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| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa) |
| | POLG2 | DNA polymerase gamma 2, accessory subunit. (485 aa) |
| | POLD3 | Uncharacterized protein. (466 aa) |
| | ZGRF1 | Zinc finger GRF-type containing 1. (2109 aa) |
| | KHDC3L | KH domain containing 3 like, subcortical maternal complex member. (229 aa) |
| | OOEP | Oocyte expressed protein. (149 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa) |
| | CCDC88A | Coiled-coil domain containing 88A. (1797 aa) |
| | POLA1 | DNA polymerase. (1465 aa) |
| | TRAIP | TRAF interacting protein. (469 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1273 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1243 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1104 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (425 aa) |
| | ETAA1 | ETAA1 activator of ATR kinase. (898 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | FANCM | FA complementation group M. (2050 aa) |
| | DTL | Denticleless E3 ubiquitin protein ligase homolog. (730 aa) |
| | POLK | DNA polymerase kappa. (847 aa) |
| | RTF2 | Replication termination factor 2. (306 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3128 aa) |
| | BAZ1A | Bromodomain adjacent to zinc finger domain 1A. (1558 aa) |
| | RBMS1 | RNA binding motif single stranded interacting protein 1. (406 aa) |
| | POLN | DNA polymerase nu. (663 aa) |
| | WRN | WRN RecQ like helicase. (1399 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (117 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | SDE2 | SDE2 telomere maintenance homolog. (451 aa) |
| | BOD1L1 | Biorientation of chromosomes in cell division 1 like 1. (2995 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (1016 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1406 aa) |
| | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa) |
| | RFC1 | Replication factor C subunit 1. (985 aa) |
| | BLM | BLM RecQ like helicase. (1423 aa) |
| | TICRR | TOPBP1 interacting checkpoint and replication regulator. (1911 aa) |
| | POLG | DNA polymerase gamma, catalytic subunit. (1228 aa) |
| | ORC3 | Origin recognition complex subunit 3. (711 aa) |
| | THOC1 | THO complex 1. (657 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (897 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3420 aa) |
| | LRWD1 | Leucine rich repeats and WD repeat domain containing 1. (647 aa) |
| | POLI | DNA polymerase iota. (672 aa) |
| | RFC2 | Replication factor C subunit 2. (353 aa) |
| | ENSCSAP00000014428 | Uncharacterized protein. (370 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | ENSCSAP00000014778 | RPA_C domain-containing protein. (256 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | PRIMPOL | Primase and DNA directed polymerase. (556 aa) |
| | LIG1 | DNA ligase. (919 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (551 aa) |
| | GRWD1 | Glutamate rich WD repeat containing 1. (446 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa) |
| | ZPR1 | ZPR1 zinc finger. (459 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (521 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (383 aa) |
| | DTD1 | D-aminoacyl-tRNA deacylase. (234 aa) |
| | SRPK2 | SRSF protein kinase 2. (702 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (342 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | CDC45 | Cell division cycle 45. (566 aa) |
| | DNAJC2 | DnaJ heat shock protein family (Hsp40) member C2. (621 aa) |
| | RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (976 aa) |
| | POLH | DNA polymerase eta. (712 aa) |
| | DBF4 | DBF4 zinc finger. (675 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | PCLAF | Uncharacterized protein. (111 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (383 aa) |
| | WDR18 | WD repeat domain 18. (432 aa) |
| | DHX9 | DExH-box helicase 9. (1126 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa) |
| | RBM48 | RNA binding motif protein 48. (367 aa) |
| | RPAIN | RPA interacting protein. (219 aa) |
| | CDC34 | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (236 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (808 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (636 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (307 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (874 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa) |
| | KIN | Kin17 DNA and RNA binding protein. (393 aa) |
| | FBH1 | F-box DNA helicase 1. (971 aa) |
| | CDK9 | Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (488 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa) |
| | TTC38 | Tetratricopeptide repeat domain 38. (475 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1118 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa) |
