STRINGSTRING
FBXW9 FBXW9 PERP PERP RBPJ RBPJ PSEN2 PSEN2 HEY2 HEY2 NOTCH1 NOTCH1 NFKBIA NFKBIA PGAM2 PGAM2 FOXA1 FOXA1 SNAI1 SNAI1 ANXA4 ANXA4 SNAI2 SNAI2 DLX1 DLX1 DLX2 DLX2 HOXD3 HOXD3 JAG1 JAG1 BMP2 BMP2 HEY1 HEY1 IL17A IL17A PSEN1 PSEN1 CFD CFD POFUT1 POFUT1 CDK6 CDK6 CFAP58 CFAP58 NEURL1 NEURL1 ZNF423 ZNF423 TBX2 TBX2 DTX4 DTX4 HNF1B HNF1B NOTCH3 NOTCH3 NLE1 NLE1 GALNT11 GALNT11 MESP2 MESP2 MECP2 MECP2 DNER DNER ITGB1BP1 ITGB1BP1 CNTN1 CNTN1 ADAM17 ADAM17 GMDS GMDS DTX3L DTX3L TSPEAR TSPEAR DLL4 DLL4 CHAC1 CHAC1 MAML1 MAML1 CDKN1B CDKN1B TP63 TP63 APP APP GRIP2 GRIP2 NOTCH4 NOTCH4 SUSD5 SUSD5 PTP4A3 PTP4A3 JAG2 JAG2 NEURL1B NEURL1B TGFBR2 TGFBR2 IFT74 IFT74 APH1B APH1B ADAM10 ADAM10 DLL1 DLL1 SEL1L SEL1L NRIP2 NRIP2 CNTN6 CNTN6 TRAF7 TRAF7 HES7 HES7 ANGPT4 ANGPT4 TIMP4 TIMP4 NRARP NRARP KCNA5 KCNA5 FOXC1 FOXC1 PLN PLN ASCL1 ASCL1 CEBPA CEBPA S1PR3 S1PR3 FOXC2 FOXC2 ATOH1 ATOH1 TMEM100 TMEM100 MIB2 MIB2 HES5 HES5 HES3 HES3 SPEN SPEN NR0B2 NR0B2 HEYL HEYL RBM15 RBM15 EPN1 EPN1 NOTCH2 NOTCH2 RITA1 RITA1 DTX1 DTX1 NCSTN NCSTN ETV2 ETV2 PSENEN PSENEN DLL3 DLL3 SORBS2 SORBS2 KRT19 KRT19 MAML2 MAML2 FBXW7 FBXW7 NR1H4 NR1H4 MAML3 MAML3 TGFB1 TGFB1 DTX2 DTX2 APH1A APH1A MIB1 MIB1 RIPPLY2 RIPPLY2 CDH6 CDH6 MESP1 MESP1 GSX2 GSX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FBXW9F-box and WD repeat domain containing 9. (458 aa)
PERPP53 apoptosis effector related to PMP22. (193 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (357 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
NOTCH1Notch receptor 1. (2555 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
FOXA1Forkhead box A1. (470 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
ANXA4Annexin. (321 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
DLX1Distal-less homeobox 1. (255 aa)
DLX2Distal-less homeobox 2. (329 aa)
HOXD3Homeobox D3. (432 aa)
JAG1Jagged canonical Notch ligand 1. (1218 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
IL17AInterleukin 17A. (155 aa)
PSEN1Presenilin 1. (467 aa)
CFDComplement factor D; Belongs to the peptidase S1 family. (253 aa)
POFUT1Protein O-fucosyltransferase 1. (365 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CFAP58Cilia and flagella associated protein 58. (823 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (574 aa)
ZNF423Zinc finger protein 423. (1284 aa)
TBX2T-box transcription factor 2. (588 aa)
DTX4Deltex E3 ubiquitin ligase 4. (619 aa)
HNF1BHNF1 homeobox B. (557 aa)
NOTCH3Notch receptor 3. (1980 aa)
NLE1Notchless homolog 1. (487 aa)
GALNT11Polypeptide N-acetylgalactosaminyltransferase. (607 aa)
MESP2Uncharacterized protein. (205 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (479 aa)
DNERDelta/notch like EGF repeat containing. (590 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
CNTN1Contactin 1. (1018 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
GMDSNAD(P)-bd_dom domain-containing protein. (195 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (739 aa)
TSPEARThrombospondin type laminin G domain and EAR repeats. (644 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (222 aa)
MAML1Mastermind like transcriptional coactivator 1. (790 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (500 aa)
APPAmyloid beta precursor protein. (770 aa)
GRIP2Glutamate receptor interacting protein 2. (1048 aa)
NOTCH4Notch receptor 4. (1994 aa)
SUSD5Sushi domain containing 5. (519 aa)
PTP4A3Protein tyrosine phosphatase 4A3. (173 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1245 aa)
NEURL1BNeuralized E3 ubiquitin protein ligase 1B. (555 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
IFT74Intraflagellar transport 74. (600 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
SEL1LSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (794 aa)
NRIP2Nuclear receptor interacting protein 2. (278 aa)
CNTN6Contactin 6. (1030 aa)
TRAF7TNF receptor associated factor 7. (670 aa)
HES7Hes family bHLH transcription factor 7. (230 aa)
ANGPT4Angiopoietin 4. (503 aa)
TIMP4TIMP metallopeptidase inhibitor 4. (224 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
FOXC1Forkhead box C1. (552 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (239 aa)
CEBPACCAAT enhancer binding protein alpha. (356 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
FOXC2Forkhead box C2. (501 aa)
ATOH1Atonal bHLH transcription factor 1. (354 aa)
TMEM100Transmembrane protein 100. (134 aa)
MIB2Mindbomb E3 ubiquitin protein ligase 2. (955 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
HES3Hes family bHLH transcription factor 3. (197 aa)
SPENSpen family transcriptional repressor. (3670 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
RBM15RNA binding motif protein 15. (976 aa)
EPN1Epsin 1. (576 aa)
NOTCH2Notch receptor 2. (2471 aa)
RITA1RBPJ interacting and tubulin associated 1. (293 aa)
DTX1Deltex E3 ubiquitin ligase 1. (624 aa)
NCSTNNicastrin. (709 aa)
ETV2ETS variant 2. (375 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
DLL3Delta like canonical Notch ligand 3. (614 aa)
SORBS2Sorbin and SH3 domain containing 2. (1524 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (400 aa)
MAML2Mastermind like transcriptional coactivator 2. (923 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (476 aa)
MAML3Mastermind like transcriptional coactivator 3. (982 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
DTX2Deltex E3 ubiquitin ligase 2. (622 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
RIPPLY2Ripply transcriptional repressor 2. (128 aa)
CDH6Cadherin 6; Cadherins are calcium-dependent cell adhesion proteins. (790 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
GSX2GS homeobox 2. (304 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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