STRINGSTRING
HOXD11 HOXD11 KITLG KITLG BMPR1B BMPR1B NUP107 NUP107 SOX9 SOX9 EREG EREG AFP AFP GFRA1 GFRA1 KIT KIT KDR KDR SPINK2 SPINK2 GAS2 GAS2 KIF18A KIF18A FSHB FSHB WT1 WT1 MMP2 MMP2 MMP19 MMP19 SALL1 SALL1 AMHR2 AMHR2 FGF8 FGF8 BIK BIK BOK BOK ROBO2 ROBO2 BRIP1 BRIP1 DHH DHH NUPR1 NUPR1 UBE3A UBE3A DMC1 DMC1 NOS3 NOS3 MAMLD1 MAMLD1 SF1 SF1 CASP2 CASP2 ARID5B ARID5B SIRT1 SIRT1 INHA INHA OSR1 OSR1 RESP18 RESP18 SDC1 SDC1 PTPRN PTPRN SGPL1 SGPL1 DMRT1 DMRT1 SCX SCX YBX3 YBX3 PATZ1 PATZ1 ADAMTS1 ADAMTS1 DMRTA1 DMRTA1 EIF2B4 EIF2B4 LRRC6 LRRC6 SAFB2 SAFB2 ARID4B ARID4B SLIT3 SLIT3 ATN1 ATN1 FANCG FANCG TBC1D20 TBC1D20 NCOA4 NCOA4 RNF38 RNF38 ATRX ATRX TGFBR1 TGFBR1 CYP19A1 CYP19A1 IMMP2L IMMP2L SOX15 SOX15 SRD5A2 SRD5A2 TEX11 TEX11 TMF1 TMF1 PDGFRB PDGFRB AMH AMH ZFPM2 ZFPM2 SOX8 SOX8 AR AR GPR149 GPR149 KDM5A KDM5A TIPARP TIPARP PTX3 PTX3 EIF2B2 EIF2B2 CYP1B1 CYP1B1 MAS1 MAS1 BMP15 BMP15 BCL2L1 BCL2L1 HESX1 HESX1 TNFSF10 TNFSF10 WNT5A WNT5A CTNNA1 CTNNA1 CRKL CRKL GATA1 GATA1 GATA3 GATA3 EIF2B5 EIF2B5 NR5A1 NR5A1 MSH2 MSH2 RDH10 RDH10 ASPM ASPM LHX9 LHX9 LHCGR LHCGR SRC SRC FSHR FSHR AKR1C3 AKR1C3 SIX4 SIX4 HYAL3 HYAL3 ESR1 ESR1 NR0B1 NR0B1 HOXA10 HOXA10 HOXA11 HOXA11 PCYT1B PCYT1B PRDX4 PRDX4 ARID4A ARID4A RHOBTB3 RHOBTB3 REN REN HSD17B4 HSD17B4 WDR48 WDR48 SCAPER SCAPER SPATA2 SPATA2 SFRP1 SFRP1 FER FER LRP2 LRP2 INHBA INHBA TFAP2C TFAP2C SPO11 SPO11 NKX2-1 NKX2-1 TAF4 TAF4 TGFB2 TGFB2 REC8 REC8 BCL2L2 BCL2L2 TNFAIP6 TNFAIP6 COL9A3 COL9A3 ACVR2A ACVR2A NKX3-1 NKX3-1 ENSCSAP00000012589 ENSCSAP00000012589 SLIT2 SLIT2 FST FST INHBB INHBB TCF21 TCF21 BCL2L11 BCL2L11 WDR19 WDR19 GATA4 GATA4 NR2F2 NR2F2 ENSCSAP00000013048 ENSCSAP00000013048 CSMD1 CSMD1 CGA CGA PDGFA PDGFA NUDT1 NUDT1 LFNG LFNG GATA6 GATA6 FNDC3A FNDC3A BRCA2 BRCA2 RXFP2 RXFP2 FGF9 FGF9 SMAD4 SMAD4 BCL2 BCL2 ENSCSAP00000014318 ENSCSAP00000014318 UTF1 UTF1 FZD4 FZD4 SFRP2 SFRP2 ERCC1 ERCC1 STAT5B STAT5B ADAM29 ADAM29 KLHL10 KLHL10 ING2 ING2 ATM ATM TLR3 TLR3 RARA RARA BAX BAX FANCA FANCA CBL CBL TESC TESC NTRK1 NTRK1 ADAM15 ADAM15 TFPT TFPT NUP210L NUP210L RAB13 RAB13 ADAM30 ADAM30 CSDE1 CSDE1 WNT2B WNT2B MSH4 MSH4 LHX8 LHX8 NASP NASP AGO4 AGO4 CSMD2 CSMD2 WNT4 WNT4 ZNF830 ZNF830 CCDC182 CCDC182 TLR5 TLR5 CITED2 CITED2 NHLH2 NHLH2 NRIP1 NRIP1 CEBPB CEBPB FOXL2 FOXL2 BASP1 BASP1 TEX19 TEX19 FOXC1 FOXC1 VGF VGF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HOXD11Homeobox D11. (338 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (536 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (925 aa)
SOX9SRY-box transcription factor 9. (509 aa)
EREGEpiregulin. (171 aa)
AFPAlpha fetoprotein. (609 aa)
GFRA1GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (467 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
SPINK2Kazal-like domain-containing protein. (81 aa)
GAS2Uncharacterized protein. (167 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (897 aa)
FSHBFollicle stimulating hormone subunit beta. (129 aa)
WT1WT1 transcription factor. (320 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
MMP19Matrix metallopeptidase 19. (429 aa)
SALL1Spalt like transcription factor 1. (1321 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (573 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
BIKBCL2 interacting killer. (159 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
ROBO2Roundabout guidance receptor 2. (1235 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1248 aa)
