STRINGSTRING
PKHD1 PKHD1 ALOX15 ALOX15 CRKL CRKL SMAD3 SMAD3 SPOCK1 SPOCK1 PTPRA PTPRA PRKCE PRKCE AGR2 AGR2 FERMT1 FERMT1 CORO2B CORO2B JAG1 JAG1 SRC SRC PPM1F PPM1F CRK CRK DMD DMD HRG HRG ENSCSAP00000010271 ENSCSAP00000010271 SDC4 SDC4 WDPCP WDPCP PEAK1 PEAK1 ABL1 ABL1 MYADM MYADM FUT1 FUT1 ENSCSAP00000019137 ENSCSAP00000019137 ATXN3L ATXN3L FZD7 FZD7 PRKCZ PRKCZ AJAP1 AJAP1 PDPN PDPN RCC2 RCC2 CDC42 CDC42 WNT4 WNT4 SLC9A1 SLC9A1 COL16A1 COL16A1 MACF1 MACF1 TACSTD2 TACSTD2 CCN1 CCN1 CSF1 CSF1 S100A10 S100A10 ADAM15 ADAM15 TBCD TBCD RAC3 RAC3 LRRC45 LRRC45 P4HB P4HB RRAS RRAS THY1 THY1 SKAP1 SKAP1 CD3E CD3E CCR7 CCR7 CORO1C CORO1C JUP JUP FOXF1 FOXF1 MMP12 MMP12 FGG FGG FGA FGA FGB FGB ENSCSAP00000014535 ENSCSAP00000014535 FZD4 FZD4 ENSCSAP00000014408 ENSCSAP00000014408 CCDC80 CCDC80 BCL2 BCL2 ONECUT2 ONECUT2 ENSCSAP00000014056 ENSCSAP00000014056 SERPINE1 SERPINE1 ENSCSAP00000013783 ENSCSAP00000013783 RAC1 RAC1 OLFM4 OLFM4 ROCK1 ROCK1 ARHGEF7 ARHGEF7 MAP4K4 MAP4K4 UTRN UTRN CIB1 CIB1 LIMCH1 LIMCH1 LIMS1 LIMS1 ANGPT2 ANGPT2 EGFLAM EGFLAM ENSCSAP00000012988 ENSCSAP00000012988 DAB2 DAB2 LIMS2 LIMS2 ENSCSAP00000012858 ENSCSAP00000012858 CCL28 CCL28 CLASP1 CLASP1 EPB41L5 EPB41L5 DMTN DMTN BST1 BST1 DOCK5 DOCK5 PTK2B PTK2B CSPG5 CSPG5 VWC2 VWC2 PIK3R1 PIK3R1 NOTCH1 NOTCH1 CASS4 CASS4 PLEKHA2 PLEKHA2 ARHGAP6 ARHGAP6 EGFL6 EGFL6 EFNA5 EFNA5 SFRP1 SFRP1 RHOA RHOA GPM6B GPM6B TSC1 TSC1 DAG1 DAG1 FERMT2 FERMT2 PREX1 PREX1 EDIL3 EDIL3 RASA1 RASA1 GREM1 GREM1 NDNF NDNF ITGB3 ITGB3 AP1AR AP1AR MYF5 MYF5 DMP1 DMP1 HPSE HPSE DOCK1 DOCK1 UNC13D UNC13D CX3CL1 CX3CL1 KDR KDR ITGA3 ITGA3 COL1A1 COL1A1 SLK SLK FBLN1 FBLN1 ITGA5 ITGA5 LDB1 LDB1 HSD17B12 HSD17B12 MDK MDK ACVRL1 ACVRL1 PTPRJ PTPRJ EPHA3 EPHA3 BCAS3 BCAS3 COL8A1 COL8A1 ABI3BP ABI3BP WNT1 WNT1 PDGFB PDGFB CALR CALR PHLDB2 PHLDB2 NF1 NF1 FLNA FLNA FMN1 FMN1 PTEN PTEN DNM2 DNM2 ENSCSAP00000003244 ENSCSAP00000003244 TRIOBP TRIOBP GSK3B GSK3B ITGB1BP1 ITGB1BP1 NINJ1 NINJ1 EPHA1 EPHA1 DUSP22 DUSP22 ECM2 ECM2 THBS1 THBS1 ROCK2 ROCK2 POLDIP2 POLDIP2 RREB1 RREB1 MEN1 MEN1 GCNT2 GCNT2 NEDD9 NEDD9 RAC2 RAC2 ARL2 ARL2 CARMIL1 CARMIL1 EFEMP2 EFEMP2 ENSCSAP00000004411 ENSCSAP00000004411 BRAF BRAF DDR1 DDR1 PTPRO PTPRO CAMSAP3 CAMSAP3 SPOCK2 SPOCK2 EMP2 EMP2 KANK1 KANK1 MELTF MELTF APOD APOD JAK2 JAK2 ARPC2 ARPC2 TSTA3 TSTA3 PLAU PLAU VCL VCL BCL6 BCL6 FN1 FN1 ST6GAL1 ST6GAL1 ENSCSAP00000005586 ENSCSAP00000005586 CLASP2 CLASP2 ACER2 ACER2 FBLN2 FBLN2 EMILIN1 EMILIN1 PTK2 PTK2 ENSCSAP00000005944 ENSCSAP00000005944 NID1 NID1 TEK TEK EMID1 EMID1 CCL21 CCL21 DISC1 DISC1 TESK1 TESK1 TLN1 TLN1 DAPK3 DAPK3 HAS2 HAS2 NEXMIF NEXMIF PIK3CB PIK3CB ENSCSAP00000007525 ENSCSAP00000007525 NRP1 NRP1 RIN2 RIN2 MYOC MYOC VIT VIT CD36 CD36 VEGFA VEGFA SEMA3E SEMA3E SPRY4 SPRY4 RELL2 RELL2 CDK6 CDK6 HACD1 HACD1 RSU1 RSU1 C1QBP C1QBP MINK1 MINK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (2535 aa)
ALOX15Arachidonate 15-lipoxygenase. (610 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SPOCK1SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. (294 aa)
PTPRAProtein tyrosine phosphatase receptor type A. (881 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
FERMT1Fermitin family member 1. (677 aa)
CORO2BCoronin; Belongs to the WD repeat coronin family. (480 aa)
JAG1Jagged canonical Notch ligand 1. (1218 aa)
SRCTyrosine-protein kinase. (633 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (455 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
DMDUncharacterized protein. (774 aa)
HRGHistidine rich glycoprotein. (521 aa)
ENSCSAP00000010271ZZ-type domain-containing protein. (595 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
WDPCPWD repeat containing planar cell polarity effector. (713 aa)
PEAK1Pseudopodium enriched atypical kinase 1. (1746 aa)
ABL1Tyrosine-protein kinase. (1130 aa)
MYADMMyeloid associated differentiation marker. (322 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (366 aa)
ENSCSAP00000019137L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (357 aa)
ATXN3LAtaxin 3 like. (354 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. (488 aa)
AJAP1Adherens junctions associated protein 1. (409 aa)
