STRINGSTRING
FRS2 FRS2 DDIT3 DDIT3 TDRD1 TDRD1 PAX6 PAX6 WT1 WT1 LDB1 LDB1 ARL13B ARL13B TBX6 TBX6 WNT1 WNT1 PTCH1 PTCH1 SHH SHH ZIC3 ZIC3 NODAL NODAL ETS2 ETS2 PLD6 PLD6 WNT6 WNT6 CHRDL1 CHRDL1 CER1 CER1 RIPPLY1 RIPPLY1 WNT7A WNT7A BMPR1A BMPR1A GDF3 GDF3 SMO SMO SRF SRF C2orf66 C2orf66 PGAP1 PGAP1 TTC8 TTC8 MDFI MDFI FOXA2 FOXA2 CDX1 CDX1 DLL1 DLL1 MNS1 MNS1 TDRD5 TDRD5 TBXT TBXT TDRD6 TDRD6 TASOR TASOR AXIN1 AXIN1 RNF2 RNF2 WNT5A WNT5A SMAD6 SMAD6 WNT8A WNT8A SIX3 SIX3 SIX2 SIX2 TIFAB TIFAB KDM6A KDM6A CDX4 CDX4 BCOR BCOR OTX2 OTX2 BMP4 BMP4 SFRP1 SFRP1 VAX2 VAX2 AURKA AURKA NOTCH1 NOTCH1 COBL COBL TDGF1 TDGF1 STC1 STC1 HEY2 HEY2 EPB41L5 EPB41L5 FGF10 FGF10 AHI1 AHI1 PCSK6 PCSK6 CTNNB1 CTNNB1 MESP2 MESP2 MESP1 MESP1 IRX4 IRX4 RIPPLY2 RIPPLY2 SETDB2 SETDB2 CDX2 CDX2 SMAD2 SMAD2 SMAD4 SMAD4 FAM76B FAM76B MTHFSD MTHFSD TBX3 TBX3 TMED2 TMED2 TDRD10 TDRD10 TDRKH TDRKH NOTCH2 NOTCH2 WDR77 WDR77 NRARP NRARP BASP1 BASP1 FZD5 FZD5 CITED2 CITED2 TDRD15 TDRD15 NEUROG1 NEUROG1 SKI SKI FAM76A FAM76A WLS WLS HSPB11 HSPB11 STIL STIL WNT3 WNT3 PITX2 PITX2 CXXC4 CXXC4 C2CD3 C2CD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (192 aa)
TDRD1Tudor domain containing 1. (1190 aa)
PAX6Paired box 6. (436 aa)
WT1WT1 transcription factor. (320 aa)
LDB1LIM domain binding 1. (411 aa)
ARL13BADP ribosylation factor like GTPase 13B. (428 aa)
TBX6T-box transcription factor 6. (436 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PTCH1Patched 1. (1452 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
ZIC3Zic family member 3. (466 aa)
NODALNodal growth differentiation factor. (347 aa)
ETS2ETS proto-oncogene 2, transcription factor. (391 aa)
PLD6Phospholipase D family member 6. (249 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CHRDL1Chordin like 1. (458 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
RIPPLY1Uncharacterized protein. (80 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GDF3Growth differentiation factor 3. (364 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
SRFSerum response factor. (508 aa)
C2orf66Chromosome 2 open reading frame 66. (113 aa)
PGAP1GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi. (922 aa)
TTC8Tetratricopeptide repeat domain 8. (515 aa)
MDFIMyoD family inhibitor. (246 aa)
FOXA2Forkhead box A2. (463 aa)
CDX1Caudal type homeobox 1. (265 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
MNS1Meiosis specific nuclear structural 1. (494 aa)
TDRD5Tudor domain containing 5. (978 aa)
TBXTT-box transcription factor T. (436 aa)
TDRD6Tudor domain containing 6. (2097 aa)
TASORTranscription activation suppressor. (1514 aa)
AXIN1Axin 1. (867 aa)
RNF2Ring finger protein 2. (336 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SIX3SIX homeobox 3. (331 aa)
SIX2SIX homeobox 2. (290 aa)
TIFABTIFA inhibitor. (161 aa)
KDM6ALysine demethylase 6A. (1453 aa)
CDX4Caudal type homeobox 4. (284 aa)
BCORBCL6 corepressor. (1721 aa)
OTX2Orthodenticle homeobox 2. (223 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
VAX2Ventral anterior homeobox 2. (290 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (403 aa)
NOTCH1Notch receptor 1. (2555 aa)
COBLCordon-bleu WH2 repeat protein. (1302 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (187 aa)
STC1Stanniocalcin 1. (247 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (699 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
AHI1Abelson helper integration site 1. (1202 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (839 aa)
CTNNB1Catenin beta 1. (781 aa)
MESP2Uncharacterized protein. (205 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
IRX4Iroquois homeobox 4. (515 aa)
RIPPLY2Ripply transcriptional repressor 2. (128 aa)
SETDB2SET domain bifurcated histone lysine methyltransferase 2. (707 aa)
CDX2Caudal type homeobox 2. (313 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FAM76BFamily with sequence similarity 76 member B. (323 aa)
MTHFSDMethenyltetrahydrofolate synthetase domain containing. (395 aa)
TBX3T-box transcription factor 3. (723 aa)
TMED2Transmembrane p24 trafficking protein 2. (208 aa)
TDRD10Tudor domain containing 10. (366 aa)
TDRKHTudor and KH domain containing. (561 aa)
NOTCH2Notch receptor 2. (2471 aa)
WDR77WD repeat domain 77. (342 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
BASP1Brain abundant membrane attached signal protein 1. (227 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (273 aa)
TDRD15Tudor domain containing 15. (1935 aa)
NEUROG1Neurogenin 1. (237 aa)
SKISKI proto-oncogene. (728 aa)
FAM76AFamily with sequence similarity 76 member A. (307 aa)
WLSWnt ligand secretion mediator. (564 aa)
HSPB11Heat shock protein family B (small) member 11. (151 aa)
STILSTIL centriolar assembly protein. (1287 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
PITX2Homeobox protein. (325 aa)
CXXC4CXXC finger protein 4. (198 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2361 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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