| | TIMELESS | Timeless circadian regulator. (1208 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (416 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (640 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (774 aa) |
| | HELB | DNA helicase B. (1087 aa) |
| | CHTF8 | Chromosome transmission fidelity factor 8. (121 aa) |
| | TBRG1 | Transforming growth factor beta regulator 1. (411 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | CHEK1 | Checkpoint kinase 1. (749 aa) |
| | ALYREF | Aly/REF export factor. (264 aa) |
| | SIRT7 | Sirtuin 7. (400 aa) |
| | POLD1 | DNA polymerase. (1086 aa) |
| | ENSCSAP00000015863 | Uncharacterized protein. (81 aa) |
| | CDK2AP1 | Cyclin-dependent kinase 2-associated protein; Belongs to the CDK2AP family. (114 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2288 aa) |
| | NFIA | Uncharacterized protein. (253 aa) |
| | ENSCSAP00000016684 | CTF/NF-I domain-containing protein. (231 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa) |
| | NASP | Nuclear autoantigenic sperm protein. (463 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | CORT | Cortistatin. (105 aa) |
| | CENPS | Centromere protein S. (138 aa) |
| | ZNF830 | Zinc finger protein 830. (372 aa) |
| | ENSCSAP00000017472 | ERCC4 domain-containing protein. (551 aa) |
| | PURA | Purine rich element binding protein A. (322 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | DDX11 | DEAD/H-box helicase 11. (906 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (777 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | DNAJA3 | DnaJ heat shock protein family (Hsp40) member A3. (479 aa) |
| | NFIB | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa) |
| | STRA8 | Stimulated by retinoic acid 8. (337 aa) |
| | TOP1MT | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (618 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (949 aa) |
| | ENSCSAP00000005289 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (398 aa) |
| | GMNC | Geminin coiled-coil domain containing. (334 aa) |
| | CHAF1B | Chromatin assembly factor 1 subunit B. (559 aa) |
| | TM4SF19 | Uncharacterized protein. (209 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (738 aa) |
| | NT5M | 5',3'-nucleotidase, mitochondrial. (228 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1377 aa) |
| | NRM | Nurim. (262 aa) |
| | RECQL4 | RecQ like helicase 4. (1210 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | SSBP1 | Single stranded DNA binding protein 1. (148 aa) |
| | RECQL | RecQ like helicase. (649 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (907 aa) |
| | GMNN | Geminin DNA replication inhibitor. (209 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | HMGA1 | High mobility group AT-hook 1. (107 aa) |
| | ENSCSAP00000003991 | Uncharacterized protein. (851 aa) |
| | DDX50 | DExD-box helicase 50. (737 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (665 aa) |
| | POLQ | DNA polymerase theta. (2729 aa) |
| | RRM2 | Ribonucleotide reductase regulatory subunit M2. (390 aa) |
| | RNASEH1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (286 aa) |
| | REPIN1 | Replication initiator 1. (624 aa) |
| | RBBP6 | RB binding protein 6, ubiquitin ligase. (1792 aa) |
| | RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (300 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1838 aa) |
| | NFIX | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (494 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (346 aa) |
| | LIG3 | DNA ligase. (1009 aa) |
| | DDX23 | DEAD-box helicase 23. (820 aa) |
| | NOC3L | Nucleolar complex protein 3 homolog. (800 aa) |
| | FAM111A | Family with sequence similarity 111 member A. (699 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa) |
| | ING5 | Inhibitor of growth protein. (240 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | TWNK | Twinkle mtDNA helicase. (684 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | DONSON | Downstream neighbor of SON. (564 aa) |
| | SLX4 | Uncharacterized protein. (929 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (626 aa) |
| | CINP | Cyclin dependent kinase 2 interacting protein. (212 aa) |
| | ENSCSAP00000006557 | Uncharacterized protein. (314 aa) |
| | ING4 | Inhibitor of growth protein. (249 aa) |
| | GINS1 | GINS complex subunit 1. (285 aa) |
| | DUT | Deoxyuridine triphosphatase. (252 aa) |
| | CHAF1A | Chromatin assembly factor 1 subunit A. (939 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (399 aa) |
| | ATRX | ATRX chromatin remodeler. (2459 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | E4F1 | E4F transcription factor 1. (784 aa) |
| | SETMAR | SET domain and mariner transposase fusion gene. (684 aa) |
| | NFIC | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (508 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa) |
