STRINGSTRING
RNASEH1 RNASEH1 APLF APLF NUDT12 NUDT12 REXO4 REXO4 PRORP PRORP UBXN8 UBXN8 KHNYN KHNYN NYNRIN NYNRIN ZRANB3 ZRANB3 PIWIL2 PIWIL2 RNASE4 RNASE4 LOC103231340 LOC103231340 LOC103231340-2 LOC103231340-2 PELO PELO TSN TSN N4BP2 N4BP2 DROSHA DROSHA ZC3H12D ZC3H12D ERCC5 ERCC5 BIVM BIVM DIS3 DIS3 RBBP8 RBBP8 DNASE1L1 DNASE1L1 PMS2 PMS2 N4BP2L1 N4BP2L1 POP7 POP7 ELAC1 ELAC1 ENSCSAP00000014110 ENSCSAP00000014110 MRE11 MRE11 ENDOD1 ENDOD1 ZC3H12C ZC3H12C PNKP PNKP ENDOV ENDOV POP5 POP5 PIWIL1 PIWIL1 TSEN34 TSEN34 DNASE2B DNASE2B ZC3H12A ZC3H12A AGO3 AGO3 AGO4 AGO4 PPP1R8 PPP1R8 INTS11 INTS11 ENSCSAP00000017472 ENSCSAP00000017472 ERVMER34-1 ERVMER34-1 RNASE11 RNASE11 RNASE6 RNASE6 RNASE1 RNASE1 RNASE2 RNASE2 RNASE7 RNASE7 RNASE8 RNASE8 RPP38 RPP38 MBLAC1 MBLAC1 RIDA RIDA ERVV-2 ERVV-2 RPP25 RPP25 PXDNL PXDNL APEX2 APEX2 RNASET2 RNASET2 RPP14 RPP14 DNASE1L3 DNASE1L3 RNASEK RNASEK POP1 POP1 RNASEL RNASEL ARID3A ARID3A TSEN15 TSEN15 SWT1 SWT1 DCLRE1C DCLRE1C SMG6 SMG6 LACTB2 LACTB2 ENDOG ENDOG EXOG EXOG EXO1 EXO1 ELAC2 ELAC2 MBD4 MBD4 RCL1 RCL1 PLD6 PLD6 RPP21 RPP21 ERCC4 ERCC4 GEN1 GEN1 MRPL44 MRPL44 DNA2 DNA2 RPP40 RPP40 YBEY YBEY CPSF3 CPSF3 FAN1 FAN1 ENDOU ENDOU RPP30 RPP30 ERN2 ERN2 RNASEH2A RNASEH2A DNASE2 DNASE2 FEN1 FEN1 SLX1 SLX1 RAD51C RAD51C ANKLE1 ANKLE1 RAG1 RAG1 EME1 EME1 TTC38 TTC38 POP4 POP4 TSEN54 TSEN54 NOB1 NOB1 ERN1 ERN1 RPS3 RPS3 ZGRF1 ZGRF1 ZC3H12B ZC3H12B LAS1L LAS1L EME2 EME2 NTHL1 NTHL1 SETMAR SETMAR DBR1 DBR1 G3BP1 G3BP1 DNASE1L2 DNASE1L2 DICER1 DICER1 OGG1 OGG1 PGBD5 PGBD5 NUDT16 NUDT16 PIWIL3 PIWIL3 SND1 SND1 DNASE1 DNASE1 TSEN2 TSEN2 AGO2 AGO2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RNASEH1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (286 aa)
APLFAprataxin and PNKP like factor. (511 aa)
NUDT12Nudix hydrolase 12. (462 aa)
REXO4REX4 homolog, 3'-5' exonuclease. (422 aa)
PRORPUncharacterized protein. (581 aa)
UBXN8UBX domain protein 8. (269 aa)
KHNYNKH and NYN domain containing. (678 aa)
NYNRINNYN domain and retroviral integrase containing. (1898 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (1016 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (973 aa)
RNASE4Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (147 aa)
LOC103231340DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
LOC103231340-2DNA-(apurinic or apyrimidinic site) lyase. (318 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
TSNTranslin. (228 aa)
N4BP2NEDD4 binding protein 2. (1770 aa)
DROSHADrosha ribonuclease III. (1379 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (530 aa)
ERCC5ERCC excision repair 5, endonuclease. (1182 aa)
BIVMBasic, immunoglobulin-like variable motif containing. (503 aa)
DIS3DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa)
RBBP8RB binding protein 8, endonuclease. (897 aa)
DNASE1L1Deoxyribonuclease; Belongs to the DNase I family. (302 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (862 aa)
N4BP2L1NEDD4 binding protein 2 like 1. (229 aa)
POP7Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. (140 aa)
ELAC1ElaC ribonuclease Z 1. (279 aa)
ENSCSAP00000014110Uncharacterized protein. (86 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
ENDOD1Endonuclease domain containing 1. (500 aa)
ZC3H12CZinc finger CCCH-type containing 12C. (884 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (521 aa)
ENDOVEndonuclease V. (308 aa)
POP5Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (163 aa)
PIWIL1Piwi like RNA-mediated gene silencing 1; Belongs to the argonaute family. (861 aa)
TSEN34tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (310 aa)
DNASE2BDeoxyribonuclease 2 beta. (361 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
PPP1R8Protein phosphatase 1 regulatory subunit 8. (351 aa)
INTS11Integrator complex subunit 11. (600 aa)
ENSCSAP00000017472ERCC4 domain-containing protein. (551 aa)
ERVMER34-1Endogenous retrovirus group MER34 member 1, envelope. (562 aa)
RNASE11Ribonuclease A family member 11 (inactive); Belongs to the pancreatic ribonuclease family. (199 aa)
RNASE6Ribonuclease A family member k6; Belongs to the pancreatic ribonuclease family. (150 aa)
