120 items (Chlorocebus sabaeus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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experimentally determined

Predicted Interactions

gene neighborhood

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	RNASEH1	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (286 aa)
	APLF	Aprataxin and PNKP like factor. (511 aa)
	NUDT12	Nudix hydrolase 12. (462 aa)
	REXO4	REX4 homolog, 3'-5' exonuclease. (422 aa)
	PRORP	Uncharacterized protein. (581 aa)
	UBXN8	UBX domain protein 8. (269 aa)
	KHNYN	KH and NYN domain containing. (678 aa)
	NYNRIN	NYN domain and retroviral integrase containing. (1898 aa)
	ZRANB3	Zinc finger RANBP2-type containing 3. (1016 aa)
	PIWIL2	Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (973 aa)
	RNASE4	Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (147 aa)
	LOC103231340	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
	LOC103231340-2	DNA-(apurinic or apyrimidinic site) lyase. (318 aa)
	PELO	Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
	TSN	Translin. (228 aa)
	N4BP2	NEDD4 binding protein 2. (1770 aa)
	DROSHA	Drosha ribonuclease III. (1379 aa)
	ZC3H12D	Zinc finger CCCH-type containing 12D. (530 aa)
	ERCC5	ERCC excision repair 5, endonuclease. (1182 aa)
	BIVM	Basic, immunoglobulin-like variable motif containing. (503 aa)
	DIS3	DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa)
	RBBP8	RB binding protein 8, endonuclease. (897 aa)
	DNASE1L1	Deoxyribonuclease; Belongs to the DNase I family. (302 aa)
	PMS2	PMS1 homolog 2, mismatch repair system component. (862 aa)
	N4BP2L1	NEDD4 binding protein 2 like 1. (229 aa)
	POP7	Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. (140 aa)
	ELAC1	ElaC ribonuclease Z 1. (279 aa)
	ENSCSAP00000014110	Uncharacterized protein. (86 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
	ENDOD1	Endonuclease domain containing 1. (500 aa)
	ZC3H12C	Zinc finger CCCH-type containing 12C. (884 aa)
	PNKP	Polynucleotide kinase 3'-phosphatase. (521 aa)
	ENDOV	Endonuclease V. (308 aa)
	POP5	Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (163 aa)
	PIWIL1	Piwi like RNA-mediated gene silencing 1; Belongs to the argonaute family. (861 aa)
	TSEN34	tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (310 aa)
	DNASE2B	Deoxyribonuclease 2 beta. (361 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (601 aa)
	AGO3	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
	PPP1R8	Protein phosphatase 1 regulatory subunit 8. (351 aa)
	INTS11	Integrator complex subunit 11. (600 aa)
	ENSCSAP00000017472	ERCC4 domain-containing protein. (551 aa)
	ERVMER34-1	Endogenous retrovirus group MER34 member 1, envelope. (562 aa)
	RNASE11	Ribonuclease A family member 11 (inactive); Belongs to the pancreatic ribonuclease family. (199 aa)
	RNASE6	Ribonuclease A family member k6; Belongs to the pancreatic ribonuclease family. (150 aa)
	RNASE1	Ribonuclease A family member 1, pancreatic; Belongs to the pancreatic ribonuclease family. (152 aa)
	RNASE2	Ribonuclease A family member 2; Belongs to the pancreatic ribonuclease family. (160 aa)
	RNASE7	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (156 aa)
	RNASE8	Ribonuclease A family member 8; Belongs to the pancreatic ribonuclease family. (154 aa)
	RPP38	Ribonuclease P/MRP subunit p38. (282 aa)
	MBLAC1	Metallo-beta-lactamase domain containing 1. (266 aa)
	RIDA	Uncharacterized protein. (137 aa)
	ERVV-2	Uncharacterized protein. (537 aa)
	RPP25	Ribonuclease P and MRP subunit p25. (199 aa)
	PXDNL	Peroxidasin like. (1336 aa)
	APEX2	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa)
	RNASET2	Uncharacterized protein; Belongs to the RNase T2 family. (218 aa)
	RPP14	Ribonuclease P/MRP subunit p14. (71 aa)
	DNASE1L3	Deoxyribonuclease 1 like 3. (165 aa)
	RNASEK	Ribonuclease K. (137 aa)
	POP1	POP1 homolog, ribonuclease P/MRP subunit. (929 aa)
	RNASEL	Ribonuclease L. (741 aa)
	ARID3A	AT-rich interaction domain 3A. (498 aa)
	TSEN15	tRNA splicing endonuclease subunit 15. (183 aa)
	SWT1	SWT1 RNA endoribonuclease homolog. (903 aa)
	DCLRE1C	DNA cross-link repair 1C. (639 aa)
	SMG6	SMG6 nonsense mediated mRNA decay factor. (1419 aa)
	LACTB2	Lactamase beta 2. (288 aa)
	ENDOG	Endonuclease. (299 aa)
	EXOG	Exo/endonuclease G. (344 aa)
	EXO1	Exonuclease 1. (845 aa)
	ELAC2	ElaC ribonuclease Z 2. (826 aa)
	MBD4	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (572 aa)
	RCL1	RNA terminal phosphate cyclase like 1. (373 aa)
	PLD6	Phospholipase D family member 6. (249 aa)
	RPP21	Ribonuclease P/MRP subunit p21. (154 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (735 aa)
	GEN1	GEN1 Holliday junction 5' flap endonuclease. (907 aa)
	MRPL44	Mitochondrial ribosomal protein L44. (280 aa)
	DNA2	DNA replication helicase/nuclease 2. (1061 aa)
	RPP40	Ribonuclease P/MRP subunit p40. (363 aa)
	YBEY	YbeY metalloendoribonuclease. (147 aa)
	CPSF3	Cleavage and polyadenylation specific factor 3. (631 aa)
	FAN1	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa)
	ENDOU	Endonuclease, poly(U) specific. (391 aa)
	RPP30	Ribonuclease P/MRP subunit p30. (268 aa)
	ERN2	Endoplasmic reticulum to nucleus signaling 2. (929 aa)
	RNASEH2A	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (300 aa)
	DNASE2	Deoxyribonuclease 2, lysosomal. (251 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (346 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
	RAD51C	RAD51 paralog C. (367 aa)
	ANKLE1	Ankyrin repeat and LEM domain containing 1. (615 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (953 aa)
	EME1	Essential meiotic structure-specific endonuclease 1. (571 aa)
	TTC38	Tetratricopeptide repeat domain 38. (475 aa)
	POP4	Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (218 aa)
	TSEN54	tRNA splicing endonuclease subunit 54. (526 aa)
	NOB1	RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (412 aa)
	ERN1	Endoplasmic reticulum to nucleus signaling 1. (977 aa)
	RPS3	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	ZGRF1	Zinc finger GRF-type containing 1. (2109 aa)
	ZC3H12B	Uncharacterized protein. (333 aa)
	LAS1L	LAS1 like, ribosome biogenesis factor. (722 aa)
	EME2	Essential meiotic structure-specific endonuclease subunit 2. (383 aa)
	NTHL1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa)
	SETMAR	SET domain and mariner transposase fusion gene. (684 aa)
	DBR1	Debranching RNA lariats 1. (544 aa)
	G3BP1	G3BP stress granule assembly factor 1. (466 aa)
	DNASE1L2	Deoxyribonuclease; Belongs to the DNase I family. (279 aa)
	DICER1	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1920 aa)
	OGG1	8-oxoguanine DNA glycosylase. (405 aa)
	PGBD5	PiggyBac transposable element derived 5. (524 aa)
	NUDT16	Nudix hydrolase 16. (195 aa)
	PIWIL3	Piwi like RNA-mediated gene silencing 3; Belongs to the argonaute family. (870 aa)
	SND1	Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
	DNASE1	Deoxyribonuclease; Belongs to the DNase I family. (288 aa)
	TSEN2	tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (466 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (904 aa)

