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| | CBX5 | Chromobox 5. (191 aa) |
| | ATF7 | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (609 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (303 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (346 aa) |
| | SUN2 | Sad1 and UNC84 domain containing 2. (720 aa) |
| | MTA2 | Metastasis associated 1 family member 2. (668 aa) |
| | TNKS2 | Poly [ADP-ribose] polymerase. (1166 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa) |
| | SP100 | SP100 nuclear antigen. (851 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa) |
| | MEN1 | Menin 1. (610 aa) |
| | MAJIN | Membrane anchored junction protein. (253 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1036 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (735 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | PPP1R10 | Protein phosphatase 1 regulatory subunit 10. (940 aa) |
| | MACROH2A2 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | RECQL4 | RecQ like helicase 4. (1210 aa) |
| | SMC5 | SMC_N domain-containing protein. (1101 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (738 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1977 aa) |
| | TERB2 | Telomere repeat binding bouquet formation protein 2. (220 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa) |
| | SLX4 | Uncharacterized protein. (929 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (246 aa) |
| | POT1 | Protection of telomeres 1. (634 aa) |
| | CHD4 | Uncharacterized protein. (1914 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (485 aa) |
| | CTC1 | CST telomere replication complex component 1. (1209 aa) |
| | SIRT6 | Sirtuin 6. (355 aa) |
| | ATRX | ATRX chromatin remodeler. (2459 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | ENSCSAP00000007123 | RAD51_interact domain-containing protein. (319 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (354 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (549 aa) |
| | TELO2 | Telomere maintenance 2. (837 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | DHX36 | DEAH-box helicase 36. (1007 aa) |
| | NABP1 | Nucleic acid binding protein 1. (204 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | ZBTB10 | Zinc finger and BTB domain containing 10. (873 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (368 aa) |
| | CDC73 | Cell division cycle 73. (531 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (440 aa) |
| | SMG6 | SMG6 nonsense mediated mRNA decay factor. (1419 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa) |
| | PML | Promyelocytic leukemia. (819 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | HAT1 | Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4131 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (334 aa) |
| | SETX | Senataxin. (2679 aa) |
| | SSB | Small RNA binding exonuclease protection factor La. (456 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (397 aa) |
| | ENSCSAP00000011749 | G-patch domain-containing protein. (330 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | WRN | WRN RecQ like helicase. (1399 aa) |
| | HMBOX1 | Homeobox containing 1. (420 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (424 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2465 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | PARP1 | Poly(ADP-ribose) polymerase 1. (709 aa) |
| | TEP1 | Telomerase associated protein 1. (2624 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1327 aa) |
| | PINX1 | PIN2 (TERF1) interacting telomerase inhibitor 1. (328 aa) |
| | ORC3 | Origin recognition complex subunit 3. (711 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3420 aa) |
| | LRWD1 | Leucine rich repeats and WD repeat domain containing 1. (647 aa) |
| | ENSCSAP00000014397 | Uncharacterized protein. (393 aa) |
| | ZNF827 | Zinc finger protein 827. (1081 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (563 aa) |
| | CBX1 | Chromobox 1. (266 aa) |
| | GATAD2B | GATA zinc finger domain containing 2B. (593 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (532 aa) |
| | ZSCAN4 | Zinc finger and SCAN domain containing 4. (433 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (872 aa) |
| | ZBTB48 | Zinc finger and BTB domain containing 48. (688 aa) |
| | PURA | Purine rich element binding protein A. (322 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2AC1 | Histone H2A; Belongs to the histone H2A family. (131 aa) |
| | NSMCE3 | NSE3 homolog, SMC5-SMC6 complex component. (304 aa) |
| | TFIP11 | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (837 aa) |
| | TERF2IP | TERF2 interacting protein. (400 aa) |
| | GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (198 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (537 aa) |
| | TERF2 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (500 aa) |
| | TERB1 | Telomere repeat binding bouquet formation protein 1. (727 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (383 aa) |
| | TEN1 | Uncharacterized protein. (94 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1118 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa) |
| | NAT10 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa) |
