STRINGSTRING
NOS3 NOS3 FBXW9 FBXW9 HDAC7 HDAC7 CALR CALR PDGFB PDGFB BCAS3 BCAS3 ACVRL1 ACVRL1 ENSCSAP00000002108 ENSCSAP00000002108 SP1 SP1 ATP5F1B ATP5F1B KDR KDR CXCL13 CXCL13 ANXA3 ANXA3 PRKCA PRKCA APOH APOH EGF EGF MAP3K3 MAP3K3 ITGB3 ITGB3 DCN DCN BCAR1 BCAR1 FGF2 FGF2 CIB1 CIB1 ANGPT2 ANGPT2 NR2F2 NR2F2 ENSCSAP00000012988 ENSCSAP00000012988 SLIT2 SLIT2 ENSCSAP00000012589 ENSCSAP00000012589 ATOH8 ATOH8 STC1 STC1 TDGF1 TDGF1 PLK2 PLK2 NUS1 NUS1 PTK2B PTK2B NOTCH1 NOTCH1 PRKD1 PRKD1 ADGRA2 ADGRA2 PROX1 PROX1 FGFR1 FGFR1 NR2E1 NR2E1 RHOA RHOA BMP10 BMP10 BMPER BMPER DNAJA4 DNAJA4 BMP4 BMP4 ABL1 ABL1 CD40 CD40 MEF2C MEF2C ATP2B4 ATP2B4 NFE2L2 NFE2L2 HRG HRG HIF1A HIF1A RHOJ RHOJ PLCG1 PLCG1 SERPINF1 SERPINF1 ENSCSAP00000009708 ENSCSAP00000009708 ENSCSAP00000009705 ENSCSAP00000009705 HDAC9 HDAC9 GATA3 GATA3 MEOX2 MEOX2 MAP2K5 MAP2K5 DAB2IP DAB2IP PTGS2 PTGS2 BSG BSG SYNJ2BP SYNJ2BP WNT5A WNT5A KRIT1 KRIT1 PDCD10 PDCD10 GLUL GLUL FGF1 FGF1 ALOX12 ALOX12 VEGFA VEGFA SMOC2 SMOC2 ADAMTS9 ADAMTS9 VASH1 VASH1 ANGPT1 ANGPT1 JCAD JCAD FOXP1 FOXP1 RIN2 RIN2 KLF4 KLF4 PIK3CG PIK3CG NRP1 NRP1 LGMN LGMN PIK3CB PIK3CB TBXA2R TBXA2R MET MET SPARC SPARC AGT AGT BMPR2 BMPR2 ANGPT4 ANGPT4 SRPX2 SRPX2 NRP2 NRP2 GDF2 GDF2 TEK TEK MMRN2 MMRN2 AKT1 AKT1 FGF18 FGF18 PTK2 PTK2 WNT7A WNT7A AKT3 AKT3 FGF4 FGF4 ADGRB1 ADGRB1 TSTA3 TSTA3 PTN PTN AAMP AAMP PATZ1 PATZ1 GATA2 GATA2 EMP2 EMP2 HMOX1 HMOX1 ANXA1 ANXA1 FLT4 FLT4 GPLD1 GPLD1 MAP2K3 MAP2K3 DLL4 DLL4 SIRT1 SIRT1 CARD10 CARD10 ROCK2 ROCK2 THBS1 THBS1 SPRED1 SPRED1 ADAM17 ADAM17 ITGB1BP1 ITGB1BP1 SP100 SP100 MECP2 MECP2 NF1 NF1 FGFBP1 FGFBP1 FUT1 FUT1 ENSCSAP00000019137 ENSCSAP00000019137 AGTR2 AGTR2 FOXC2 FOXC2 RHOB RHOB PIK3CD PIK3CD EPHA2 EPHA2 ZC3H12A ZC3H12A SVBP SVBP PLPP3 PLPP3 GADD45A GADD45A ZNF580 ZNF580 SCARB1 SCARB1 EFNA1 EFNA1 SEMA4A SEMA4A EMC10 EMC10 P2RX4 P2RX4 ETS1 ETS1 RRAS RRAS JUP JUP PRKD2 PRKD2 VEGFC VEGFC STAT5A STAT5A APOE APOE FBXW7 FBXW7 CEACAM1 CEACAM1 TGFB1 TGFB1 GRN GRN PDPK1 PDPK1 CCBE1 CCBE1 HSPB1 HSPB1 ATP5F1A ATP5F1A STARD13 STARD13 RGCC RGCC PTPRM PTPRM SEMA5A SEMA5A ENSCSAP00000013290 ENSCSAP00000013290 SASH1 SASH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOS3Nitric oxide synthase 3. (867 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (954 aa)
CALRCalreticulin. (417 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
BCAS3BCAS3 domain-containing protein. (665 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ENSCSAP00000002108WD_REPEATS_REGION domain-containing protein. (434 aa)
SP1Sp1 transcription factor. (786 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (529 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
CXCL13C-X-C motif chemokine. (109 aa)
ANXA3Annexin. (323 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (620 aa)
APOHApolipoprotein H. (266 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (870 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (288 aa)
CIB1Calcium and integrin binding 1. (191 aa)
ANGPT2Angiopoietin 2. (495 aa)
NR2F2Nuclear receptor subfamily 2 group F member 2. (414 aa)
ENSCSAP00000012988BCAS3 domain-containing protein. (913 aa)
SLIT2Slit guidance ligand 2. (1332 aa)
ENSCSAP00000012589LRRNT domain-containing protein. (132 aa)
ATOH8Atonal bHLH transcription factor 8. (330 aa)
STC1Stanniocalcin 1. (247 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (187 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
NOTCH1Notch receptor 1. (2555 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (824 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1338 aa)
PROX1Prospero homeobox 1. (737 aa)
FGFR1Fibroblast growth factor receptor. (830 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
RHOARas homolog family member A. (193 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
BMPERBMP binding endothelial regulator. (685 aa)
DNAJA4DnaJ heat shock protein family (Hsp40) member A4. (426 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ABL1Tyrosine-protein kinase. (1130 aa)
CD40CD40 molecule. (278 aa)
MEF2CMyocyte enhancer factor 2C. (446 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1170 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
HRGHistidine rich glycoprotein. (521 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
RHOJRas homolog family member J. (214 aa)
PLCG1Phosphoinositide phospholipase C. (974 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (420 aa)
ENSCSAP00000009708Hist_deacetyl domain-containing protein. (156 aa)
ENSCSAP00000009705Hist_deacetyl domain-containing protein. (114 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (780 aa)