RNASE1Ribonuclease A family member 1, pancreatic; Belongs to the pancreatic ribonuclease family. (152 aa)
RNASE2Ribonuclease A family member 2; Belongs to the pancreatic ribonuclease family. (160 aa)
RNASE7RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (156 aa)
RNASE8Ribonuclease A family member 8; Belongs to the pancreatic ribonuclease family. (154 aa)
RPP38Ribonuclease P/MRP subunit p38. (282 aa)
MBLAC1Metallo-beta-lactamase domain containing 1. (266 aa)
RIDAUncharacterized protein. (137 aa)
ERVV-2Uncharacterized protein. (537 aa)
RPP25Ribonuclease P and MRP subunit p25. (199 aa)
PXDNLPeroxidasin like. (1336 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa)
RNASET2Uncharacterized protein; Belongs to the RNase T2 family. (218 aa)
RPP14Ribonuclease P/MRP subunit p14. (71 aa)
DNASE1L3Deoxyribonuclease 1 like 3. (165 aa)
RNASEKRibonuclease K. (137 aa)
POP1POP1 homolog, ribonuclease P/MRP subunit. (929 aa)
RNASELRibonuclease L. (741 aa)
ARID3AAT-rich interaction domain 3A. (498 aa)
TSEN15tRNA splicing endonuclease subunit 15. (183 aa)
SWT1SWT1 RNA endoribonuclease homolog. (903 aa)
DCLRE1CDNA cross-link repair 1C. (639 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1419 aa)
LACTB2Lactamase beta 2. (288 aa)
ENDOGEndonuclease. (299 aa)
EXOGExo/endonuclease G. (344 aa)
EXO1Exonuclease 1. (845 aa)
ELAC2ElaC ribonuclease Z 2. (826 aa)
MBD4Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (572 aa)
RCL1RNA terminal phosphate cyclase like 1. (373 aa)
PLD6Phospholipase D family member 6. (249 aa)
RPP21Ribonuclease P/MRP subunit p21. (154 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (735 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (907 aa)
MRPL44Mitochondrial ribosomal protein L44. (280 aa)
DNA2DNA replication helicase/nuclease 2. (1061 aa)
RPP40Ribonuclease P/MRP subunit p40. (363 aa)
YBEYYbeY metalloendoribonuclease. (147 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (631 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
ENDOUEndonuclease, poly(U) specific. (391 aa)
RPP30Ribonuclease P/MRP subunit p30. (268 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (929 aa)
RNASEH2ARibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (300 aa)
DNASE2Deoxyribonuclease 2, lysosomal. (251 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (346 aa)
SLX1Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
RAD51CRAD51 paralog C. (367 aa)
ANKLE1Ankyrin repeat and LEM domain containing 1. (615 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (953 aa)
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
TTC38Tetratricopeptide repeat domain 38. (475 aa)
POP4Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (218 aa)
TSEN54tRNA splicing endonuclease subunit 54. (526 aa)
NOB1RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (412 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (977 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
ZGRF1Zinc finger GRF-type containing 1. (2109 aa)
ZC3H12BUncharacterized protein. (333 aa)
LAS1LLAS1 like, ribosome biogenesis factor. (722 aa)
EME2Essential meiotic structure-specific endonuclease subunit 2. (383 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa)
SETMARSET domain and mariner transposase fusion gene. (684 aa)
DBR1Debranching RNA lariats 1. (544 aa)
G3BP1G3BP stress granule assembly factor 1. (466 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (279 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1920 aa)
OGG18-oxoguanine DNA glycosylase. (405 aa)
PGBD5PiggyBac transposable element derived 5. (524 aa)
NUDT16Nudix hydrolase 16. (195 aa)
PIWIL3Piwi like RNA-mediated gene silencing 3; Belongs to the argonaute family. (870 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
DNASE1Deoxyribonuclease; Belongs to the DNase I family. (288 aa)
TSEN2tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (466 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (904 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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