Your Current Organism:

Chlorocebus sabaeus

NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	AGO3	ENSCSAP00000005830	ENSCSAP00000016921	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.935
AGO2	AGO4	ENSCSAP00000005830	ENSCSAP00000016923	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.898
AGO2	DICER1	ENSCSAP00000005830	ENSCSAP00000006910	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.980
AGO2	DROSHA	ENSCSAP00000005830	ENSCSAP00000013240	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Drosha ribonuclease III.	0.958
AGO2	G3BP1	ENSCSAP00000005830	ENSCSAP00000007095	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	G3BP stress granule assembly factor 1.	0.451
AGO2	MRPL44	ENSCSAP00000005830	ENSCSAP00000004000	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Mitochondrial ribosomal protein L44.	0.695
AGO2	RNASEL	ENSCSAP00000005830	ENSCSAP00000008696	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Ribonuclease L.	0.427
AGO2	SND1	ENSCSAP00000005830	ENSCSAP00000006417	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.	0.695
AGO2	TSN	ENSCSAP00000005830	ENSCSAP00000012769	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Translin.	0.852
AGO3	AGO2	ENSCSAP00000016921	ENSCSAP00000005830	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.935
AGO3	AGO4	ENSCSAP00000016921	ENSCSAP00000016923	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.691
AGO3	DICER1	ENSCSAP00000016921	ENSCSAP00000006910	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	0.904
AGO3	DROSHA	ENSCSAP00000016921	ENSCSAP00000013240	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Drosha ribonuclease III.	0.832
AGO3	MRPL44	ENSCSAP00000016921	ENSCSAP00000004000	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Mitochondrial ribosomal protein L44.	0.695
AGO3	RNASEL	ENSCSAP00000016921	ENSCSAP00000008696	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Ribonuclease L.	0.481
AGO3	RPP14	ENSCSAP00000016921	ENSCSAP00000008364	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Ribonuclease P/MRP subunit p14.	0.409
AGO3	SND1	ENSCSAP00000016921	ENSCSAP00000006417	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.	0.582
AGO3	TSN	ENSCSAP00000016921	ENSCSAP00000012769	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Translin.	0.751
AGO4	AGO2	ENSCSAP00000016923	ENSCSAP00000005830	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.898
AGO4	AGO3	ENSCSAP00000016923	ENSCSAP00000016921	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.691

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