STRINGSTRING
BMP15 BMP15 TGFA TGFA VEGFD VEGFD GKN1 GKN1 BMP10 BMP10 BMP4 BMP4 GMFB GMFB NRG4 NRG4 EFEMP1 EFEMP1 MANF MANF IL6 IL6 IL3 IL3 CSF2 CSF2 IL5 IL5 IL4 IL4 THPO THPO GDF9 GDF9 JAG1 JAG1 TIMP1 TIMP1 MACC1 MACC1 BMP2 BMP2 IL7 IL7 IL9 IL9 BMP5 BMP5 CDNF CDNF NRG2 NRG2 HBEGF HBEGF OSGIN2 OSGIN2 FGF22 FGF22 RABEP1 RABEP1 GDF6 GDF6 FGF1 FGF1 MSTN MSTN IL12A IL12A PGF PGF VEGFA VEGFA TGFB3 TGFB3 HGF HGF SPEM1 SPEM1 SPEM2 SPEM2 FGF11 FGF11 AMH AMH GFER GFER FGF23 FGF23 FGF6 FGF6 NTF3 NTF3 CXCL12 CXCL12 CCN3 CCN3 FGF16 FGF16 FGF7 FGF7 GDF5 GDF5 FAM71F2 FAM71F2 FAM71F1 FAM71F1 GDF10 GDF10 GDF2 GDF2 NRTN NRTN GDF3 GDF3 IGF2 IGF2 PSPN PSPN FGF18 FGF18 JAG2 JAG2 LIF LIF OSM OSM NRG3 NRG3 ENSCSAP00000005586 ENSCSAP00000005586 FGF3 FGF3 FGF4 FGF4 FGF19 FGF19 FGF12 FGF12 PTN PTN CLCF1 CLCF1 NODAL NODAL TFF1 TFF1 GDF7 GDF7 CD320 CD320 INHA INHA FGF13 FGF13 BMP6 BMP6 OGN OGN DKK1 DKK1 VEGFB VEGFB ENDOU ENDOU PDGFB PDGFB RABEP2 RABEP2 CNTF CNTF FBRS FBRS MDK MDK FGF8 FGF8 LACRT LACRT GDF15 GDF15 GDF11 GDF11 ENSCSAP00000001585 ENSCSAP00000001585 INHBC INHBC INHBE INHBE AMBN AMBN TYMP TYMP ENSCSAP00000001094 ENSCSAP00000001094 PPBP PPBP EPGN EPGN AREG AREG EREG EREG BTC BTC FGF5 FGF5 BMP3 BMP3 IL34 IL34 ENSCSAP00000000323 ENSCSAP00000000323 ENSCSAP00000000320 ENSCSAP00000000320 ENSCSAP00000000314 ENSCSAP00000000314 ENSCSAP00000000309 ENSCSAP00000000309 ENSCSAP00000000300 ENSCSAP00000000300 EGF EGF GMFG GMFG KITLG KITLG IL2 IL2 FGF2 FGF2 NENF NENF BMP7 BMP7 TGFB2 TGFB2 NRG1 NRG1 CSPG5 CSPG5 TDGF1 TDGF1 LEFTY1 LEFTY1 LEFTY2 LEFTY2 BMP1 BMP1 FGF17 FGF17 INHBB INHBB CCN2 CCN2 FGF10 FGF10 FGF20 FGF20 GDNF GDNF HDGFL3 HDGFL3 FGF14 FGF14 PDGFA PDGFA FGF9 FGF9 MIA-RAB4B MIA-RAB4B GRN GRN TGFB1 TGFB1 OSGIN1 OSGIN1 IGF1 IGF1 PDGFC PDGFC PDGFD PDGFD VEGFC VEGFC FGF21 FGF21 CSF3 CSF3 HDGF HDGF CLEC11A CLEC11A IL11 IL11 PROK1 PROK1 CSF1 CSF1 ANGPTL3 ANGPTL3 ARTN ARTN ENSCSAP00000016878 ENSCSAP00000016878 ENSCSAP00000016884 ENSCSAP00000016884 ENSCSAP00000016885 ENSCSAP00000016885 ENSCSAP00000017596 ENSCSAP00000017596 INHBA INHBA THBS4 THBS4 NGF NGF BDNF BDNF VGF VGF NTF4 NTF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP15Bone morphogenetic protein 15. (393 aa)
TGFATransforming growth factor alpha. (158 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
GKN1Gastrokine 1. (199 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GMFBGlia maturation factor beta. (102 aa)
NRG4Neuregulin 4. (117 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (493 aa)
MANFMesencephalic astrocyte derived neurotrophic factor. (179 aa)
IL6Interleukin 6. (212 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (143 aa)
CSF2Colony stimulating factor 2. (144 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
THPOThrombopoietin. (353 aa)
GDF9Growth differentiation factor 9. (455 aa)
JAG1Jagged canonical Notch ligand 1. (1218 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
MACC1MET transcriptional regulator MACC1. (678 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa)
IL9Uncharacterized protein. (145 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
CDNFCerebral dopamine neurotrophic factor. (187 aa)
NRG2Neuregulin 2. (850 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
OSGIN2Oxidative stress induced growth inhibitor family member 2. (546 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
RABEP1Rabaptin, RAB GTPase binding effector protein 1. (862 aa)
GDF6Growth differentiation factor 6. (455 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MSTNMyostatin. (375 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
SPEM1Spermatid maturation 1. (309 aa)
SPEM2SPEM family member 2. (505 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (166 aa)
AMHAnti-Mullerian hormone. (566 aa)
GFERSulfhydryl oxidase. (205 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CCN3Cellular communication network factor 3. (357 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GDF5Growth differentiation factor 5. (499 aa)
FAM71F2Family with sequence similarity 71 member F2. (309 aa)
FAM71F1Family with sequence similarity 71 member F1. (344 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
GDF2Growth differentiation factor 2. (429 aa)
