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| | ENSCSAP00000000080 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (199 aa) |
| | UVRAG | UV radiation resistance associated. (699 aa) |
| | RNF169 | Ring finger protein 169. (486 aa) |
| | GGN | Gametogenetin. (679 aa) |
| | SMARCAD1 | Uncharacterized protein. (840 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (409 aa) |
| | HELQ | Helicase, POLQ like. (1101 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (774 aa) |
| | ATP23 | Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (246 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (383 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa) |
| | DCLRE1A | DNA cross-link repair 1A. (1040 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (449 aa) |
| | NABP2 | Nucleic acid binding protein 2. (211 aa) |
| | SFR1 | SWI5 dependent homologous recombination repair protein 1. (232 aa) |
| | MBTD1 | Mbt domain containing 1. (690 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (615 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (329 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (609 aa) |
| | RAD51C | RAD51 paralog C. (367 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1248 aa) |
| | TNKS1BP1 | Tankyrase 1 binding protein 1. (1729 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (550 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | PRPF19 | Pre-mRNA processing factor 19. (504 aa) |
| | LIG3 | DNA ligase. (1009 aa) |
| | C19orf57 | Chromosome 19 open reading frame 57. (668 aa) |
| | ENSCSAP00000002816 | MPN domain-containing protein. (320 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1183 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1016 aa) |
| | SWSAP1 | SWIM-type zinc finger 7 associated protein 1. (229 aa) |
| | POLQ | DNA polymerase theta. (2729 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (818 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (739 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1061 aa) |
| | CDCA5 | Cell division cycle associated 5. (249 aa) |
| | INO80 | INO80 complex ATPase subunit. (1556 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (358 aa) |
| | DDX1 | DEAD-box helicase 1. (740 aa) |
| | RAD51AP2 | RAD51 associated protein 2. (1161 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1036 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (907 aa) |
| | HSF2BP | Heat shock transcription factor 2 binding protein. (334 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (522 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1000 aa) |
| | MARF1 | Meiosis regulator and mRNA stability factor 1. (1742 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (735 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | RECQL4 | RecQ like helicase 4. (1210 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1377 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (299 aa) |
| | SMC5 | SMC_N domain-containing protein. (1101 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (738 aa) |
| | KDM2A | Lysine demethylase 2A. (1145 aa) |
| | ZSWIM7 | Zinc finger SWIM-type containing 7. (140 aa) |
| | TM4SF19 | Uncharacterized protein. (209 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa) |
| | HMCES | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (949 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (718 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1977 aa) |
| | CYREN | Cell cycle regulator of NHEJ. (159 aa) |
| | MTA1 | Metastasis associated 1. (714 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (346 aa) |
| | SLX4 | Uncharacterized protein. (929 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (626 aa) |
| | ENSCSAP00000006204 | FHA domain-containing protein. (214 aa) |
| | CHEK2 | Protein kinase domain-containing protein. (318 aa) |
| | FANCD2 | Uncharacterized protein. (1458 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (246 aa) |
| | VCP | Valosin containing protein; Belongs to the AAA ATPase family. (806 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (415 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1494 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (485 aa) |
| | IFFO1 | Intermediate filament family orphan 1; Belongs to the intermediate filament family. (564 aa) |
| | RAD21L1 | RAD21 cohesin complex component like 1. (556 aa) |
| | SIRT6 | Sirtuin 6. (355 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (584 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (501 aa) |
| | ENSCSAP00000007123 | RAD51_interact domain-containing protein. (319 aa) |
| | RAD21 | RAD21 cohesin complex component. (631 aa) |
| | SETMAR | SET domain and mariner transposase fusion gene. (684 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (354 aa) |
| | MEIOB | Meiosis specific with OB-fold. (472 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (383 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (463 aa) |
| | ENSCSAP00000007698 | MPN domain-containing protein. (285 aa) |
| | EPC1 | Enhancer of polycomb homolog. (813 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (411 aa) |
| | CDC45 | Cell division cycle 45. (566 aa) |
| | NABP1 | Nucleic acid binding protein 1. (204 aa) |
| | INIP | INTS3 and NABP interacting protein. (104 aa) |
| | RAD54B | Uncharacterized protein. (908 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (200 aa) |
| | SEM1 | SEM1 26S proteasome complex subunit. (123 aa) |
| | SEM1-2 | Uncharacterized protein. (70 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (636 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | RAD51B | RAD51 paralog B. (265 aa) |
| | ZFYVE26 | Zinc finger FYVE-type containing 26. (2539 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa) |
| | FBH1 | F-box DNA helicase 1. (971 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (586 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (557 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (515 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (532 aa) |
| | SWI5 | SWI5 homologous recombination repair protein. (164 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (681 aa) |
| | MLH1 | MutL homolog 1. (756 aa) |
| | C14orf39 | Chromosome 14 open reading frame 39. (589 aa) |
| | POLA1 | DNA polymerase. (1465 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1243 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa) |
| | WDR48 | WD repeat domain 48. (677 aa) |
| | ENSCSAP00000010913 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4131 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (939 aa) |
| | APLF | Aprataxin and PNKP like factor. (511 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (334 aa) |
| | SETX | Senataxin. (2679 aa) |
| | FANCB | FA complementation group B. (859 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | FANCM | FA complementation group M. (2050 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (397 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3128 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | POLN | DNA polymerase nu. (663 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | WRN | WRN RecQ like helicase. (1399 aa) |
| | ESCO2 | Establishment of sister chromatid cohesion N-acetyltransferase 2. (600 aa) |
| | REC8 | REC8 meiotic recombination protein. (517 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1142 aa) |
| | PAXX | PAXX non-homologous end joining factor. (204 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | PARP1 | Poly(ADP-ribose) polymerase 1. (709 aa) |
| | PARP2 | Poly(ADP-ribose) polymerase 2. (570 aa) |
| | NIPBL | Nipped-B protein. (2804 aa) |
| | BLM | BLM RecQ like helicase. (1423 aa) |
| | PRDM9 | Uncharacterized protein. (691 aa) |
| | TENT4A | Terminal nucleotidyltransferase 4A. (542 aa) |
| | TRIP13 | Thyroid hormone receptor interactor 13. (432 aa) |
| | BIVM | Basic, immunoglobulin-like variable motif containing. (503 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (2005 aa) |
| | AP5Z1 | Adaptor related protein complex 5 subunit zeta 1. (808 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (897 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3420 aa) |
| | MEIOC | Meiosis specific with coiled-coil domain. (955 aa) |
| | BRCA1 | Uncharacterized protein. (663 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | ENSCSAP00000014778 | RPA_C domain-containing protein. (256 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | HPF1 | Histone PARylation factor 1. (346 aa) |
| | PPP5C | Serine/threonine-protein phosphatase. (499 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (563 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (521 aa) |
| | INTS3 | Integrator complex subunit 3. (798 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (532 aa) |
| | CDC7 | Cell division cycle 7. (576 aa) |
| | RAD54L | RAD54 like. (747 aa) |
| | SLFNL1 | Schlafen like 1. (407 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (708 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (351 aa) |
| | IFFO2 | Intermediate filament family orphan 2; Belongs to the intermediate filament family. (287 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | ENSCSAP00000017472 | ERCC4 domain-containing protein. (551 aa) |
| | UBE2NL | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | LOC103222584 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | NSMCE3 | NSE3 homolog, SMC5-SMC6 complex component. (304 aa) |
