node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCUN1D1 | ENSCSAP00000018574 | ENSCSAP00000009382 | ENSCSAP00000018574 | DCN1-like protein. | Ubiquitin-like domain-containing protein. | 0.881 |
DCUN1D1 | NAE1 | ENSCSAP00000009382 | ENSCSAP00000000950 | DCN1-like protein. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.647 |
DCUN1D1 | SENP8 | ENSCSAP00000009382 | ENSCSAP00000019230 | DCN1-like protein. | SUMO peptidase family member, NEDD8 specific. | 0.400 |
DCUN1D1 | UBA3 | ENSCSAP00000009382 | ENSCSAP00000007844 | DCN1-like protein. | Ubiquitin like modifier activating enzyme 3. | 0.694 |
DCUN1D1 | UBE2M | ENSCSAP00000009382 | ENSCSAP00000016441 | DCN1-like protein. | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. | 0.984 |
ENSCSAP00000018574 | DCUN1D1 | ENSCSAP00000018574 | ENSCSAP00000009382 | Ubiquitin-like domain-containing protein. | DCN1-like protein. | 0.881 |
ENSCSAP00000018574 | NAE1 | ENSCSAP00000018574 | ENSCSAP00000000950 | Ubiquitin-like domain-containing protein. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.980 |
ENSCSAP00000018574 | SENP8 | ENSCSAP00000018574 | ENSCSAP00000019230 | Ubiquitin-like domain-containing protein. | SUMO peptidase family member, NEDD8 specific. | 0.993 |
ENSCSAP00000018574 | UBA3 | ENSCSAP00000018574 | ENSCSAP00000007844 | Ubiquitin-like domain-containing protein. | Ubiquitin like modifier activating enzyme 3. | 0.987 |
ENSCSAP00000018574 | UBE2M | ENSCSAP00000018574 | ENSCSAP00000016441 | Ubiquitin-like domain-containing protein. | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. | 0.992 |
NAE1 | DCUN1D1 | ENSCSAP00000000950 | ENSCSAP00000009382 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | DCN1-like protein. | 0.647 |
NAE1 | ENSCSAP00000018574 | ENSCSAP00000000950 | ENSCSAP00000018574 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | Ubiquitin-like domain-containing protein. | 0.980 |
NAE1 | SENP8 | ENSCSAP00000000950 | ENSCSAP00000019230 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | SUMO peptidase family member, NEDD8 specific. | 0.793 |
NAE1 | UBA3 | ENSCSAP00000000950 | ENSCSAP00000007844 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | Ubiquitin like modifier activating enzyme 3. | 0.998 |
NAE1 | UBE2M | ENSCSAP00000000950 | ENSCSAP00000016441 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. | 0.970 |
SENP8 | DCUN1D1 | ENSCSAP00000019230 | ENSCSAP00000009382 | SUMO peptidase family member, NEDD8 specific. | DCN1-like protein. | 0.400 |
SENP8 | ENSCSAP00000018574 | ENSCSAP00000019230 | ENSCSAP00000018574 | SUMO peptidase family member, NEDD8 specific. | Ubiquitin-like domain-containing protein. | 0.993 |
SENP8 | NAE1 | ENSCSAP00000019230 | ENSCSAP00000000950 | SUMO peptidase family member, NEDD8 specific. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.793 |
SENP8 | UBA3 | ENSCSAP00000019230 | ENSCSAP00000007844 | SUMO peptidase family member, NEDD8 specific. | Ubiquitin like modifier activating enzyme 3. | 0.849 |
SENP8 | UBE2M | ENSCSAP00000019230 | ENSCSAP00000016441 | SUMO peptidase family member, NEDD8 specific. | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. | 0.634 |