STRINGSTRING
DDB1 DDB1 TRIM21 TRIM21 CTR9 CTR9 UBE2O UBE2O TSG101 TSG101 NEURL1 NEURL1 PCGF6 PCGF6 RAG1 RAG1 TRIM56 TRIM56 FANCF FANCF LOC103214510 LOC103214510 ENSCSAP00000017299 ENSCSAP00000017299 ENSCSAP00000016815 ENSCSAP00000016815 KDM2B KDM2B CBL CBL PCGF2 PCGF2 FANCA FANCA ATXN7L3 ATXN7L3 CUL4B CUL4B BRCA2 BRCA2 OBI1 OBI1 MARCHF7 MARCHF7 PCGF1 PCGF1 DTL DTL PCGF3 PCGF3 FANCB FANCB FANCL FANCL KLHL12 KLHL12 UBE2T UBE2T BCOR BCOR SKP1 SKP1 ENSCSAP00000009681 ENSCSAP00000009681 CDC73 CDC73 RNF2 RNF2 ENSCSAP00000008966 ENSCSAP00000008966 HUWE1 HUWE1 BMI1 BMI1 KLHL22 KLHL22 PRKN PRKN ZC4H2 ZC4H2 WAC WAC KBTBD8 KBTBD8 RYBP RYBP LEO1 LEO1 RNF20 RNF20 ZNF598 ZNF598 RAD18 RAD18 UHRF1 UHRF1 FANCG FANCG UBE2R2 UBE2R2 FANCE FANCE TOPORS TOPORS UBE2E1 UBE2E1 RING1 RING1 FBXL2 FBXL2 BARD1 BARD1 MGRN1 MGRN1 RNF168 RNF168 TRIM41 TRIM41 CUL3 CUL3 RAD51 RAD51 DTX3L DTX3L CUL1 CUL1 PCGF5 PCGF5 ENSCSAP00000002816 ENSCSAP00000002816 FANCC FANCC PEX12 PEX12 RBX1 RBX1 TRIM37 TRIM37 RNF40 RNF40 DDB2 DDB2 TRIM25 TRIM25
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDB1Damage specific DNA binding protein 1. (1140 aa)
TRIM21Tripartite motif containing 21. (475 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1293 aa)
TSG101Tumor susceptibility 101. (390 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
PCGF6Polycomb group ring finger 6. (350 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (953 aa)
TRIM56Tripartite motif containing 56. (755 aa)
FANCFFA complementation group F. (374 aa)
LOC103214510RING-type domain-containing protein. (311 aa)
ENSCSAP00000017299Uncharacterized protein. (179 aa)
ENSCSAP00000016815RING-type domain-containing protein. (282 aa)
KDM2BLysine demethylase 2B. (1348 aa)
CBLCbl proto-oncogene. (907 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
FANCAFA complementation group A. (1455 aa)
ATXN7L3Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] (400 aa)
CUL4BCullin 4B; Belongs to the cullin family. (900 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
OBI1ORC ubiquitin ligase 1. (726 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (697 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
PCGF3Polycomb group ring finger 3. (242 aa)
FANCBFA complementation group B. (859 aa)
FANCLFA complementation group L. (461 aa)
KLHL12BTB domain-containing protein. (527 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (197 aa)
BCORBCL6 corepressor. (1721 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
ENSCSAP00000009681UBIQUITIN_CONJUGAT_2 domain-containing protein. (151 aa)
CDC73Cell division cycle 73. (531 aa)
RNF2Ring finger protein 2. (336 aa)
ENSCSAP00000008966RING-type domain-containing protein. (323 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4374 aa)
BMI1RING-type domain-containing protein. (449 aa)
KLHL22Kelch like family member 22. (634 aa)
PRKNParkin RBR E3 ubiquitin protein ligase. (288 aa)
ZC4H2Zinc finger C4H2-type containing. (224 aa)
WACWW domain containing adaptor with coiled-coil. (647 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (575 aa)
RYBPRING1 and YY1 binding protein. (228 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
ZNF598Zinc finger protein 598. (909 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (505 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (801 aa)
FANCGFA complementation group G. (622 aa)
UBE2R2Ubiquitin conjugating enzyme E2 R2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
FANCEFA complementation group E. (323 aa)
TOPORSTOP1 binding arginine/serine rich protein. (1044 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
RING1Ring finger protein 1. (406 aa)
FBXL2F-box and leucine rich repeat protein 2. (423 aa)
BARD1BRCA1 associated RING domain 1. (777 aa)
MGRN1Mahogunin ring finger 1. (576 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
TRIM41Tripartite motif containing 41. (517 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (739 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
PCGF5Polycomb group ring finger 5. (256 aa)
ENSCSAP00000002816MPN domain-containing protein. (320 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (559 aa)
PEX12Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family. (359 aa)
RBX1Ring-box 1. (108 aa)
TRIM37Tripartite motif containing 37. (963 aa)
RNF40E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1001 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
TRIM25Tripartite motif containing 25. (630 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (18%) [HD]