STRINGSTRING
PHF14 PHF14 CHRD CHRD BMP4 BMP4 CTNNB1 CTNNB1 IRS2 IRS2 LMNA LMNA PDGFA PDGFA FGF9 FGF9 CTNNBIP1 CTNNBIP1 WNT2 WNT2 BMPR1A BMPR1A TGFBR2 TGFBR2 NFIB NFIB LRP5 LRP5 IHH IHH SHH SHH KDR KDR ZEB1 ZEB1 TBX1 TBX1 SHOX2 SHOX2 STAT1 STAT1 WNT5A WNT5A FOXF1 FOXF1 WNT11 WNT11 SOX9 SOX9 FGFR2 FGFR2 PRRX1 PRRX1 SMO SMO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PHF14PHD finger protein 14. (956 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (956 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CTNNB1Catenin beta 1. (781 aa)
IRS2Insulin receptor substrate 2. (906 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (663 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
LRP5LDL receptor related protein 5. (1451 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1124 aa)
TBX1T-box transcription factor 1. (490 aa)
SHOX2Short stature homeobox 2. (331 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FOXF1Forkhead box F1. (354 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SOX9SRY-box transcription factor 9. (509 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
PRRX1Paired related homeobox 1. (217 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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