NRTNNeurturin. (197 aa)
GDF3Growth differentiation factor 3. (364 aa)
IGF2Insulin like growth factor 2. (236 aa)
PSPNPersephin. (156 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1245 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
OSMOncostatin M. (252 aa)
NRG3Uncharacterized protein. (376 aa)
ENSCSAP00000005586Uncharacterized protein. (163 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (142 aa)
PTNPleiotrophin. (168 aa)
CLCF1Cardiotrophin like cytokine factor 1. (322 aa)
NODALNodal growth differentiation factor. (347 aa)
TFF1Trefoil factor 1. (84 aa)
GDF7Growth differentiation factor 7. (447 aa)
CD320CD320 molecule. (260 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (242 aa)
BMP6Bone morphogenetic protein 6. (433 aa)
OGNOsteoglycin. (298 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
ENDOUEndonuclease, poly(U) specific. (391 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
RABEP2Rabaptin, RAB GTPase binding effector protein 2. (568 aa)
CNTFCiliary neurotrophic factor. (200 aa)
FBRSFibrosin. (981 aa)
MDKUncharacterized protein. (159 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
LACRTLacritin. (137 aa)
GDF15Growth differentiation factor 15. (308 aa)
GDF11Growth differentiation factor 11. (406 aa)
ENSCSAP00000001585TGF_BETA_2 domain-containing protein. (370 aa)
INHBCInhibin subunit beta C. (352 aa)
INHBEInhibin subunit beta E. (351 aa)
AMBNAmeloblastin. (447 aa)
TYMPThymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (482 aa)
ENSCSAP00000001094C-X-C motif chemokine. (154 aa)
PPBPC-X-C motif chemokine. (126 aa)
EPGNEpithelial mitogen. (154 aa)
AREGAmphiregulin. (252 aa)
EREGEpiregulin. (171 aa)
BTCBetacellulin. (171 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (474 aa)
IL34Interleukin 34. (242 aa)
ENSCSAP00000000323Uncharacterized protein. (178 aa)
ENSCSAP00000000320Uncharacterized protein. (217 aa)
ENSCSAP00000000314Uncharacterized protein. (217 aa)
ENSCSAP00000000309Uncharacterized protein. (217 aa)
ENSCSAP00000000300Uncharacterized protein. (218 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
GMFGGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (142 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
NENFNeudesin neurotrophic factor; Belongs to the cytochrome b5 family. (172 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
NRG1Neuregulin 1. (467 aa)
CSPG5Chondroitin sulfate proteoglycan 5. (562 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (187 aa)
LEFTY1Left-right determination factor. (366 aa)
LEFTY2Left-right determination factor. (366 aa)
BMP1Metalloendopeptidase. (986 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (333 aa)
INHBBInhibin subunit beta B. (320 aa)
CCN2Cellular communication network factor 2. (349 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
HDGFL3HDGF like 3. (203 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
MIA-RAB4BMIA-RAB4B readthrough (NMD candidate). (155 aa)
GRNGranulin precursor. (605 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
OSGIN1Oxidative stress induced growth inhibitor 1. (477 aa)
IGF1Insulin like growth factor 1. (159 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
PDGFDPlatelet derived growth factor D. (332 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
CSF3Colony stimulating factor 3. (207 aa)
HDGFHeparin binding growth factor. (225 aa)
CLEC11AC-type lectin domain containing 11A. (323 aa)
IL11Interleukin 11. (199 aa)
PROK1Prokineticin 1. (105 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (560 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
ARTNArtemin. (220 aa)
ENSCSAP00000016878TGF_BETA_2 domain-containing protein. (354 aa)
ENSCSAP00000016884TGF_BETA_2 domain-containing protein. (292 aa)
ENSCSAP00000016885TGFb_propeptide domain-containing protein. (144 aa)
ENSCSAP00000017596Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
INHBAInhibin subunit beta A. (426 aa)
THBS4Thrombospondin 4. (870 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (241 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (247 aa)
VGFVGF nerve growth factor inducible. (615 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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