GATA3GATA binding protein 3. (443 aa)
MEOX2Mesenchyme homeobox 2. (303 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
DAB2IPDAB2 interacting protein. (1036 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (572 aa)
BSGBasigin (Ok blood group). (385 aa)
SYNJ2BPSynaptojanin 2 binding protein. (125 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
KRIT1Uncharacterized protein. (736 aa)
PDCD10Programmed cell death 10. (212 aa)
GLULGlutamine synthetase. (373 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (663 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
SMOC2SPARC related modular calcium binding 2. (446 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1764 aa)
VASH1Vasohibin 1. (365 aa)
ANGPT1Angiopoietin 1. (407 aa)
JCADJunctional cadherin 5 associated. (1357 aa)
FOXP1Fork-head domain-containing protein. (677 aa)
RIN2Ras and Rab interactor 2. (895 aa)
KLF4Kruppel like factor 4. (479 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (918 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
LGMNLegumain. (433 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TBXA2RThromboxane A2 receptor. (343 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1381 aa)
SPARCSecreted protein acidic and cysteine rich. (303 aa)
AGTAngiotensinogen; Belongs to the serpin family. (485 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ANGPT4Angiopoietin 4. (503 aa)
SRPX2Sushi repeat containing protein X-linked 2. (427 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (901 aa)
GDF2Growth differentiation factor 2. (429 aa)
TEKTEK receptor tyrosine kinase. (1123 aa)
MMRN2Multimerin 2. (951 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1038 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
ADGRB1Adhesion G protein-coupled receptor B1; Belongs to the G-protein coupled receptor 2 family. (1587 aa)
TSTA3Tissue specific transplantation antigen P35B. (321 aa)
PTNPleiotrophin. (168 aa)
AAMPWD_REPEATS_REGION domain-containing protein. (435 aa)
PATZ1POZ/BTB and AT hook containing zinc finger 1. (537 aa)
GATA2GATA binding protein 2. (397 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
HMOX1Heme oxygenase 1. (288 aa)
ANXA1Annexin. (346 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1361 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (638 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
SIRT1Sirtuin 1. (743 aa)
CARD10Caspase recruitment domain family member 10. (1051 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
THBS1Thrombospondin 1. (1170 aa)
SPRED1Sprouty related EVH1 domain containing 1. (444 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
SP100SP100 nuclear antigen. (851 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (479 aa)
NF1Neurofibromin 1. (2849 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (366 aa)
ENSCSAP00000019137L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (357 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
FOXC2Forkhead box C2. (501 aa)
RHOBRas homolog family member B. (196 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
EPHA2EPH receptor A2. (1033 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
SVBPSmall vasohibin binding protein. (66 aa)
PLPP3acidPPc domain-containing protein. (353 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
ZNF580Zinc finger protein 580. (172 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (470 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (810 aa)
EMC10ER membrane protein complex subunit 10. (262 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (358 aa)
ETS1ETS proto-oncogene 1, transcription factor. (441 aa)
RRASRAS related. (218 aa)
JUPJunction plakoglobin. (745 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
STAT5ASignal transducer and activator of transcription. (798 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
CEACAM1Uncharacterized protein. (525 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GRNGranulin precursor. (605 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (580 aa)
CCBE1Collagen and calcium binding EGF domains 1. (336 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (143 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
STARD13StAR related lipid transfer domain containing 13. (1076 aa)
RGCCRegulator of cell cycle. (137 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1445 aa)
SEMA5ASemaphorin 5A. (1074 aa)
ENSCSAP00000013290ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (507 aa)
SASH1SAM and SH3 domain containing 1. (1204 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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