STRINGSTRING
ENSCSAP00000017596 ENSCSAP00000017596 ARHGAP4 ARHGAP4 SOX10 SOX10 PLXNA3 PLXNA3 CDK5 CDK5 NF1 NF1 NPPC NPPC FBXW9 FBXW9 TMEM98 TMEM98 TBX6 TBX6 DIP2B DIP2B SLIT1 SLIT1 LRP4 LRP4 F2 F2 TSPO TSPO SEMA4G SEMA4G PITX3 PITX3 FBLN1 FBLN1 PAX6 PAX6 REST REST MT3 MT3 RUFY3 RUFY3 VAX1 VAX1 ABCC8 ABCC8 MAG MAG NKX6-1 NKX6-1 NKX6-2 NKX6-2 SPP1 SPP1 PPP3CA PPP3CA SIRT2 SIRT2 AP1AR AP1AR DLL3 DLL3 WNT3 WNT3 DICER1 DICER1 RYK RYK CAV3 CAV3 ENSCSAP00000007050 ENSCSAP00000007050 SHB SHB DAAM2 DAAM2 IFRD1 IFRD1 TREM2 TREM2 EFNB3 EFNB3 TP53 TP53 NRP1 NRP1 KIFAP3 KIFAP3 PRTG PRTG TNR TNR SEMA3E SEMA3E SEMA3A SEMA3A SEMA3D SEMA3D SPRY4 SPRY4 FRZB FRZB ID1 ID1 PSEN1 PSEN1 WNT5A WNT5A DYNLT1 DYNLT1 CTNNA1 CTNNA1 BRINP1 BRINP1 SEMA3G SEMA3G LHX2 LHX2 TRPV1 TRPV1 FSTL4 FSTL4 RTN4 RTN4 GPR37L1 GPR37L1 ENSCSAP00000010227 ENSCSAP00000010227 DNAJB11 DNAJB11 TTPAL TTPAL SEMA7A SEMA7A IFRD2 IFRD2 TTPA TTPA RFLNB RFLNB SEMA3B SEMA3B SEMA3F SEMA3F BCL11A BCL11A SEMA6A SEMA6A GORASP1 GORASP1 DLX2 DLX2 DLX1 DLX1 HOOK3 HOOK3 NR2E1 NR2E1 EFNA5 EFNA5 BMP7 BMP7 PROX1 PROX1 FBN1 FBN1 SEMA6B SEMA6B NTN1 NTN1 MAP2 MAP2 PTPRS PTPRS CDKN2B CDKN2B BMPR1A BMPR1A NF2 NF2 B2M B2M SYNGAP1 SYNGAP1 WNT7A WNT7A PTN PTN CTDSP1 CTDSP1 MELTF MELTF TRPC5 TRPC5 KANK1 KANK1 YWHAH YWHAH NODAL NODAL WEE2 WEE2 ULK2 ULK2 KIAA0319 KIAA0319 ID4 ID4 PTHLH PTHLH SEMA5B SEMA5B FGF13 FGF13 MCF2 MCF2 SEMA4D SEMA4D ITGB1BP1 ITGB1BP1 GSK3B GSK3B PTEN PTEN LDLR LDLR LINGO1 LINGO1 RTN4R RTN4R ASCL2 ASCL2 S1PR3 S1PR3 SOX11 SOX11 ATOH1 ATOH1 NOG NOG SKI SKI HES5 HES5 DRAXIN DRAXIN RCC2 RCC2 EPHB2 EPHB2 LIN28A LIN28A TACSTD2 TACSTD2 SEMA6C SEMA6C ENSCSAP00000016198 ENSCSAP00000016198 ULK1 ULK1 NPR2 NPR2 TRIM46 TRIM46 RFLNA RFLNA SEMA4A SEMA4A RNF10 RNF10 SORL1 SORL1 THY1 THY1 NR1D1 NR1D1 CORO1C CORO1C APPL2 APPL2 RAPGEF2 RAPGEF2 IGF1 IGF1 FBXW7 FBXW7 GSK3A GSK3A TGFB1 TGFB1 DCC DCC MBD1 MBD1 CERS2 CERS2 RNF6 RNF6 SYT4 SYT4 SPART SPART RB1 RB1 GDI1 GDI1 EDNRB EDNRB SEMA5A SEMA5A SEMA4C SEMA4C SEMA4B SEMA4B CTNNB1 CTNNB1 PCM1 PCM1 DMTN DMTN TRIM11 TRIM11 WNT3A WNT3A LTF LTF DUSP10 DUSP10 NOTCH1 NOTCH1 NFATC4 NFATC4 SEMA4F SEMA4F TLX2 TLX2 ENSCSAP00000011735 ENSCSAP00000011735 PAEP PAEP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCSAP00000017596Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
ARHGAP4Rho GTPase activating protein 4. (946 aa)
SOX10SRY-box transcription factor 10. (236 aa)
PLXNA3Plexin A3. (1871 aa)
CDK5Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (224 aa)
NF1Neurofibromin 1. (2849 aa)
NPPCNatriuretic peptide C. (126 aa)
FBXW9F-box and WD repeat domain containing 9. (458 aa)
TMEM98Transmembrane protein 98. (226 aa)
TBX6T-box transcription factor 6. (436 aa)
DIP2BDisco interacting protein 2 homolog B. (1576 aa)
SLIT1Slit guidance ligand 1. (1396 aa)
LRP4LDL receptor related protein 4. (1669 aa)
F2Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (596 aa)
TSPOTranslocator protein. (193 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (810 aa)
PITX3Homeobox protein. (302 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (703 aa)
PAX6Paired box 6. (436 aa)
RESTRE1 silencing transcription factor. (1096 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (68 aa)
RUFY3RUN and FYVE domain containing 3. (487 aa)
VAX1Ventral anterior homeobox 1. (333 aa)
ABCC8ATP binding cassette subfamily C member 8. (1581 aa)
MAGMyelin associated glycoprotein. (626 aa)
NKX6-1NK6 homeobox 1. (366 aa)
NKX6-2NK6 homeobox 2. (277 aa)
SPP1Secreted phosphoprotein 1. (314 aa)
PPP3CASerine/threonine-protein phosphatase. (471 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
AP1ARAdaptor related protein complex 1 associated regulatory protein. (282 aa)
DLL3Delta like canonical Notch ligand 3. (614 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1920 aa)
RYKReceptor like tyrosine kinase. (609 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ENSCSAP00000007050Uncharacterized protein. (2022 aa)
SHBSH2 domain containing adaptor protein B. (509 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1068 aa)
IFRD1Interferon related developmental regulator 1. (456 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (260 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
KIFAP3Kinesin associated protein 3. (794 aa)
PRTGProtogenin. (1204 aa)
TNRTenascin R. (1034 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (715 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (746 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
SPRY4Sprouty RTK signaling antagonist 4. (322 aa)
FRZBFrizzled related protein. (325 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
PSEN1Presenilin 1. (467 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
DYNLT1Dynein light chain Tctex-type 1. (122 aa)
CTNNA1Catenin alpha 1. (906 aa)
BRINP1BMP/retinoic acid inducible neural specific 1. (761 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (782 aa)
LHX2LIM homeobox 2. (406 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (828 aa)
