STRINGSTRING
RUNX2 RUNX2 CBFB CBFB WNT3 WNT3 MRC2 MRC2 WNT11 WNT11 LEF1 LEF1 AXIN2 AXIN2 BMPR1B BMPR1B SPP1 SPP1 IBSP IBSP MAP2K6 MAP2K6 BMP3 BMP3 RRAS2 RRAS2 GLI1 GLI1 MAPK11 MAPK11 ATP5F1B ATP5F1B LGR4 LGR4 COL1A1 COL1A1 CREB3L1 CREB3L1 CLTC CLTC DHH DHH WNT10B WNT10B ENSCSAP00000002584 ENSCSAP00000002584 SHH SHH NF1 NF1 IARS1 IARS1 COL6A1 COL6A1 MEN1 MEN1 BMP6 BMP6 ID4 ID4 ENSCSAP00000003991 ENSCSAP00000003991 RDH14 RDH14 GABBR1 GABBR1 CLEC5A CLEC5A IHH IHH LRP5 LRP5 IGFBP5 IGFBP5 HNRNPU HNRNPU COL11A2 COL11A2 MSX2 MSX2 BMPR1A BMPR1A AKT1 AKT1 IGF2 IGF2 CCN4 CCN4 SMO SMO GDF2 GDF2 GDF10 GDF10 MAPK14 MAPK14 BMPR2 BMPR2 DNAJC13 DNAJC13 SATB2 SATB2 ENSCSAP00000007626 ENSCSAP00000007626 WWTR1 WWTR1 HIRA HIRA MYOC MYOC RSPO2 RSPO2 SOX8 SOX8 CTHRC1 CTHRC1 TNN TNN TP53INP2 TP53INP2 SHOX2 SHOX2 SP7 SP7 FZD1 FZD1 TMEM119 TMEM119 JUNB JUNB JUND JUND ENSCSAP00000017740 ENSCSAP00000017740 ENSCSAP00000017683 ENSCSAP00000017683 ENSCSAP00000017599 ENSCSAP00000017599 NOG NOG EPHA2 EPHA2 ALPL ALPL GLIS1 GLIS1 CCN1 CCN1 ADAR ADAR BGLAP BGLAP MEF2D MEF2D FASN FASN SIRT7 SIRT7 ALYREF ALYREF PHB PHB HAND2 HAND2 SMAD1 SMAD1 WWOX WWOX SMAD4 SMAD4 FGF9 FGF9 ACHE ACHE SNRNP200 SNRNP200 SYNCRIP SYNCRIP ENSCSAP00000013290 ENSCSAP00000013290 FHL2 FHL2 CTNNB1 CTNNB1 GLI2 GLI2 WNT3A WNT3A LIMD1 LIMD1 PTH1R PTH1R ASF1A ASF1A IGFBP3 IGFBP3 CYP24A1 CYP24A1 GLI3 GLI3 SFRP1 SFRP1 SNAI1 SNAI1 BMP4 BMP4 SNAI2 SNAI2 MEF2C MEF2C LOX LOX PENK PENK HOXA2 HOXA2 SEMA7A SEMA7A GTPBP4 GTPBP4 BMP2 BMP2 ITGA11 ITGA11 SMAD5 SMAD5 SMAD3 SMAD3 MYBBP1A MYBBP1A UCMA UCMA DLX5 DLX5 TNC TNC IFT80 IFT80
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (450 aa)
CBFBCore-binding factor subunit beta. (187 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
MRC2Mannose receptor C type 2. (1479 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
LEF1Lymphoid enhancer binding factor 1. (331 aa)
AXIN2Axin 2. (843 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (536 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
IBSPIntegrin binding sialoprotein. (318 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (474 aa)
RRAS2RAS related 2. (204 aa)
GLI1GLI family zinc finger 1. (1106 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1495 aa)
DHHDesert hedgehog signaling molecule. (298 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ENSCSAP00000002584Prohibitin. (259 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
NF1Neurofibromin 1. (2849 aa)
IARS1Isoleucyl-tRNA synthetase. (1262 aa)
COL6A1Uncharacterized protein. (1003 aa)
MEN1Menin 1. (610 aa)
BMP6Bone morphogenetic protein 6. (433 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
ENSCSAP00000003991Uncharacterized protein. (851 aa)
RDH14Retinol dehydrogenase 14; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (336 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (962 aa)
CLEC5AC-type lectin domain containing 5A. (188 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
LRP5LDL receptor related protein 5. (1451 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (806 aa)
COL11A2Collagen type XI alpha 2 chain. (1650 aa)
MSX2Msh homeobox 2. (267 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IGF2Insulin like growth factor 2. (236 aa)
CCN4Cellular communication network factor 4. (336 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
GDF2Growth differentiation factor 2. (429 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
DNAJC13DnaJ heat shock protein family (Hsp40) member C13. (2248 aa)
SATB2DNA-binding protein SATB. (733 aa)
ENSCSAP00000007626Uncharacterized protein; Belongs to the GroES chaperonin family. (102 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
HIRAProtein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1017 aa)
MYOCMyocilin. (491 aa)
RSPO2R-spondin 2. (243 aa)
SOX8SRY-box transcription factor 8. (446 aa)
CTHRC1Collagen triple helix repeat containing 1. (243 aa)
TNNTenascin N. (1299 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (220 aa)
SHOX2Short stature homeobox 2. (331 aa)
SP7Sp7 transcription factor. (431 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (649 aa)
TMEM119Transmembrane protein 119. (280 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (348 aa)
ENSCSAP00000017740Uncharacterized protein; Belongs to the GroES chaperonin family. (97 aa)
ENSCSAP00000017683Prohibitin. (272 aa)
ENSCSAP00000017599annotation not available (271 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
EPHA2EPH receptor A2. (1033 aa)
ALPLAlkaline phosphatase. (524 aa)
GLIS1GLIS family zinc finger 1. (709 aa)
CCN1Cellular communication network factor 1. (381 aa)
ADARAdenosine deaminase RNA specific. (931 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (100 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
FASNFatty acid synthase. (2510 aa)
SIRT7Sirtuin 7. (400 aa)
ALYREFAly/REF export factor. (264 aa)
PHBProhibitin. (272 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
WWOXWW domain containing oxidoreductase. (352 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (614 aa)
SNRNP200Small nuclear ribonucleoprotein U5 subunit 200. (2136 aa)
SYNCRIPSynaptotagmin binding cytoplasmic RNA interacting protein. (562 aa)
ENSCSAP00000013290ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (507 aa)
FHL2Four and a half LIM domains 2. (279 aa)
CTNNB1Catenin beta 1. (781 aa)
GLI2GLI family zinc finger 2. (1554 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LIMD1LIM domains containing 1. (676 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (593 aa)
ASF1AAnti-silencing function 1A histone chaperone. (204 aa)
IGFBP3Insulin like growth factor binding protein 3. (291 aa)
CYP24A1Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (514 aa)
GLI3GLI family zinc finger 3. (1459 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
MEF2CMyocyte enhancer factor 2C. (446 aa)
LOXLysyl oxidase. (417 aa)
PENKProenkephalin. (267 aa)
HOXA2Homeobox A2. (373 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (501 aa)
GTPBP4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (634 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1188 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MYBBP1AMYB binding protein 1a. (1328 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (140 aa)
DLX5Distal-less homeobox 5. (289 aa)
TNCTenascin C. (2201 aa)
IFT80Intraflagellar transport 80. (768 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.