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RNASEH1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (286 aa) | ||||
APLF | Aprataxin and PNKP like factor. (511 aa) | ||||
NUDT12 | Nudix hydrolase 12. (462 aa) | ||||
REXO4 | REX4 homolog, 3'-5' exonuclease. (422 aa) | ||||
PRORP | Uncharacterized protein. (581 aa) | ||||
UBXN8 | UBX domain protein 8. (269 aa) | ||||
KHNYN | KH and NYN domain containing. (678 aa) | ||||
NYNRIN | NYN domain and retroviral integrase containing. (1898 aa) | ||||
ZRANB3 | Zinc finger RANBP2-type containing 3. (1016 aa) | ||||
PIWIL2 | Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (973 aa) | ||||
RNASE4 | Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (147 aa) | ||||
LOC103231340 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa) | ||||
LOC103231340-2 | DNA-(apurinic or apyrimidinic site) lyase. (318 aa) | ||||
PELO | Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa) | ||||
TSN | Translin. (228 aa) | ||||
N4BP2 | NEDD4 binding protein 2. (1770 aa) | ||||
DROSHA | Drosha ribonuclease III. (1379 aa) | ||||
ZC3H12D | Zinc finger CCCH-type containing 12D. (530 aa) | ||||
ERCC5 | ERCC excision repair 5, endonuclease. (1182 aa) | ||||
BIVM | Basic, immunoglobulin-like variable motif containing. (503 aa) | ||||
DIS3 | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa) | ||||
RBBP8 | RB binding protein 8, endonuclease. (897 aa) | ||||
DNASE1L1 | Deoxyribonuclease; Belongs to the DNase I family. (302 aa) | ||||
PMS2 | PMS1 homolog 2, mismatch repair system component. (862 aa) | ||||
N4BP2L1 | NEDD4 binding protein 2 like 1. (229 aa) | ||||
POP7 | Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. (140 aa) | ||||
ELAC1 | ElaC ribonuclease Z 1. (279 aa) | ||||
ENSCSAP00000014110 | Uncharacterized protein. (86 aa) | ||||
MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) | ||||
ENDOD1 | Endonuclease domain containing 1. (500 aa) | ||||
ZC3H12C | Zinc finger CCCH-type containing 12C. (884 aa) | ||||
PNKP | Polynucleotide kinase 3'-phosphatase. (521 aa) | ||||
ENDOV | Endonuclease V. (308 aa) | ||||
POP5 | Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (163 aa) | ||||
PIWIL1 | Piwi like RNA-mediated gene silencing 1; Belongs to the argonaute family. (861 aa) | ||||
TSEN34 | tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (310 aa) | ||||
DNASE2B | Deoxyribonuclease 2 beta. (361 aa) | ||||
ZC3H12A | Zinc finger CCCH-type containing 12A. (601 aa) | ||||
AGO3 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa) | ||||
AGO4 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa) | ||||
PPP1R8 | Protein phosphatase 1 regulatory subunit 8. (351 aa) | ||||
INTS11 | Integrator complex subunit 11. (600 aa) | ||||
ENSCSAP00000017472 | ERCC4 domain-containing protein. (551 aa) | ||||
ERVMER34-1 | Endogenous retrovirus group MER34 member 1, envelope. (562 aa) | ||||
RNASE11 | Ribonuclease A family member 11 (inactive); Belongs to the pancreatic ribonuclease family. (199 aa) | ||||
RNASE6 | Ribonuclease A family member k6; Belongs to the pancreatic ribonuclease family. (150 aa) | ||||
RNASE1 | Ribonuclease A family member 1, pancreatic; Belongs to the pancreatic ribonuclease family. (152 aa) | ||||
RNASE2 | Ribonuclease A family member 2; Belongs to the pancreatic ribonuclease family. (160 aa) | ||||
RNASE7 | RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (156 aa) | ||||
RNASE8 | Ribonuclease A family member 8; Belongs to the pancreatic ribonuclease family. (154 aa) | ||||
RPP38 | Ribonuclease P/MRP subunit p38. (282 aa) | ||||
MBLAC1 | Metallo-beta-lactamase domain containing 1. (266 aa) | ||||
RIDA | Uncharacterized protein. (137 aa) | ||||
ERVV-2 | Uncharacterized protein. (537 aa) | ||||
RPP25 | Ribonuclease P and MRP subunit p25. (199 aa) | ||||
PXDNL | Peroxidasin like. (1336 aa) | ||||
APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa) | ||||