FSTL4Follistatin like 4. (745 aa)
RTN4Reticulon. (199 aa)
GPR37L1G protein-coupled receptor 37 like 1. (481 aa)
ENSCSAP00000010227Uncharacterized protein. (225 aa)
DNAJB11J domain-containing protein. (358 aa)
TTPALAlpha tocopherol transfer protein like. (342 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (501 aa)
IFRD2Interferon related developmental regulator 2. (510 aa)
TTPAAlpha tocopherol transfer protein. (239 aa)
RFLNBRefilin B. (216 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (748 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (754 aa)
BCL11AC2H2-type domain-containing protein. (243 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1043 aa)
GORASP1Golgi reassembly stacking protein 1. (447 aa)
DLX2Distal-less homeobox 2. (329 aa)
DLX1Distal-less homeobox 1. (255 aa)
HOOK3Hook microtubule tethering protein 3. (698 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (197 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PROX1Prospero homeobox 1. (737 aa)
FBN1Fibrillin 1. (2666 aa)
SEMA6BSema domain-containing protein; Belongs to the semaphorin family. (374 aa)
NTN1Netrin 1. (604 aa)
MAP2Microtubule-associated protein. (1997 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1941 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (137 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NF2Neurofibromin 2. (590 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1259 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PTNPleiotrophin. (168 aa)
CTDSP1CTD small phosphatase 1. (260 aa)
MELTFMelanotransferrin; Belongs to the transferrin family. (733 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
KANK1KN motif and ankyrin repeat domains 1. (1352 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
NODALNodal growth differentiation factor. (347 aa)
WEE2Wee1-like protein kinase. (567 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1036 aa)
KIAA0319KIAA0319. (912 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
PTHLHParathyroid hormone like hormone. (177 aa)
SEMA5BSemaphorin 5B. (1152 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (242 aa)
MCF2MCF.2 cell line derived transforming sequence. (1070 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LDLRLow density lipoprotein receptor. (767 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
RTN4RReticulon 4 receptor. (470 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
S1PR3Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa)
SOX11Transcription factor SOX. (441 aa)
ATOH1Atonal bHLH transcription factor 1. (354 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SKISKI proto-oncogene. (728 aa)
HES5Hes family bHLH transcription factor 5. (166 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
RCC2Regulator of chromosome condensation 2. (552 aa)
EPHB2EPH receptor B2. (975 aa)
LIN28ALin-28 homolog A. (210 aa)
TACSTD2Tumor associated calcium signal transducer 2. (339 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (931 aa)
ENSCSAP00000016198Uncharacterized protein. (710 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1070 aa)
NPR2Guanylate cyclase. (1047 aa)
TRIM46Tripartite motif containing 46. (759 aa)
RFLNARefilin A. (216 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (810 aa)
RNF10Ring finger protein 10. (760 aa)
SORL1Sortilin related receptor 1. (2214 aa)
THY1Thy-1 cell surface antigen. (161 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (483 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (664 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1685 aa)
IGF1Insulin like growth factor 1. (159 aa)
FBXW7F-box and WD repeat domain containing 7. (707 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (483 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
DCCDCC netrin 1 receptor. (1420 aa)
MBD1Methyl-CpG binding domain protein 1. (605 aa)
CERS2Ceramide synthase 2. (380 aa)
RNF6Ring finger protein 6. (685 aa)
SYT4Synaptotagmin 4. (425 aa)
SPARTSpartin. (666 aa)
RB1RB transcriptional corepressor 1. (928 aa)
GDI1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (447 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (442 aa)
SEMA5ASemaphorin 5A. (1074 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (836 aa)
CTNNB1Catenin beta 1. (781 aa)
PCM1Pericentriolar material 1. (2073 aa)
DMTNDematin actin binding protein. (323 aa)
TRIM11Tripartite motif containing 11. (468 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LTFLactotransferrin; Belongs to the transferrin family. (747 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
NOTCH1Notch receptor 1. (2555 aa)
NFATC4Nuclear factor of activated T cells 4. (901 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
TLX2T cell leukemia homeobox 2. (284 aa)
ENSCSAP00000011735Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (178 aa)
PAEPProgestagen associated endometrial protein; Belongs to the calycin superfamily. Lipocalin family. (180 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (18%) [HD]