STRINGSTRING
ENSCSAP00000000080 ENSCSAP00000000080 UBA6 UBA6 UBA52 UBA52 UBE2L6 UBE2L6 OTUB1 OTUB1 UBE2D1 UBE2D1 UBD UBD LOC103232514 LOC103232514 RNF168 RNF168 UBB UBB UBE2R2 UBE2R2 RNF8 RNF8 ZFAND4 ZFAND4 RAD18 RAD18 TRAF7 TRAF7 HLTF HLTF PRKN PRKN CDC34 CDC34 UBE2G1 UBE2G1 UBA1 UBA1 ARIH1 ARIH1 RPS27A RPS27A UBA7 UBA7 ENSCSAP00000010913 ENSCSAP00000010913 TMEM189-UBE2V1 TMEM189-UBE2V1 UBE2D4 UBE2D4 ENSCSAP00000012800 ENSCSAP00000012800 UBE2K UBE2K UCHL1 UCHL1 SHPRH SHPRH UBE2A UBE2A UBC UBC PINK1 PINK1 MIB2 MIB2 UBE2NL UBE2NL ENSCSAP00000017765 ENSCSAP00000017765 UBL4B UBL4B LOC103222584 LOC103222584 ENSCSAP00000018444 ENSCSAP00000018444
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCSAP00000000080UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (199 aa)
UBA6Ubiquitin like modifier activating enzyme 6. (1052 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
UBE2L6Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
OTUB1Ubiquitin thioesterase. (280 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
UBDUbiquitin D. (165 aa)
LOC103232514RING-type domain-containing protein. (190 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
UBBUncharacterized protein. (153 aa)
UBE2R2Ubiquitin conjugating enzyme E2 R2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (485 aa)
ZFAND4Zinc finger AN1-type containing 4. (723 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (505 aa)
TRAF7TNF receptor associated factor 7. (670 aa)
HLTFHelicase like transcription factor. (1009 aa)
PRKNParkin RBR E3 ubiquitin protein ligase. (288 aa)
CDC34Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (236 aa)
UBE2G1Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
UBA1Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1058 aa)
ARIH1RBR-type E3 ubiquitin transferase. (465 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
UBA7Ubiquitin like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1012 aa)
ENSCSAP00000010913UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
TMEM189-UBE2V1TMEM189-UBE2V1 readthrough. (370 aa)
UBE2D4Ubiquitin conjugating enzyme E2 D4 (putative); Belongs to the ubiquitin-conjugating enzyme family. (177 aa)
ENSCSAP00000012800UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase. (223 aa)
SHPRHSNF2 histone linker PHD RING helicase. (1683 aa)
UBE2AUbiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
UBCUncharacterized protein. (228 aa)
PINK1PTEN induced kinase 1. (581 aa)
MIB2Mindbomb E3 ubiquitin protein ligase 2. (955 aa)
UBE2NLUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
ENSCSAP00000017765Ubiquitin-like domain-containing protein. (155 aa)
UBL4BUbiquitin like 4B. (174 aa)
LOC103222584UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
ENSCSAP00000018444Ubiquitin-like domain-containing protein. (127 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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