STRINGSTRING
SNF8 SNF8 PHB PHB BAIAP2 BAIAP2 SHANK1 SHANK1 PIAS3 PIAS3 TAF13 TAF13 GPSM2 GPSM2 BCL10 BCL10 LOC103224612 LOC103224612 LRRC7 LRRC7 ITGB3BP ITGB3BP PATJ PATJ ENSCSAP00000016690 ENSCSAP00000016690 CDC20 CDC20 LCK LCK EPB41 EPB41 HSPG2 HSPG2 HSPB7 HSPB7 PEX10 PEX10 ENSCSAP00000017599 ENSCSAP00000017599 ENSCSAP00000017683 ENSCSAP00000017683 LIG4 LIG4 SDCBP SDCBP MID1IP1 MID1IP1 VGLL3 VGLL3 TFCP2 TFCP2 EP300 EP300 XRCC6 XRCC6 SREBF2 SREBF2 DGKZ DGKZ BLOC1S2 BLOC1S2 PEX16 PEX16 SP1 SP1 CALCOCO1 CALCOCO1 SIAH1 SIAH1 FBLN1 FBLN1 HOMER3 HOMER3 PPP1R9B PPP1R9B CEP135 CEP135 MIF4GD MIF4GD SHANK3 SHANK3 MKI67 MKI67 GRIP1 GRIP1 TRIM3 TRIM3 YEATS4 YEATS4 NUMA1 NUMA1 PTPRB PTPRB TERF2 TERF2 VPS4A VPS4A PLEKHB1 PLEKHB1 MAD2L1 MAD2L1 SIRT1 SIRT1 PEX1 PEX1 PXK PXK DLG4 DLG4 AFDN AFDN PABPC1 PABPC1 MAGI1 MAGI1 ARL6IP5 ARL6IP5 ENSCSAP00000007827 ENSCSAP00000007827 PDZD11 PDZD11 POLR2A POLR2A PEX6 PEX6 FOXN3 FOXN3 MED12 MED12 CITED1 CITED1 SLC9A3R2 SLC9A3R2 ATP1B1 ATP1B1 HRAS HRAS CAV3 CAV3 PIAS4 PIAS4 TOPBP1 TOPBP1 SDCBP2 SDCBP2 ERCC6 ERCC6 CEP250 CEP250 PHB2 PHB2 ATP2B2 ATP2B2 PEX5 PEX5 TOP2B TOP2B SYNJ1 SYNJ1 AGO2 AGO2 ENSCSAP00000005806 ENSCSAP00000005806 SCAF4 SCAF4 MAPRE3 MAPRE3 SHANK2 SHANK2 KCNK3 KCNK3 CATSPERE CATSPERE FN1 FN1 MPDZ MPDZ XRCC5 XRCC5 RBFOX1 RBFOX1 DLG1 DLG1 USP7 USP7 CIITA CIITA NCF2 NCF2 EZR EZR ID1 ID1 HESX1 HESX1 AXIN1 AXIN1 SYNJ2BP SYNJ2BP EFHC1 EFHC1 MAP2K1 MAP2K1 HIC2 HIC2 DST DST PCNA PCNA MSH2 MSH2 TAX1BP3 TAX1BP3 TERF1 TERF1 PPP2CA PPP2CA SRC SRC IFT52 IFT52 MYO1C MYO1C PEX26 PEX26 MDC1 MDC1 MAP2K7 MAP2K7 ERCC4 ERCC4 BANF1 BANF1 SPTBN5 SPTBN5 SDC1 SDC1 SIPA1 SIPA1 CSK CSK NEIL1 NEIL1 ENSCSAP00000010642 ENSCSAP00000010642 CEP120 CEP120 ABL1 ABL1 SNTG1 SNTG1 CNRIP1 CNRIP1 XRCC4 XRCC4 TBL1X TBL1X DBNL DBNL CENPF CENPF CTBP1 CTBP1 PCGF1 PCGF1 PPP2CB PPP2CB CDK7 CDK7 VGLL2 VGLL2 PTK2B PTK2B NEFL NEFL CCN2 CCN2 ERCC3 ERCC3 CACNA1B CACNA1B CTNNB1 CTNNB1 DAB2 DAB2 TNFAIP3 TNFAIP3 NIPBL NIPBL VTA1 VTA1 CIB1 CIB1 SASH1 SASH1 CNGA3 CNGA3 SH3GL3 SH3GL3 TERT TERT ENSCSAP00000013601 ENSCSAP00000013601 LMO7 LMO7 VPS36 VPS36 KPNA3 KPNA3 BRCA2 BRCA2 ECM1 ECM1 TCF4 TCF4 ATXN1 ATXN1 KSR1 KSR1 RAD51 RAD51 CD2AP CD2AP PICK1 PICK1 TJP1 TJP1 PAXIP1 PAXIP1 ATF4 ATF4 PFKM PFKM ENSCSAP00000002584 ENSCSAP00000002584 PEX12 PEX12 CORO1A CORO1A SCLT1 SCLT1 RABAC1 RABAC1 BCAM BCAM YAP1 YAP1 ERCC2 ERCC2 ERCC1 ERCC1 SAE1 SAE1 NPAT NPAT TOP2A TOP2A ZBTB16 ZBTB16 ERBB2 ERBB2 ATP2A2 ATP2A2 PPP1CC PPP1CC ATXN2 ATXN2 IFT46 IFT46 PDZD3 PDZD3 MCAM MCAM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
PHBProhibitin. (272 aa)
BAIAP2BAI1 associated protein 2. (595 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (2173 aa)
PIAS3Protein inhibitor of activated STAT 3. (542 aa)
TAF13TATA-box binding protein associated factor 13. (124 aa)
GPSM2G protein signaling modulator 2. (685 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
LOC103224612Uncharacterized protein. (835 aa)
LRRC7Leucine rich repeat containing 7. (1358 aa)
ITGB3BPCentromere protein R; Transcription coregulator that can have both coactivator and corepressor functions. (177 aa)
PATJPATJ crumbs cell polarity complex component. (1802 aa)
ENSCSAP00000016690Prohibitin. (261 aa)
CDC20Cell division cycle 20. (499 aa)
LCKTyrosine-protein kinase. (513 aa)
EPB41Erythrocyte membrane protein band 4.1. (667 aa)
HSPG2Heparan sulfate proteoglycan 2. (4391 aa)
HSPB7Heat shock protein family B (small) member 7; Belongs to the small heat shock protein (HSP20) family. (170 aa)
PEX10Peroxisomal biogenesis factor 10. (326 aa)
ENSCSAP00000017599annotation not available (271 aa)
ENSCSAP00000017683Prohibitin. (272 aa)
LIG4DNA ligase. (911 aa)
SDCBPUncharacterized protein. (293 aa)
MID1IP1MID1 interacting protein 1. (183 aa)
VGLL3Vestigial like family member 3. (306 aa)
TFCP2Transcription factor CP2. (502 aa)