PDPNPodoplanin. (162 aa)
RCC2Regulator of chromosome condensation 2. (552 aa)
CDC42Cell division cycle 42. (191 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
COL16A1LAM_G_DOMAIN domain-containing protein. (868 aa)
MACF1Microtubule actin crosslinking factor 1. (7557 aa)
TACSTD2Tumor associated calcium signal transducer 2. (339 aa)
CCN1Cellular communication network factor 1. (381 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (560 aa)
S100A10S_100 domain-containing protein; Belongs to the S-100 family. (199 aa)
ADAM15ADAM metallopeptidase domain 15. (754 aa)
TBCDTubulin folding cofactor D. (1192 aa)
RAC3Rac family small GTPase 3. (192 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
P4HBProtein disulfide-isomerase. (510 aa)
RRASRAS related. (218 aa)
THY1Thy-1 cell surface antigen. (161 aa)
SKAP1Src kinase associated phosphoprotein 1. (266 aa)
CD3ECD3e molecule. (197 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (483 aa)
JUPJunction plakoglobin. (745 aa)
FOXF1Forkhead box F1. (354 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
FGGFibrinogen gamma chain. (437 aa)
FGAFibrinogen alpha chain. (875 aa)
FGBFibrinogen beta chain. (491 aa)
ENSCSAP00000014535Uncharacterized protein. (344 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
ENSCSAP00000014408Rho-GAP domain-containing protein. (860 aa)
CCDC80Coiled-coil domain containing 80. (660 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ONECUT2One cut domain family member. (504 aa)
ENSCSAP00000014056Uncharacterized protein. (313 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
ENSCSAP00000013783Uncharacterized protein. (140 aa)
RAC1Rac family small GTPase 1. (192 aa)
OLFM4Olfactomedin 4. (508 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (862 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1382 aa)
UTRNUtrophin. (3434 aa)
CIB1Calcium and integrin binding 1. (191 aa)
LIMCH1LIM and calponin homology domains 1. (1107 aa)
LIMS1LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (337 aa)
ANGPT2Angiopoietin 2. (495 aa)
EGFLAMEGF like, fibronectin type III and laminin G domains. (1009 aa)
ENSCSAP00000012988BCAS3 domain-containing protein. (913 aa)
DAB2DAB adaptor protein 2. (770 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (341 aa)
ENSCSAP00000012858START domain-containing protein. (1078 aa)
CCL28C-C motif chemokine. (129 aa)
CLASP1Cytoplasmic linker associated protein 1. (1528 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (699 aa)
DMTNDematin actin binding protein. (323 aa)
BST1Bone marrow stromal cell antigen 1. (315 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1870 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1018 aa)
CSPG5Chondroitin sulfate proteoglycan 5. (562 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
NOTCH1Notch receptor 1. (2555 aa)
CASS4Cas scaffold protein family member 4. (786 aa)
PLEKHA2Pleckstrin homology domain containing A2. (425 aa)
ARHGAP6Rho GTPase activating protein 6. (736 aa)
EGFL6EGF like domain multiple 6. (553 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (197 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
RHOARas homolog family member A. (193 aa)
GPM6BGlycoprotein M6B. (330 aa)
TSC1TSC complex subunit 1. (1164 aa)
DAG1Dystroglycan 1. (894 aa)
FERMT2Fermitin family member 2. (507 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1661 aa)
EDIL3EGF like repeats and discoidin domains 3. (480 aa)
RASA1RAS p21 protein activator 1. (1047 aa)
GREM1Gremlin. (184 aa)
NDNFNeuron derived neurotrophic factor. (577 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (741 aa)
AP1ARAdaptor related protein complex 1 associated regulatory protein. (282 aa)
MYF5Myogenic factor 5. (255 aa)
DMP1Dentin matrix acidic phosphoprotein 1. (506 aa)
HPSEHeparanase. (546 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1330 aa)
UNC13DUnc-13 homolog D. (1071 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (402 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1049 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
