STRINGSTRING
PROX1 PROX1 LHX3 LHX3 RFX6 RFX6 NOTCH1 NOTCH1 IL31RA IL31RA CTNNB1 CTNNB1 SLC9A4 SLC9A4 GATA6 GATA6 CDH2 CDH2 PDX1 PDX1 PDPK1 PDPK1 YAP1 YAP1 RARA RARA SIDT2 SIDT2 FASN FASN WDR77 WDR77 WNT4 WNT4 NEUROD1 NEUROD1 FZD5 FZD5 ASCL1 ASCL1 BHLHA15 BHLHA15 RFX3 RFX3 TP63 TP63 NFIB NFIB RARB RARB SPDEF SPDEF GATA2 GATA2 RBM4B RBM4B BMP6 BMP6 MEN1 MEN1 RARG RARG FGF8 FGF8 SMO SMO PAX4 PAX4 EXT1 EXT1 CAV1 CAV1 NKX2-2 NKX2-2 KLF4 KLF4 DLL1 DLL1 CDK6 CDK6 WNT5A WNT5A BMP5 BMP5 AGR2 AGR2 BMP2 BMP2 NR5A2 NR5A2 CLCN2 CLCN2 HIF1A HIF1A HNF4A HNF4A HOXA5 HOXA5 GDF11 GDF11 PAX6 PAX6 FGFR2 FGFR2 NKX6-1 NKX6-1 NKX6-2 NKX6-2 BMP4 BMP4 NKX6-3 NKX6-3 FOXA1 FOXA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PROX1Prospero homeobox 1. (737 aa)
LHX3LIM homeobox 3. (402 aa)
RFX6Regulatory factor X6. (928 aa)
NOTCH1Notch receptor 1. (2555 aa)
IL31RAInterleukin 31 receptor A. (735 aa)
CTNNB1Catenin beta 1. (781 aa)
SLC9A4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (798 aa)
GATA6GATA binding protein 6. (595 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
YAP1Yes associated protein 1. (508 aa)
RARARetinoic acid receptor alpha. (462 aa)
SIDT2SID1 transmembrane family member 2. (836 aa)
FASNFatty acid synthase. (2510 aa)
WDR77WD repeat domain 77. (342 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (239 aa)
BHLHA15Basic helix-loop-helix family member a15. (194 aa)
RFX3Regulatory factor X3. (753 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (500 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
RARBRetinoic acid receptor beta. (448 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
GATA2GATA binding protein 2. (397 aa)
RBM4BRNA binding motif protein 4B. (359 aa)
BMP6Bone morphogenetic protein 6. (433 aa)
MEN1Menin 1. (610 aa)
RARGRetinoic acid receptor gamma. (443 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
PAX4Paired box 4. (343 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (420 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
NKX2-2NK2 homeobox 2. (273 aa)
KLF4Kruppel like factor 4. (479 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (543 aa)
CLCN2Chloride channel protein. (898 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
HOXA5Homeobox A5. (381 aa)
GDF11Growth differentiation factor 11. (406 aa)
PAX6Paired box 6. (436 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
NKX6-1NK6 homeobox 1. (366 aa)
NKX6-2NK6 homeobox 2. (277 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
NKX6-3Homeobox domain-containing protein. (265 aa)
FOXA1Forkhead box A1. (470 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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