DHHDesert hedgehog signaling molecule. (298 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (872 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
NOS3Nitric oxide synthase 3. (867 aa)
MAMLD1Mastermind like domain containing 1. (810 aa)
SF1Splicing factor 1. (548 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (453 aa)
ARID5BAT-rich interaction domain 5B. (1127 aa)
SIRT1Sirtuin 1. (743 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
RESP18Regulated endocrine specific protein 18. (177 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (979 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (278 aa)
SCXScleraxis bHLH transcription factor. (201 aa)
YBX3Y-box binding protein 3. (373 aa)
PATZ1POZ/BTB and AT hook containing zinc finger 1. (537 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
DMRTA1DMRT like family A1. (366 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (523 aa)
LRRC6Leucine rich repeat containing 6. (466 aa)
SAFB2Scaffold attachment factor B2. (953 aa)
ARID4BAT-rich interaction domain 4B. (1314 aa)
SLIT3Slit guidance ligand 3. (1320 aa)
ATN1Atrophin 1. (1183 aa)
FANCGFA complementation group G. (622 aa)
TBC1D20TBC1 domain family member 20. (403 aa)
NCOA4Nuclear receptor coactivator 4. (615 aa)
RNF38Ring finger protein 38. (432 aa)
ATRXATRX chromatin remodeler. (2459 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
IMMP2LUncharacterized protein. (80 aa)
SOX15SRY-box transcription factor 15. (233 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
TEX11Testis expressed 11. (633 aa)
TMF1TATA element modulatory factor 1. (1092 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
AMHAnti-Mullerian hormone. (566 aa)
ZFPM2Zinc finger protein, FOG family member 2. (940 aa)
SOX8SRY-box transcription factor 8. (446 aa)
ARAndrogen receptor. (900 aa)
GPR149G protein-coupled receptor 149. (731 aa)
KDM5ALysine demethylase 5A. (1636 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (657 aa)
PTX3Pentraxin 3. (381 aa)
EIF2B2Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (542 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
BCL2L1BCL2 like 1. (233 aa)
HESX1HESX homeobox 1. (112 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (281 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CTNNA1Catenin alpha 1. (906 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
GATA1GATA binding protein 1. (414 aa)
GATA3GATA binding protein 3. (443 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (720 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (933 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
ASPMAbnormal spindle microtubule assembly. (2794 aa)
LHX9LIM homeobox 9. (271 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (701 aa)
SRCTyrosine-protein kinase. (633 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (669 aa)
AKR1C3Aldo-keto reductase family 1 member C3. (326 aa)
SIX4SIX homeobox 4. (780 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
ESR1Estrogen receptor 1. (487 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (470 aa)
HOXA10Homeobox domain-containing protein. (94 aa)
HOXA11Homeobox A11. (310 aa)
PCYT1BPhosphate cytidylyltransferase 1, choline, beta. (369 aa)
PRDX4Peroxiredoxin 4. (271 aa)
ARID4AAT-rich interaction domain 4A. (1006 aa)
RHOBTB3Rho related BTB domain containing 3. (611 aa)
RENRenin; Belongs to the peptidase A1 family. (406 aa)
