STRINGSTRING
WDR45 WDR45 GABARAPL2 GABARAPL2 CISD2 CISD2 WIPI1 WIPI1 ARFIP2 ARFIP2 BNIP3 BNIP3 SPATA18 SPATA18 AMBRA1 AMBRA1 ATG4B ATG4B FUNDC2 FUNDC2 ATG3 ATG3 ATG9B ATG9B MARK2 MARK2 ATG4D ATG4D ATG2A ATG2A ULK2 ULK2 FBXO7 FBXO7 MAP1LC3C MAP1LC3C ENSCSAP00000005633 ENSCSAP00000005633 ATG7 ATG7 PHB2 PHB2 ATG2B ATG2B TIGAR TIGAR OGT OGT TP53 TP53 MAP1LC3A MAP1LC3A PRKN PRKN FUNDC1 FUNDC1 PINK1 PINK1 ULK1 ULK1 SPATA33 SPATA33 USP30 USP30 MAP1LC3B MAP1LC3B LRBA LRBA FIS1 FIS1 TAZ TAZ WIPI2 WIPI2 RETREG1 RETREG1 C5orf51 C5orf51 SLC25A46 SLC25A46 ATG5 ATG5 RB1CC1 RB1CC1 ATG14 ATG14 FBXL4 FBXL4 SNX30 SNX30
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WDR45Uncharacterized protein. (360 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
CISD2CDGSH iron sulfur domain 2. (135 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (446 aa)
ARFIP2ADP ribosylation factor interacting protein 2. (341 aa)
BNIP3BCL2 interacting protein 3. (194 aa)
SPATA18Spermatogenesis associated 18. (538 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1208 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (393 aa)
FUNDC2FUN14 domain containing 2. (189 aa)
ATG3Autophagy-related protein 3. (314 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (922 aa)
MARK2Non-specific serine/threonine protein kinase. (733 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (474 aa)
ATG2AAutophagy related 2A. (1932 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1036 aa)
FBXO7F-box protein 7. (522 aa)
MAP1LC3CMicrotubule associated protein 1 light chain 3 gamma. (147 aa)
ENSCSAP00000005633Uncharacterized protein. (148 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (703 aa)
PHB2Prohibitin. (288 aa)
ATG2BAutophagy related 2B. (2078 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
PRKNParkin RBR E3 ubiquitin protein ligase. (288 aa)
FUNDC1Uncharacterized protein. (155 aa)
PINK1PTEN induced kinase 1. (581 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1070 aa)
SPATA33Spermatogenesis associated 33. (108 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (517 aa)
MAP1LC3BUncharacterized protein. (125 aa)
LRBALPS responsive beige-like anchor protein. (2113 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
TAZTafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (262 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (443 aa)
RETREG1Reticulophagy regulator 1. (497 aa)
C5orf51Chromosome 5 open reading frame 51. (294 aa)
SLC25A46Solute carrier family 25 member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (418 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
RB1CC1RB1 inducible coiled-coil 1. (1594 aa)
ATG14Autophagy related 14. (492 aa)
FBXL4F-box and leucine rich repeat protein 4. (621 aa)
SNX30Sorting nexin family member 30. (393 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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