EP300E1A binding protein p300. (2416 aa)
XRCC6X-ray repair cross complementing 6. (609 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1144 aa)
DGKZDiacylglycerol kinase. (929 aa)
BLOC1S2Biogenesis of lysosomal organelles complex 1 subunit 2. (142 aa)
PEX16Peroxisomal membrane protein PEX16. (336 aa)
SP1Sp1 transcription factor. (786 aa)
CALCOCO1Calcium binding and coiled-coil domain 1. (691 aa)
SIAH1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (313 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (703 aa)
HOMER3WH1 domain-containing protein. (361 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (816 aa)
CEP135Centrosomal protein 135. (1140 aa)
MIF4GDMIF4G domain containing. (222 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1737 aa)
MKI67Marker of proliferation Ki-67. (3251 aa)
GRIP1Glutamate receptor interacting protein 1. (1113 aa)
TRIM3Tripartite motif containing 3. (744 aa)
YEATS4YEATS domain containing 4. (227 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2118 aa)
PTPRBProtein tyrosine phosphatase receptor type B. (2216 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (500 aa)
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (437 aa)
PLEKHB1Pleckstrin homology domain containing B1. (189 aa)
MAD2L1HORMA domain-containing protein. (75 aa)
SIRT1Sirtuin 1. (743 aa)
PEX1Peroxisomal biogenesis factor 1. (1283 aa)
PXKPX domain containing serine/threonine kinase like. (515 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (724 aa)
AFDNAfadin, adherens junction formation factor. (1843 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
MAGI1Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1349 aa)
ARL6IP5PRA1 family protein. (188 aa)
ENSCSAP00000007827Uncharacterized protein. (893 aa)
PDZD11PDZ domain-containing protein. (140 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1971 aa)
PEX6Peroxisomal biogenesis factor 6. (980 aa)
FOXN3Forkhead box N3. (368 aa)
MED12Mediator complex subunit 12. (2090 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
SLC9A3R2Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (337 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PIAS4Protein inhibitor of activated STAT 4. (501 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1527 aa)
SDCBP2Syndecan binding protein 2. (292 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1494 aa)
CEP250Centrosomal protein 250. (2441 aa)
PHB2Prohibitin. (288 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1199 aa)
PEX5Peroxisomal biogenesis factor 5. (639 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1621 aa)
SYNJ1Synaptojanin 1. (1311 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (904 aa)
ENSCSAP00000005806Fork-head domain-containing protein. (481 aa)
SCAF4SR-related CTD associated factor 4. (1151 aa)
MAPRE3Microtubule associated protein RP/EB family member 3. (281 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1163 aa)
KCNK3Potassium channel subfamily K member. (394 aa)
CATSPERECatsper channel auxiliary subunit epsilon. (950 aa)
FN1Fibronectin 1. (2265 aa)
MPDZMultiple PDZ domain crumbs cell polarity complex component. (2089 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
RBFOX1RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events. (376 aa)
DLG1Uncharacterized protein; Belongs to the MAGUK family. (800 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1102 aa)
CIITAClass II major histocompatibility complex transactivator. (1106 aa)
NCF2Neutrophil cytosolic factor 2. (526 aa)
EZREzrin. (584 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
HESX1HESX homeobox 1. (112 aa)
AXIN1Axin 1. (867 aa)
SYNJ2BPSynaptojanin 2 binding protein. (125 aa)
EFHC1EF-hand domain containing 1. (640 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
