STRINGSTRING
AP2B1 AP2B1 WNT11 WNT11 PDE2A PDE2A FRS2 FRS2 FGFR2 FGFR2 SALL1 SALL1 SUFU SUFU ENSCSAP00000002167 ENSCSAP00000002167 ROBO2 ROBO2 ROBO1 ROBO1 DAND5 DAND5 DCTN5 DCTN5 NOS3 NOS3 HEG1 HEG1 NKX2-5 NKX2-5 TGFBR2 TGFBR2 BMPR1A BMPR1A SLIT3 SLIT3 EGLN1 EGLN1 BMPR2 BMPR2 TGFBR1 TGFBR1 TRIP11 TRIP11 PTK7 PTK7 ZFPM2 ZFPM2 WNT5A WNT5A MATR3 MATR3 NPRL3 NPRL3 SMAD6 SMAD6 CNTRL CNTRL HEY1 HEY1 GATA3 GATA3 STRA6 STRA6 HOXA13 HOXA13 MDM4 MDM4 PRDM1 PRDM1 BMP4 BMP4 SAV1 SAV1 LRP2 LRP2 SALL4 SALL4 XIRP2 XIRP2 FGFRL1 FGFRL1 PROX1 PROX1 NSD2 NSD2 TGFB2 TGFB2 HECTD1 HECTD1 NOTCH1 NOTCH1 ACVR1 ACVR1 HEY2 HEY2 ENSCSAP00000012589 ENSCSAP00000012589 SLIT2 SLIT2 GATA4 GATA4 SMAD7 SMAD7 SMAD4 SMAD4 ZFPM1 ZFPM1 TBX5 TBX5 TBX3 TBX3 RBM15 RBM15 TGFBR3 TGFBR3 LMO4 LMO4 CCN1 CCN1 HEYL HEYL LUZP1 LUZP1 NOG NOG SOX11 SOX11 CITED2 CITED2 FZD2 FZD2 SOX4 SOX4 FZD1 FZD1 GJA5 GJA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AP2B1AP complex subunit beta. (951 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PDE2APhosphodiesterase. (934 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
SALL1Spalt like transcription factor 1. (1321 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
ENSCSAP00000002167Ig-like domain-containing protein. (131 aa)
ROBO2Roundabout guidance receptor 2. (1235 aa)
ROBO1Uncharacterized protein. (1466 aa)
DAND5DAN domain BMP antagonist family member 5. (189 aa)
DCTN5Dynactin subunit 5. (182 aa)
NOS3Nitric oxide synthase 3. (867 aa)
HEG1Heart development protein with EGF like domains 1. (1323 aa)
NKX2-5NK2 homeobox 5. (324 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SLIT3Slit guidance ligand 3. (1320 aa)
EGLN1Egl-9 family hypoxia inducible factor 1. (426 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
TRIP11Thyroid hormone receptor interactor 11. (1700 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
ZFPM2Zinc finger protein, FOG family member 2. (940 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
MATR3Uncharacterized protein. (847 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (569 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
CNTRLCentriolin. (2325 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
GATA3GATA binding protein 3. (443 aa)
STRA6Stimulated by retinoic acid 6. (659 aa)
HOXA13Homeobox A13. (391 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
PRDM1PR/SET domain 1. (825 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SAV1Salvador family WW domain containing protein 1. (385 aa)
LRP2LDL receptor related protein 2. (3861 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
XIRP2Xin actin binding repeat containing 2. (3378 aa)
FGFRL1Fibroblast growth factor receptor like 1. (474 aa)
PROX1Prospero homeobox 1. (737 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1365 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
NOTCH1Notch receptor 1. (2555 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
ENSCSAP00000012589LRRNT domain-containing protein. (132 aa)
SLIT2Slit guidance ligand 2. (1332 aa)
GATA4GATA binding protein 4. (442 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ZFPM1Zinc finger protein, FOG family member 1. (992 aa)
TBX5T-box transcription factor 5. (518 aa)
TBX3T-box transcription factor 3. (723 aa)
RBM15RNA binding motif protein 15. (976 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
LMO4LIM domain only 4. (165 aa)
CCN1Cellular communication network factor 1. (381 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
LUZP1Leucine zipper protein 1. (1076 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SOX11Transcription factor SOX. (441 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
SOX4Transcription factor SOX. (475 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (649 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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