00000009705	ENSCSAP00000009698	Hist_deacetyl domain-containing protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.899
ENSCSAP00000009705	NCOR1	ENSCSAP00000009705	ENSCSAP00000004853	Hist_deacetyl domain-containing protein.	Nuclear receptor corepressor 1.	0.624
ENSCSAP00000009705	NCOR2	ENSCSAP00000009705	ENSCSAP00000016047	Hist_deacetyl domain-containing protein.	Nuclear receptor corepressor 2.	0.674
ENSCSAP00000009708	BCL6	ENSCSAP00000009708	ENSCSAP00000005366	Hist_deacetyl domain-containing protein.	BCL6 transcription repressor.	0.470
ENSCSAP00000009708	ENSCSAP00000009705	ENSCSAP00000009708	ENSCSAP00000009705	Hist_deacetyl domain-containing protein.	Hist_deacetyl domain-containing protein.	0.896
ENSCSAP00000009708	HDAC9	ENSCSAP00000009708	ENSCSAP00000009698	Hist_deacetyl domain-containing protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.885
ENSCSAP00000009708	NCOR1	ENSCSAP00000009708	ENSCSAP00000004853	Hist_deacetyl domain-containing protein.	Nuclear receptor corepressor 1.	0.728
ENSCSAP00000009708	NCOR2	ENSCSAP00000009708	ENSCSAP00000016047	Hist_deacetyl domain-containing protein.	Nuclear receptor corepressor 2.	0.723
HDAC3	ENSCSAP00000009705	ENSCSAP00000008654	ENSCSAP00000009705	Hist_deacetyl domain-containing protein.	Hist_deacetyl domain-containing protein.	0.435
HDAC3	KMT2E	ENSCSAP00000008654	ENSCSAP00000007759	Hist_deacetyl domain-containing protein.	Lysine methyltransferase 2E.	0.464
HDAC3	NCOR1	ENSCSAP00000008654	ENSCSAP00000004853	Hist_deacetyl domain-containing protein.	Nuclear receptor corepressor 1.	0.993
HDAC3	NCOR2	ENSCSAP00000008654	ENSCSAP00000016047	Hist_deacetyl domain-containing protein.	Nuclear receptor corepressor 2.	0.988
HDAC3	TBL1X	ENSCSAP00000008654	ENSCSAP00000011440	Hist_deacetyl domain-containing protein.	Transducin beta like 1 X-linked.	0.889
HDAC3	TBL1XR1	ENSCSAP00000008654	ENSCSAP00000009102	Hist_deacetyl domain-containing protein.	Transducin beta like 1 X-linked receptor 1.	0.899

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