HIC2HIC ZBTB transcriptional repressor 2. (615 aa)
DSTDystonin. (5699 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
TAX1BP3Uncharacterized protein. (69 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (440 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SRCTyrosine-protein kinase. (633 aa)
IFT52Intraflagellar transport 52. (442 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1011 aa)
PEX26Peroxisomal biogenesis factor 26. (305 aa)
MDC1Mediator of DNA damage checkpoint 1. (1964 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (517 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (735 aa)
BANF1Barrier to autointegration factor 1. (89 aa)
SPTBN5Spectrin beta, non-erythrocytic 5. (3671 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
SIPA1Signal-induced proliferation-associated 1. (1042 aa)
CSKTyrosine-protein kinase. (450 aa)
NEIL1Nei like DNA glycosylase 1. (390 aa)
ENSCSAP00000010642Uncharacterized protein. (241 aa)
CEP120Centrosomal protein 120. (986 aa)
ABL1Tyrosine-protein kinase. (1130 aa)
SNTG1Syntrophin gamma 1. (269 aa)
CNRIP1Cannabinoid receptor interacting protein 1. (164 aa)
XRCC4X-ray repair cross complementing 4. (334 aa)
TBL1XTransducin beta like 1 X-linked. (572 aa)
DBNLDrebrin like. (436 aa)
CENPFCentromere protein F. (3114 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (421 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
VGLL2Vestigial like family member 2. (317 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (546 aa)
CCN2Cellular communication network factor 2. (349 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2342 aa)
CTNNB1Catenin beta 1. (781 aa)
DAB2DAB adaptor protein 2. (770 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
NIPBLNipped-B protein. (2804 aa)
VTA1Vesicle trafficking 1. (307 aa)
CIB1Calcium and integrin binding 1. (191 aa)
SASH1SAM and SH3 domain containing 1. (1204 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (694 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (347 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1132 aa)
ENSCSAP00000013601Uncharacterized protein. (637 aa)
LMO7LIM domain 7. (1859 aa)
VPS36Vacuolar protein sorting 36 homolog. (386 aa)
KPNA3Importin subunit alpha; Functions in nuclear protein import. (504 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
ECM1Extracellular matrix protein 1. (540 aa)
TCF4Transcription factor 4. (671 aa)
ATXN1Ataxin 1. (798 aa)
KSR1Kinase suppressor of ras 1. (851 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
CD2APCD2 associated protein. (639 aa)
PICK1Protein interacting with PRKCA 1. (415 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1784 aa)
PAXIP1PAX interacting protein 1. (1121 aa)
ATF4Activating transcription factor 4. (351 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
ENSCSAP00000002584Prohibitin. (259 aa)
PEX12Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family. (359 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
SCLT1Sodium channel and clathrin linker 1. (668 aa)
RABAC1PRA1 family protein. (185 aa)
BCAMBasal cell adhesion molecule (Lutheran blood group). (628 aa)
YAP1Yes associated protein 1. (508 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (736 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
SAE1SUMO1 activating enzyme subunit 1. (310 aa)
NPATNuclear protein, coactivator of histone transcription. (1426 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1531 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (997 aa)
PPP1CCSerine/threonine-protein phosphatase. (293 aa)
ATXN2Ataxin 2. (1151 aa)
IFT46Intraflagellar transport 46. (355 aa)
PDZD3PDZ domain containing 3. (497 aa)
MCAMMelanoma cell adhesion molecule. (646 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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