STRINGSTRING
BMP4 BMP4 TBX20 TBX20 FERMT2 FERMT2 SNAI1 SNAI1 BMP7 BMP7 OLFM1 OLFM1 ZNF703 ZNF703 HDAC2 HDAC2 TGFB2 TGFB2 NOTCH1 NOTCH1 ACVR1 ACVR1 LOXL2 LOXL2 ISL1 ISL1 IL1B IL1B CTNNB1 CTNNB1 ALX1 ALX1 LEF1 LEF1 AXIN2 AXIN2 ENSCSAP00000001444 ENSCSAP00000001444 COL1A1 COL1A1 MDK MDK EZH2 EZH2 GCNT2 GCNT2 EMP2 EMP2 ENSCSAP00000005586 ENSCSAP00000005586 TIAM1 TIAM1 TGFBR2 TGFBR2 LRG1 LRG1 GLIPR2 GLIPR2 TGFBR1 TGFBR1 WWTR1 WWTR1 BAMBI BAMBI TGFB3 TGFB3 SMAD3 SMAD3 CRB2 CRB2 BMP2 BMP2 JAG1 JAG1 ENG ENG IL6 IL6 ENSCSAP00000010642 ENSCSAP00000010642 DAB2 DAB2 RGCC RGCC SMAD2 SMAD2 SMAD4 SMAD4 TGFB1 TGFB1 BCL9L BCL9L PDPN PDPN MTOR MTOR SDCBP SDCBP FOXC1 FOXC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP4Bone morphogenetic protein 4. (408 aa)
TBX20T-box transcription factor 20. (447 aa)
FERMT2Fermitin family member 2. (507 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
OLFM1Olfactomedin 1. (328 aa)
ZNF703Zinc finger protein 703. (590 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
NOTCH1Notch receptor 1. (2555 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
LOXL2Lysyl oxidase like 2. (774 aa)
ISL1ISL LIM homeobox 1. (349 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
CTNNB1Catenin beta 1. (781 aa)
ALX1ALX homeobox 1. (327 aa)
LEF1Lymphoid enhancer binding factor 1. (331 aa)
AXIN2Axin 2. (843 aa)
ENSCSAP00000001444HMG box domain-containing protein. (377 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
MDKUncharacterized protein. (159 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
ENSCSAP00000005586Uncharacterized protein. (163 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1466 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (154 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CRB2Crumbs cell polarity complex component 2. (1287 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
JAG1Jagged canonical Notch ligand 1. (1218 aa)
ENGEndoglin. (658 aa)
IL6Interleukin 6. (212 aa)
ENSCSAP00000010642Uncharacterized protein. (241 aa)
DAB2DAB adaptor protein 2. (770 aa)
RGCCRegulator of cell cycle. (137 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
BCL9LBCL9 like. (1500 aa)
PDPNPodoplanin. (162 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SDCBPUncharacterized protein. (293 aa)
FOXC1Forkhead box C1. (552 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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