STRINGSTRING
WNT11 WNT11 PDE2A PDE2A FRS2 FRS2 FGFR2 FGFR2 SALL1 SALL1 SUFU SUFU MYBPC3 MYBPC3 ENSCSAP00000002167 ENSCSAP00000002167 ROBO2 ROBO2 ROBO1 ROBO1 HOXA13 HOXA13 AP2B1 AP2B1 DAND5 DAND5 SMARCD3 SMARCD3 DCTN5 DCTN5 NOS3 NOS3 PKP2 PKP2 DSP DSP ENSCSAP00000003756 ENSCSAP00000003756 GREB1 GREB1 DLL4 DLL4 HEG1 HEG1 FOXH1 FOXH1 MYOCD MYOCD NKX2-5 NKX2-5 TGFBR2 TGFBR2 RYR2 RYR2 BMPR1A BMPR1A SLIT3 SLIT3 EGLN1 EGLN1 BMPR2 BMPR2 HAND1 HAND1 TGFBR1 TGFBR1 TRIP11 TRIP11 PTK7 PTK7 ZFPM2 ZFPM2 SEMA3C SEMA3C GRHL2 GRHL2 WNT5A WNT5A MATR3 MATR3 NPRL3 NPRL3 SMAD6 SMAD6 CNTRL CNTRL HEY1 HEY1 GATA3 GATA3 TNNC1 TNNC1 JAG1 JAG1 ENG ENG TNNT2 TNNT2 TNNI1 TNNI1 HIF1A HIF1A STRA6 STRA6 CHD7 CHD7 SCN5A SCN5A MDM4 MDM4 PRDM1 PRDM1 MEF2C MEF2C BMP4 BMP4 TBX20 TBX20 BMP10 BMP10 SAV1 SAV1 LRP2 LRP2 SALL4 SALL4 XIRP2 XIRP2 FGFRL1 FGFRL1 PROX1 PROX1 KCNK2 KCNK2 PTCD2 PTCD2 NSD2 NSD2 TGFB2 TGFB2 HECTD1 HECTD1 NRG1 NRG1 NOTCH1 NOTCH1 ACVR1 ACVR1 MYH7 MYH7 MYH6 MYH6 MYL3 MYL3 HEY2 HEY2 ENSCSAP00000012589 ENSCSAP00000012589 SLIT2 SLIT2 ISL1 ISL1 GATA4 GATA4 MESP1 MESP1 GREB1L GREB1L SMAD7 SMAD7 MYL10 MYL10 SMAD4 SMAD4 TGFB1 TGFB1 GSK3A GSK3A EDNRA EDNRA SFRP2 SFRP2 NPY5R NPY5R ENSCSAP00000014858 ENSCSAP00000014858 PPP1R13L PPP1R13L CPE CPE FOXF1 FOXF1 ZFPM1 ZFPM1 HAND2 HAND2 MED1 MED1 MYL2 MYL2 TBX5 TBX5 TBX3 TBX3 TNNI3 TNNI3 RBM15 RBM15 COL11A1 COL11A1 TGFBR3 TGFBR3 LMO4 LMO4 CCN1 CCN1 ZMPSTE24 ZMPSTE24 HEYL HEYL LUZP1 LUZP1 NOG NOG NPY2R NPY2R SOX11 SOX11 CITED2 CITED2 FOXC2 FOXC2 FZD2 FZD2 SOX4 SOX4 FOXC1 FOXC1 FZD1 FZD1 GJA5 GJA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PDE2APhosphodiesterase. (934 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
SALL1Spalt like transcription factor 1. (1321 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
MYBPC3Myosin binding protein C, cardiac. (1266 aa)
ENSCSAP00000002167Ig-like domain-containing protein. (131 aa)
ROBO2Roundabout guidance receptor 2. (1235 aa)
ROBO1Uncharacterized protein. (1466 aa)
HOXA13Homeobox A13. (391 aa)
AP2B1AP complex subunit beta. (951 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (470 aa)
DCTN5Dynactin subunit 5. (182 aa)
NOS3Nitric oxide synthase 3. (867 aa)
PKP2Plakophilin 2. (837 aa)
DSPDesmoplakin. (2871 aa)
ENSCSAP00000003756Uncharacterized protein. (400 aa)
GREB1Uncharacterized protein. (1418 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
HEG1Heart development protein with EGF like domains 1. (1323 aa)
FOXH1Forkhead box H1. (365 aa)
MYOCDMyocardin. (986 aa)
NKX2-5NK2 homeobox 5. (324 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
RYR2Ryanodine receptor 2. (4906 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SLIT3Slit guidance ligand 3. (1320 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (426 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
TRIP11Thyroid hormone receptor interactor 11. (1700 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
ZFPM2Zinc finger protein, FOG family member 2. (940 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
MATR3Uncharacterized protein. (847 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (569 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
CNTRLCentriolin. (2325 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
GATA3GATA binding protein 3. (443 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
JAG1Jagged canonical Notch ligand 1. (1218 aa)
ENGEndoglin. (658 aa)
TNNT2Troponin T2, cardiac type. (302 aa)
TNNI1Troponin I1, slow skeletal type. (183 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
STRA6Stimulated by retinoic acid 6. (659 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1881 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
PRDM1PR/SET domain 1. (825 aa)
MEF2CMyocyte enhancer factor 2C. (446 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
TBX20T-box transcription factor 20. (447 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
SAV1Salvador family WW domain containing protein 1. (385 aa)
LRP2LDL receptor related protein 2. (3861 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
XIRP2Xin actin binding repeat containing 2. (3378 aa)
FGFRL1Fibroblast growth factor receptor like 1. (474 aa)
PROX1Prospero homeobox 1. (737 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (411 aa)
PTCD2Pentatricopeptide repeat domain 2. (383 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
NRG1Neuregulin 1. (467 aa)
NOTCH1Notch receptor 1. (2555 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1501 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1942 aa)
MYL3Myosin light chain 3. (197 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
ENSCSAP00000012589LRRNT domain-containing protein. (132 aa)
SLIT2Slit guidance ligand 2. (1332 aa)
ISL1ISL LIM homeobox 1. (349 aa)
GATA4GATA binding protein 4. (442 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1873 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
MYL10Myosin light chain 10. (136 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
NPY5RNeuropeptide Y receptor Y5. (287 aa)
ENSCSAP00000014858Uncharacterized protein. (451 aa)
PPP1R13LUncharacterized protein. (518 aa)
CPECarboxypeptidase E. (476 aa)
FOXF1Forkhead box F1. (354 aa)
ZFPM1Zinc finger protein, FOG family member 1. (992 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
MYL2Myosin light chain 2. (166 aa)
TBX5T-box transcription factor 5. (518 aa)
TBX3T-box transcription factor 3. (723 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
RBM15RNA binding motif protein 15. (976 aa)
COL11A1Collagen type XI alpha 1 chain. (1806 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
LMO4LIM domain only 4. (165 aa)
CCN1Cellular communication network factor 1. (381 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
LUZP1Leucine zipper protein 1. (1076 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NPY2RNeuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family. (381 aa)
SOX11Transcription factor SOX. (441 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
FOXC2Forkhead box C2. (501 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
SOX4Transcription factor SOX. (475 aa)
FOXC1Forkhead box C1. (552 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (649 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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