STRINGSTRING
BMPR2 BMPR2 CRELD1 CRELD1 EGLN1 EGLN1 NRP2 NRP2 SLIT3 SLIT3 SMO SMO TEK TEK BMPR1A BMPR1A RYR2 RYR2 TGFBR2 TGFBR2 NKX2-5 NKX2-5 PLXND1 PLXND1 MYOCD MYOCD ADAMTS1 ADAMTS1 MAML1 MAML1 FOXH1 FOXH1 HEG1 HEG1 DLL4 DLL4 GREB1 GREB1 ENSCSAP00000003756 ENSCSAP00000003756 DSP DSP PKP2 PKP2 NOS3 NOS3 DCTN5 DCTN5 SMARCD3 SMARCD3 DAND5 DAND5 AP2B1 AP2B1 TBX6 TBX6 TBX2 TBX2 ANK2 ANK2 WNT11 WNT11 PDE2A PDE2A FRS2 FRS2 PARVA PARVA FGFR2 FGFR2 SALL1 SALL1 SUFU SUFU FGF8 FGF8 MKS1 MKS1 MYBPC3 MYBPC3 ENSCSAP00000002167 ENSCSAP00000002167 ROBO2 ROBO2 MYH7 MYH7 MYH6 MYH6 MYL3 MYL3 HEY2 HEY2 ENSCSAP00000012589 ENSCSAP00000012589 SLIT2 SLIT2 ISL1 ISL1 GATA4 GATA4 IGF1R IGF1R ADGRG6 ADGRG6 FHL2 FHL2 MESP1 MESP1 ENSCSAP00000013468 ENSCSAP00000013468 ZBTB14 ZBTB14 GREB1L GREB1L GATA6 GATA6 SMAD7 SMAD7 MYL10 MYL10 SMAD4 SMAD4 TGFB1 TGFB1 GSK3A GSK3A EDNRA EDNRA SFRP2 SFRP2 NPY5R NPY5R ENSCSAP00000014858 ENSCSAP00000014858 PPP1R13L PPP1R13L CPE CPE FOXF1 FOXF1 ZFPM1 ZFPM1 HAND2 HAND2 MED1 MED1 MYL2 MYL2 TBX5 TBX5 TBX3 TBX3 TNNI3 TNNI3 NOTCH2 NOTCH2 RBM15 RBM15 COL11A1 COL11A1 TGFBR3 TGFBR3 LMO4 LMO4 CCN1 CCN1 ZMPSTE24 ZMPSTE24 HEYL HEYL LUZP1 LUZP1 DHRS3 DHRS3 NOG NOG NPY2R NPY2R SOX11 SOX11 CITED2 CITED2 FOXC2 FOXC2 FZD2 FZD2 SOX4 SOX4 FOXC1 FOXC1 FZD1 FZD1 GJA5 GJA5 ROBO1 ROBO1 TGFB2 TGFB2 HECTD1 HECTD1 NRG1 NRG1 NOTCH1 NOTCH1 ACVR1 ACVR1 NSD2 NSD2 PTCD2 PTCD2 KCNK2 KCNK2 PROX1 PROX1 FGFRL1 FGFRL1 BMP7 BMP7 XIRP2 XIRP2 SALL4 SALL4 LRP2 LRP2 SAV1 SAV1 BMP10 BMP10 TBX20 TBX20 BMP4 BMP4 MEF2C MEF2C PRDM1 PRDM1 MDM4 MDM4 SCN5A SCN5A CHD7 CHD7 HOXA13 HOXA13 STRA6 STRA6 HIF1A HIF1A TNNI1 TNNI1 TNNT2 TNNT2 ENG ENG JAG1 JAG1 DNAH11 DNAH11 BMP2 BMP2 TNNC1 TNNC1 GATA3 GATA3 HEY1 HEY1 CNTRL CNTRL BMP5 BMP5 SMAD6 SMAD6 NPRL3 NPRL3 MATR3 MATR3 WNT5A WNT5A SOS1 SOS1 SHOX2 SHOX2 GRHL2 GRHL2 SEMA3C SEMA3C ZFPM2 ZFPM2 TBX1 TBX1 SRF SRF PTK7 PTK7 OVOL2 OVOL2 NDST1 NDST1 NRP1 NRP1 TP53 TP53 TRIP11 TRIP11 TGFBR1 TGFBR1 WNT2 WNT2 HAND1 HAND1 CAV3 CAV3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
CRELD1Cysteine rich with EGF like domains 1. (420 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (426 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (901 aa)
SLIT3Slit guidance ligand 3. (1320 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
TEKTEK receptor tyrosine kinase. (1123 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
RYR2Ryanodine receptor 2. (4906 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
NKX2-5NK2 homeobox 5. (324 aa)
PLXND1Plexin D1. (1833 aa)
MYOCDMyocardin. (986 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
MAML1Mastermind like transcriptional coactivator 1. (790 aa)
FOXH1Forkhead box H1. (365 aa)
HEG1Heart development protein with EGF like domains 1. (1323 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
GREB1Uncharacterized protein. (1418 aa)
ENSCSAP00000003756Uncharacterized protein. (400 aa)
DSPDesmoplakin. (2871 aa)
PKP2Plakophilin 2. (837 aa)
NOS3Nitric oxide synthase 3. (867 aa)
DCTN5Dynactin subunit 5. (182 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (470 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
AP2B1AP complex subunit beta. (951 aa)
TBX6T-box transcription factor 6. (436 aa)
TBX2T-box transcription factor 2. (588 aa)
ANK2Ankyrin 2. (4035 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PDE2APhosphodiesterase. (934 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
PARVAParvin alpha. (372 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
SALL1Spalt like transcription factor 1. (1321 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
MYBPC3Myosin binding protein C, cardiac. (1266 aa)
ENSCSAP00000002167Ig-like domain-containing protein. (131 aa)
ROBO2Roundabout guidance receptor 2. (1235 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1501 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1942 aa)
MYL3Myosin light chain 3. (197 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
ENSCSAP00000012589LRRNT domain-containing protein. (132 aa)
SLIT2Slit guidance ligand 2. (1332 aa)
ISL1ISL LIM homeobox 1. (349 aa)
GATA4GATA binding protein 4. (442 aa)
