STRINGSTRING
MDM4 MDM4 TMEM100 TMEM100 NOG NOG CPLANE2 CPLANE2 HEYL HEYL TBX3 TBX3 SMAD4 SMAD4 ISL1 ISL1 HEY2 HEY2 MSX1 MSX1 GATA5 GATA5 ACVR1 ACVR1 NOTCH1 NOTCH1 TGFB2 TGFB2 BMP7 BMP7 SNAI1 SNAI1 TBX20 TBX20 SNAI2 SNAI2 ENG ENG BMP2 BMP2 HEY1 HEY1 BMP5 BMP5 BMPR1A BMPR1A TGFBR2 TGFBR2 NOS3 NOS3 TBX2 TBX2 ROBO1 ROBO1 ROBO2 ROBO2 ENSCSAP00000002167 ENSCSAP00000002167 ACVRL1 ACVRL1 FGF8 FGF8 SOX9 SOX9 DCHS1 DCHS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
TMEM100Transmembrane protein 100. (134 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
TBX3T-box transcription factor 3. (723 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ISL1ISL LIM homeobox 1. (349 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
MSX1Msh homeobox 1. (303 aa)
GATA5GATA binding protein 5. (366 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
NOTCH1Notch receptor 1. (2555 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
TBX20T-box transcription factor 20. (447 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
ENGEndoglin. (658 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
NOS3Nitric oxide synthase 3. (867 aa)
TBX2T-box transcription factor 2. (588 aa)
ROBO1Uncharacterized protein. (1466 aa)
ROBO2Roundabout guidance receptor 2. (1235 aa)
ENSCSAP00000002167Ig-like domain-containing protein. (131 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SOX9SRY-box transcription factor 9. (509 aa)
DCHS1Dachsous cadherin-related 1. (3296 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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