HSD17B4Hydroxysteroid 17-beta dehydrogenase 4. (735 aa)
WDR48WD repeat domain 48. (677 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1018 aa)
SPATA2Spermatogenesis associated 2. (520 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
LRP2LDL receptor related protein 2. (3861 aa)
INHBAInhibin subunit beta A. (426 aa)
TFAP2CTranscription factor AP-2 gamma. (251 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (397 aa)
NKX2-1NK2 homeobox 1. (371 aa)
TAF4TATA-box binding protein associated factor 4. (842 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
REC8REC8 meiotic recombination protein. (517 aa)
BCL2L2BCL2 like 2. (193 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
COL9A3Uncharacterized protein. (684 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
NKX3-1NK3 homeobox 1. (232 aa)
ENSCSAP00000012589LRRNT domain-containing protein. (132 aa)
SLIT2Slit guidance ligand 2. (1332 aa)
FSTFollistatin. (344 aa)
INHBBInhibin subunit beta B. (320 aa)
TCF21Transcription factor 21. (179 aa)
BCL2L11BCL2 like 11. (109 aa)
WDR19WD repeat domain 19. (1342 aa)
GATA4GATA binding protein 4. (442 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
ENSCSAP00000013048Uncharacterized protein. (152 aa)
CSMD1Uncharacterized protein. (1618 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
NUDT1Nudix hydrolase 1; Belongs to the Nudix hydrolase family. (156 aa)
LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (236 aa)
GATA6GATA binding protein 6. (595 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
BRCA2BRCA2 DNA repair associated. (3420 aa)
RXFP2Relaxin family peptide receptor 2. (754 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ENSCSAP00000014318Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (283 aa)
UTF1Undifferentiated embryonic cell transcription factor 1. (341 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
ADAM29ADAM metallopeptidase domain 29. (820 aa)
KLHL10Kelch like family member 10. (608 aa)
ING2Inhibitor of growth protein. (280 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
RARARetinoic acid receptor alpha. (462 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
FANCAFA complementation group A. (1455 aa)
CBLCbl proto-oncogene. (907 aa)
TESCTescalcin. (201 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
ADAM15ADAM metallopeptidase domain 15. (754 aa)
TFPTTCF3 fusion partner. (253 aa)
NUP210LNucleoporin 210 like. (1792 aa)
RAB13Uncharacterized protein. (245 aa)
ADAM30ADAM metallopeptidase domain 30. (791 aa)
CSDE1Cold shock domain containing E1. (844 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (347 aa)
MSH4MutS homolog 4. (935 aa)
LHX8LIM homeobox 8. (352 aa)
NASPNuclear autoantigenic sperm protein. (463 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
CSMD2CUB and Sushi multiple domains 2. (3463 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ZNF830Zinc finger protein 830. (372 aa)
CCDC182Coiled-coil domain containing 182. (153 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
NHLH2Nescient helix-loop-helix 2. (135 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
FOXL2Forkhead box L2. (376 aa)
BASP1Brain abundant membrane attached signal protein 1. (227 aa)
TEX19Testis expressed 19. (164 aa)
FOXC1Forkhead box C1. (552 aa)
VGFVGF nerve growth factor inducible. (615 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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