IGF1RTyrosine-protein kinase receptor. (1064 aa)
ADGRG6Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1220 aa)
FHL2Four and a half LIM domains 2. (279 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
ENSCSAP00000013468Uncharacterized protein. (1924 aa)
ZBTB14Zinc finger and BTB domain containing 14. (449 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1873 aa)
GATA6GATA binding protein 6. (595 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
MYL10Myosin light chain 10. (136 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
NPY5RNeuropeptide Y receptor Y5. (287 aa)
ENSCSAP00000014858Uncharacterized protein. (451 aa)
PPP1R13LUncharacterized protein. (518 aa)
CPECarboxypeptidase E. (476 aa)
FOXF1Forkhead box F1. (354 aa)
ZFPM1Zinc finger protein, FOG family member 1. (992 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
MYL2Myosin light chain 2. (166 aa)
TBX5T-box transcription factor 5. (518 aa)
TBX3T-box transcription factor 3. (723 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
NOTCH2Notch receptor 2. (2471 aa)
RBM15RNA binding motif protein 15. (976 aa)
COL11A1Collagen type XI alpha 1 chain. (1806 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
LMO4LIM domain only 4. (165 aa)
CCN1Cellular communication network factor 1. (381 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
LUZP1Leucine zipper protein 1. (1076 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NPY2RNeuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family. (381 aa)
SOX11Transcription factor SOX. (441 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
FOXC2Forkhead box C2. (501 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
SOX4Transcription factor SOX. (475 aa)
FOXC1Forkhead box C1. (552 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (649 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
ROBO1Uncharacterized protein. (1466 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
NRG1Neuregulin 1. (467 aa)
NOTCH1Notch receptor 1. (2555 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
PTCD2Pentatricopeptide repeat domain 2. (383 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (411 aa)
PROX1Prospero homeobox 1. (737 aa)
FGFRL1Fibroblast growth factor receptor like 1. (474 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
XIRP2Xin actin binding repeat containing 2. (3378 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
LRP2LDL receptor related protein 2. (3861 aa)
SAV1Salvador family WW domain containing protein 1. (385 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
TBX20T-box transcription factor 20. (447 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MEF2CMyocyte enhancer factor 2C. (446 aa)
PRDM1PR/SET domain 1. (825 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1881 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
HOXA13Homeobox A13. (391 aa)
STRA6Stimulated by retinoic acid 6. (659 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
TNNI1Troponin I1, slow skeletal type. (183 aa)
TNNT2Troponin T2, cardiac type. (302 aa)
ENGEndoglin. (658 aa)
JAG1Jagged canonical Notch ligand 1. (1218 aa)
DNAH11Dynein axonemal heavy chain 11. (4529 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
GATA3GATA binding protein 3. (443 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
CNTRLCentriolin. (2325 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (569 aa)
MATR3Uncharacterized protein. (847 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
SHOX2Short stature homeobox 2. (331 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
ZFPM2Zinc finger protein, FOG family member 2. (940 aa)
TBX1T-box transcription factor 1. (490 aa)
SRFSerum response factor. (508 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
OVOL2Ovo like zinc finger 2. (275 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (882 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
TRIP11Thyroid hormone receptor interactor 11. (1700 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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