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CACNG7 CACNG7 CACNG8 CACNG8 ENSCSAP00000016198 ENSCSAP00000016198 LILRB4 LILRB4 FNBP1L FNBP1L BTBD8 BTBD8 SGIP1 SGIP1 DNAJC6 DNAJC6 EPS15 EPS15 PPT1 PPT1 CAP1 CAP1 LDLRAP1 LDLRAP1 HSPG2 HSPG2 HTR1B HTR1B ENSCSAP00000018099 ENSCSAP00000018099 CXCR1 CXCR1 ACKR3 ACKR3 LRRTM1 LRRTM1 ADRB2 ADRB2 AP2B1 AP2B1 CLN3 CLN3 CLEC17A CLEC17A SLC9B2 SLC9B2 ARHGAP27 ARHGAP27 PICALM PICALM GRK3 GRK3 AMN AMN PIKFYVE PIKFYVE ITSN1 ITSN1 CALY CALY FCHSD2 FCHSD2 SYK SYK HTR2B HTR2B LDLR LDLR MICALL1 MICALL1 DRD3 DRD3 ENSCSAP00000014296 ENSCSAP00000014296 DNM2 DNM2 LRP6 LRP6 TFRC TFRC GRK2 GRK2 ITSN2 ITSN2 CANX CANX CACNG2 CACNG2 ITGB2 ITGB2 CTSL CTSL SAG SAG RABGEF1 RABGEF1 HIP1 HIP1 LOC103247163 LOC103247163 AP1S1 AP1S1 ACHE ACHE TFR2 TFR2 MICALL2 MICALL2 RAB31 RAB31 REPS1 REPS1 DAB2 DAB2 MSR1 MSR1 LRP1B LRP1B AP1G2 AP1G2 GRK4 GRK4 RAMP3 RAMP3 PLA2R1 PLA2R1 DPP4 DPP4 FCHO2 FCHO2 DBNL DBNL WASF1 WASF1 GAK GAK LRP2 LRP2 GPR107 GPR107 CNTN2 CNTN2 CLHC1 CLHC1 DNM1 DNM1 SCARF1 SCARF1 SNAP25 SNAP25 AP2M1 AP2M1 LMBRD1 LMBRD1 STAB1 STAB1 SNX9 SNX9 CXCL16 CXCL16 SIGLEC1 SIGLEC1 ITGA4 ITGA4 CD14 CD14 CUBN CUBN EZR EZR MRC1 MRC1 CALCRL CALCRL SNX1 SNX1 IGF2R IGF2R RNASEK RNASEK CD36 CD36 ENSCSAP00000008056 ENSCSAP00000008056 DLL1 DLL1 NEDD4 NEDD4 DNM3 DNM3 ARR3 ARR3 CLTCL1 CLTCL1 ITGB1 ITGB1 AP4E1 AP4E1 PIP5K1C PIP5K1C CAV1 CAV1 GRIA1 GRIA1 CAV3 CAV3 CD9 CD9 CLTA CLTA TMEM108 TMEM108 DNAJC13 DNAJC13 AP2A2 AP2A2 LMBR1L LMBR1L RAMP1 RAMP1 CLTC CLTC ITGAM ITGAM FCHO1 FCHO1 LDLRAD3 LDLRAD3 VLDLR VLDLR PDLIM7 PDLIM7 CLEC9A CLEC9A TPCN2 TPCN2 CLTB CLTB CTTN CTTN M6PR M6PR TGFBR2 TGFBR2 CD81 CD81 LRP1 LRP1 CXCL8 CXCL8 GRB2 GRB2 CALCA CALCA INPP5F INPP5F LRP3 LRP3 SCARB2 SCARB2 ENSCSAP00000000932 ENSCSAP00000000932 ADM ADM CACNG4 CACNG4 CACNG5 CACNG5 SCYL2 SCYL2 CEACAM1 CEACAM1 RAMP2 RAMP2 APOE APOE STAB2 STAB2 FCER1G FCER1G ENSCSAP00000015592 ENSCSAP00000015592 AP2A1 AP2A1 SORL1 SORL1 HGS HGS HIP1R HIP1R
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (421 aa)
ENSCSAP00000016198Uncharacterized protein. (710 aa)
LILRB4Leukocyte immunoglobulin like receptor B4. (448 aa)
FNBP1LFormin binding protein 1 like. (547 aa)
BTBD8BTB domain containing 8. (1356 aa)
SGIP1SH3 domain GRB2 like endophilin interacting protein 1. (828 aa)
DNAJC6DnaJ heat shock protein family (Hsp40) member C6. (913 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (897 aa)
PPT1Palmitoyl-protein thioesterase 1. (306 aa)
CAP1Adenylyl cyclase-associated protein; Belongs to the CAP family. (475 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (320 aa)
HSPG2Heparan sulfate proteoglycan 2. (4391 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
ENSCSAP00000018099Uncharacterized protein. (491 aa)
CXCR1C-X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
LRRTM1Leucine rich repeat transmembrane neuronal 1. (522 aa)
ADRB2Adrenoceptor beta 2. (415 aa)
AP2B1AP complex subunit beta. (951 aa)
CLN3Battenin. (438 aa)
CLEC17AC-type lectin domain containing 17A. (379 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
ARHGAP27Rho GTPase activating protein 27. (887 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (660 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
AMNAmnion associated transmembrane protein. (484 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2098 aa)
ITSN1Intersectin 1. (1649 aa)
CALYCalcyon neuron specific vesicular protein. (217 aa)
FCHSD2FCH and double SH3 domains 2. (740 aa)
SYKTyrosine-protein kinase. (635 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
LDLRLow density lipoprotein receptor. (767 aa)
MICALL1MICAL like 1. (863 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (403 aa)
ENSCSAP00000014296VPS9 domain-containing protein. (512 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
TFRCTransferrin receptor. (774 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
ITSN2Intersectin 2. (1684 aa)
CANXCalnexin. (610 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
ITGB2Integrin beta. (784 aa)
CTSLCathepsin L; Belongs to the peptidase C1 family. (333 aa)
SAGS-antigen visual arrestin. (405 aa)
RABGEF1Uncharacterized protein. (506 aa)
HIP1Huntingtin interacting protein 1. (1003 aa)
LOC103247163Uncharacterized protein. (357 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (614 aa)