RNASET2 | Uncharacterized protein; Belongs to the RNase T2 family. (218 aa) | ||||
RPP14 | Ribonuclease P/MRP subunit p14. (71 aa) | ||||
DNASE1L3 | Deoxyribonuclease 1 like 3. (165 aa) | ||||
RNASEK | Ribonuclease K. (137 aa) | ||||
POP1 | POP1 homolog, ribonuclease P/MRP subunit. (929 aa) | ||||
RNASEL | Ribonuclease L. (741 aa) | ||||
ARID3A | AT-rich interaction domain 3A. (498 aa) | ||||
TSEN15 | tRNA splicing endonuclease subunit 15. (183 aa) | ||||
SWT1 | SWT1 RNA endoribonuclease homolog. (903 aa) | ||||
DCLRE1C | DNA cross-link repair 1C. (639 aa) | ||||
SMG6 | SMG6 nonsense mediated mRNA decay factor. (1419 aa) | ||||
LACTB2 | Lactamase beta 2. (288 aa) | ||||
ENDOG | Endonuclease. (299 aa) | ||||
EXOG | Exo/endonuclease G. (344 aa) | ||||
EXO1 | Exonuclease 1. (845 aa) | ||||
ELAC2 | ElaC ribonuclease Z 2. (826 aa) | ||||
MBD4 | Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (572 aa) | ||||
RCL1 | RNA terminal phosphate cyclase like 1. (373 aa) | ||||
PLD6 | Phospholipase D family member 6. (249 aa) | ||||
RPP21 | Ribonuclease P/MRP subunit p21. (154 aa) | ||||
ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (735 aa) | ||||
GEN1 | GEN1 Holliday junction 5' flap endonuclease. (907 aa) | ||||
MRPL44 | Mitochondrial ribosomal protein L44. (280 aa) | ||||
DNA2 | DNA replication helicase/nuclease 2. (1061 aa) | ||||
RPP40 | Ribonuclease P/MRP subunit p40. (363 aa) | ||||
YBEY | YbeY metalloendoribonuclease. (147 aa) | ||||
CPSF3 | Cleavage and polyadenylation specific factor 3. (631 aa) | ||||
FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa) | ||||
ENDOU | Endonuclease, poly(U) specific. (391 aa) | ||||
RPP30 | Ribonuclease P/MRP subunit p30. (268 aa) | ||||
ERN2 | Endoplasmic reticulum to nucleus signaling 2. (929 aa) | ||||
RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (300 aa) | ||||
DNASE2 | Deoxyribonuclease 2, lysosomal. (251 aa) | ||||
FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (346 aa) | ||||
SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) | ||||
RAD51C | RAD51 paralog C. (367 aa) | ||||
ANKLE1 | Ankyrin repeat and LEM domain containing 1. (615 aa) | ||||
RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (953 aa) | ||||
EME1 | Essential meiotic structure-specific endonuclease 1. (571 aa) | ||||
TTC38 | Tetratricopeptide repeat domain 38. (475 aa) | ||||
POP4 | Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (218 aa) | ||||
TSEN54 | tRNA splicing endonuclease subunit 54. (526 aa) | ||||
NOB1 | RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (412 aa) | ||||
ERN1 | Endoplasmic reticulum to nucleus signaling 1. (977 aa) | ||||
RPS3 | Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa) | ||||
ZGRF1 | Zinc finger GRF-type containing 1. (2109 aa) | ||||
ZC3H12B | Uncharacterized protein. (333 aa) | ||||
LAS1L | LAS1 like, ribosome biogenesis factor. (722 aa) | ||||
EME2 | Essential meiotic structure-specific endonuclease subunit 2. (383 aa) | ||||
NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa) | ||||
SETMAR | SET domain and mariner transposase fusion gene. (684 aa) | ||||
DBR1 | Debranching RNA lariats 1. (544 aa) | ||||
G3BP1 | G3BP stress granule assembly factor 1. (466 aa) | ||||
DNASE1L2 | Deoxyribonuclease; Belongs to the DNase I family. (279 aa) | ||||
DICER1 | Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1920 aa) | ||||
OGG1 | 8-oxoguanine DNA glycosylase. (405 aa) | ||||
PGBD5 | PiggyBac transposable element derived 5. (524 aa) | ||||
NUDT16 | Nudix hydrolase 16. (195 aa) | ||||
PIWIL3 | Piwi like RNA-mediated gene silencing 3; Belongs to the argonaute family. (870 aa) | ||||
SND1 | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa) | ||||
DNASE1 | Deoxyribonuclease; Belongs to the DNase I family. (288 aa) | ||||
TSEN2 | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (466 aa) | ||||
AGO2 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (904 aa) |