SLKSTE20 like kinase. (1236 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (703 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1098 aa)
LDB1LIM domain binding 1. (411 aa)
HSD17B12Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
MDKUncharacterized protein. (159 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1333 aa)
EPHA3EPH receptor A3. (984 aa)
BCAS3BCAS3 domain-containing protein. (665 aa)
COL8A1Collagen type VIII alpha 1 chain. (746 aa)
ABI3BPABI family member 3 binding protein. (1753 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
CALRCalreticulin. (417 aa)
PHLDB2Pleckstrin homology like domain family B member 2. (1348 aa)
NF1Neurofibromin 1. (2849 aa)
FLNAFilamin A. (2639 aa)
FMN1Formin 1. (1291 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
ENSCSAP00000003244Uncharacterized protein. (124 aa)
TRIOBPTRIO and F-actin binding protein. (2192 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
NINJ1Ninjurin 1. (152 aa)
EPHA1EPH receptor A1. (979 aa)
DUSP22Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
ECM2Extracellular matrix protein 2. (677 aa)
THBS1Thrombospondin 1. (1170 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
POLDIP2DNA polymerase delta interacting protein 2. (408 aa)
RREB1Ras responsive element binding protein 1. (1742 aa)
MEN1Menin 1. (610 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (834 aa)
RAC2Rac family small GTPase 2. (192 aa)
ARL2ADP ribosylation factor like GTPase 2; Belongs to the small GTPase superfamily. Arf family. (184 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1424 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
ENSCSAP00000004411SCY domain-containing protein. (142 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (482 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (913 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1023 aa)
CAMSAP3Calmodulin regulated spectrin associated protein family member 3. (1260 aa)
SPOCK2SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (421 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
KANK1KN motif and ankyrin repeat domains 1. (1352 aa)
MELTFMelanotransferrin; Belongs to the transferrin family. (733 aa)
APODApolipoprotein D. (189 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
TSTA3Tissue specific transplantation antigen P35B. (321 aa)
PLAUPlasminogen activator, urokinase. (437 aa)
VCLVinculin. (1134 aa)
BCL6BCL6 transcription repressor. (708 aa)
FN1Fibronectin 1. (2265 aa)
ST6GAL1ST6 beta-galactoside alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (406 aa)
ENSCSAP00000005586Uncharacterized protein. (163 aa)
CLASP2Uncharacterized protein. (1552 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (226 aa)
FBLN2Fibulin 2. (1225 aa)
EMILIN1Elastin microfibril interfacer 1. (860 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1038 aa)
ENSCSAP00000005944Uncharacterized protein. (173 aa)
NID1Nidogen 1. (1249 aa)
TEKTEK receptor tyrosine kinase. (1123 aa)
EMID1EMI domain containing 1. (443 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
DISC1DISC1 scaffold protein. (639 aa)
TESK1Testis associated actin remodelling kinase 1. (626 aa)
TLN1Talin 1. (2558 aa)
DAPK3Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
HAS2Hyaluronan synthase 2. (552 aa)
NEXMIFNeurite extension and migration factor. (1516 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ENSCSAP00000007525Josephin domain-containing protein. (180 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
RIN2Ras and Rab interactor 2. (895 aa)
MYOCMyocilin. (491 aa)
VITVitrin. (696 aa)
CD36CD36 molecule; Belongs to the CD36 family. (473 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (395 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (715 aa)
SPRY4Sprouty RTK signaling antagonist 4. (322 aa)
RELL2RELT like 2. (276 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
HACD1Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (288 aa)
RSU1Ras suppressor protein 1. (277 aa)
C1QBPComplement C1q binding protein. (281 aa)
MINK1Misshapen like kinase 1. (1341 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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