TFR2Transferrin receptor 2. (798 aa)
MICALL2MICAL like 2. (908 aa)
RAB31RAB31, member RAS oncogene family. (194 aa)
REPS1RALBP1 associated Eps domain containing 1. (796 aa)
DAB2DAB adaptor protein 2. (770 aa)
MSR1Macrophage scavenger receptor 1. (451 aa)
LRP1BLDL receptor related protein 1B. (4417 aa)
AP1G2AP-1 complex subunit gamma. (785 aa)
GRK4G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (572 aa)
RAMP3Receptor activity modifying protein 3. (201 aa)
PLA2R1Phospholipase A2 receptor 1. (1392 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (766 aa)
FCHO2FCH domain only 2. (811 aa)
DBNLDrebrin like. (436 aa)
WASF1WASP family member 1. (559 aa)
GAKCyclin G associated kinase. (1311 aa)
LRP2LDL receptor related protein 2. (3861 aa)
GPR107G protein-coupled receptor 107. (552 aa)
CNTN2Contactin 2. (1040 aa)
CLHC1Clathrin heavy chain linker domain-containing protein 1. (586 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (775 aa)
SCARF1Scavenger receptor class F member 1. (834 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
AP2M1Adaptor related protein complex 2 subunit mu 1; Belongs to the adaptor complexes medium subunit family. (251 aa)
LMBRD1LMBR1 domain containing 1. (540 aa)
STAB1Stabilin 1. (2189 aa)
SNX9Sorting nexin. (618 aa)
CXCL16C-X-C motif chemokine ligand 16. (275 aa)
SIGLEC1Sialic acid binding Ig like lectin 1. (1702 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
CUBNCubilin. (3623 aa)
EZREzrin. (584 aa)
MRC1Mannose receptor C-type 1. (1456 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (472 aa)
SNX1Sorting nexin 1. (522 aa)
IGF2RInsulin like growth factor 2 receptor. (2491 aa)
RNASEKRibonuclease K. (137 aa)
CD36CD36 molecule; Belongs to the CD36 family. (473 aa)
ENSCSAP00000008056Uncharacterized protein. (534 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
NEDD4E3 ubiquitin-protein ligase. (900 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
ARR3Arrestin 3. (401 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1914 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
AP4E1AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (1137 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (668 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (811 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
CD9Tetraspanin. (228 aa)
CLTAClathrin light chain A. (218 aa)
TMEM108Transmembrane protein 108. (575 aa)
DNAJC13DnaJ heat shock protein family (Hsp40) member C13. (2248 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (939 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (489 aa)
RAMP1Receptor activity modifying protein 1. (148 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1495 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1151 aa)
FCHO1FCH domain only 1. (810 aa)
LDLRAD3Low density lipoprotein receptor class A domain containing 3. (345 aa)
VLDLRVery low density lipoprotein receptor. (873 aa)
PDLIM7PDZ and LIM domain 7. (423 aa)
CLEC9AC-type lectin domain containing 9A. (241 aa)
TPCN2Two pore segment channel 2. (752 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (211 aa)
CTTNCortactin. (550 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (278 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
CD81Tetraspanin. (236 aa)
LRP1LDL receptor related protein 1. (4544 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
INPP5FInositol polyphosphate-5-phosphatase F. (1133 aa)
LRP3LDL receptor related protein 3. (770 aa)
SCARB2Scavenger receptor class B member 2; Belongs to the CD36 family. (478 aa)
ENSCSAP00000000932Uncharacterized protein. (1067 aa)
ADMAdrenomedullin. (185 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (278 aa)
SCYL2Uncharacterized protein. (609 aa)
CEACAM1Uncharacterized protein. (525 aa)
RAMP2Receptor activity modifying protein 2. (175 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
STAB2Stabilin 2. (2559 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
ENSCSAP00000015592Adaptin_N domain-containing protein. (132 aa)
AP2A1Alpha_adaptinC2 domain-containing protein. (817 aa)
SORL1Sortilin related receptor 1. (2214 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
HIP1RHuntingtin interacting protein 1 related. (1056 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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