STRINGSTRING
EED EED WNT3A WNT3A NOTCH1 NOTCH1 LOXL3 LOXL3 LHX3 LHX3 DCTN1 DCTN1 PROX1 PROX1 GLI3 GLI3 MDGA2 MDGA2 TBX20 TBX20 ISL2 ISL2 HOXD10 HOXD10 SOX13 SOX13 CHRD CHRD PBX3 PBX3 PLXDC2 PLXDC2 LHX4 LHX4 ZC4H2 ZC4H2 VIT VIT DLL1 DLL1 RELN RELN SCYL3 SCYL3 MED12 MED12 ZIC1 ZIC1 TULP3 TULP3 DAAM2 DAAM2 NKX2-2 NKX2-2 PKD1 PKD1 MDGA1 MDGA1 DRGX DRGX PTPRS PTPRS SMO SMO VLDLR VLDLR DMRT3 DMRT3 GATA2 GATA2 GDF7 GDF7 ABT1 ABT1 SCYL1 SCYL1 MPST MPST DLL4 DLL4 ADARB1 ADARB1 GBX1 GBX1 NF1 NF1 SHH SHH GIGYF2 GIGYF2 PTCH1 PTCH1 MNX1 MNX1 WNT1 WNT1 LHX1 LHX1 SLIT1 SLIT1 LBX1 LBX1 HOXC10 HOXC10 SUFU SUFU GDF11 GDF11 PAX6 PAX6 DBX1 DBX1 GSX2 GSX2 SOX6 SOX6 BAG3 BAG3 PKD2 PKD2 PHOX2A PHOX2A FOXB1 FOXB1 SOX4 SOX4 ASCL1 ASCL1 SOX12 SOX12 OLIG2 OLIG2 NEUROG3 NEUROG3 OLIG3 OLIG3 SOX11 SOX11 NOG NOG DRAXIN DRAXIN LRP8 LRP8 LMO4 LMO4 PTBP2 PTBP2 PHGDH PHGDH LHX5 LHX5 HOXB8 HOXB8 TCTN1 TCTN1 PLXDC1 PLXDC1 ZPR1 ZPR1 FOXN4 FOXN4 RFX4 RFX4 DYNC2H1 DYNC2H1 ERCC2 ERCC2 VSTM5 VSTM5 INTU INTU DCC DCC GSX1 GSX1 ACTL6B ACTL6B UNCX UNCX CLN8 CLN8 GDNF GDNF ISL1 ISL1 GLI2 GLI2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EEDEmbryonic ectoderm development. (441 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
NOTCH1Notch receptor 1. (2555 aa)
LOXL3Lysyl oxidase like 3. (753 aa)
LHX3LIM homeobox 3. (402 aa)
DCTN1CAP-Gly domain-containing protein. (1433 aa)
PROX1Prospero homeobox 1. (737 aa)
GLI3GLI family zinc finger 3. (1459 aa)
MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2. (932 aa)
TBX20T-box transcription factor 20. (447 aa)
ISL2ISL LIM homeobox 2. (359 aa)
HOXD10Homeobox D10. (340 aa)
SOX13SRY-box transcription factor 13. (621 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (956 aa)
PBX3Homeobox domain-containing protein. (326 aa)
PLXDC2Plexin domain containing 2. (338 aa)
LHX4LIM homeobox 4. (390 aa)
ZC4H2Zinc finger C4H2-type containing. (224 aa)
VITVitrin. (696 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
RELNReelin. (3427 aa)
SCYL3SCY1 like pseudokinase 3. (742 aa)
MED12Mediator complex subunit 12. (2090 aa)
ZIC1Zic family member 1. (447 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (442 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1068 aa)
NKX2-2NK2 homeobox 2. (273 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (3853 aa)
MDGA1MAM domain containing glycosylphosphatidylinositol anchor 1. (934 aa)
DRGXDorsal root ganglia homeobox. (263 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1941 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
VLDLRVery low density lipoprotein receptor. (873 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
GATA2GATA binding protein 2. (397 aa)
GDF7Growth differentiation factor 7. (447 aa)
ABT1Activator of basal transcription 1. (276 aa)
SCYL1SCY1 like pseudokinase 1. (808 aa)
MPSTSulfurtransferase. (317 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
ADARB1Adenosine deaminase RNA specific B1. (701 aa)
GBX1Gastrulation brain homeobox 1. (434 aa)
NF1Neurofibromin 1. (2849 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
GIGYF2GRB10 interacting GYF protein 2. (1232 aa)
PTCH1Patched 1. (1452 aa)
MNX1Motor neuron and pancreas homeobox 1. (401 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
LHX1LIM homeobox 1. (406 aa)
SLIT1Slit guidance ligand 1. (1396 aa)
LBX1Ladybird homeobox 1. (281 aa)
HOXC10Homeobox C10. (342 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
GDF11Growth differentiation factor 11. (406 aa)
PAX6Paired box 6. (436 aa)
DBX1Developing brain homeobox 1. (344 aa)
GSX2GS homeobox 2. (304 aa)
SOX6SRY-box transcription factor 6. (466 aa)
BAG3BCL2 associated athanogene 3. (575 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (859 aa)
PHOX2APaired like homeobox 2A. (284 aa)
FOXB1Forkhead box B1. (325 aa)
SOX4Transcription factor SOX. (475 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (239 aa)
SOX12Transcription factor SOX. (314 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
NEUROG3Neurogenin 3. (215 aa)
OLIG3Oligodendrocyte transcription factor 3. (273 aa)
SOX11Transcription factor SOX. (441 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
LRP8LDL receptor related protein 8. (1002 aa)
LMO4LIM domain only 4. (165 aa)
PTBP2Polypyrimidine tract binding protein 2. (531 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
LHX5LIM homeobox 5. (402 aa)
HOXB8Homeobox B8. (243 aa)
TCTN1Tectonic family member 1. (587 aa)
PLXDC1Plexin domain containing 1. (500 aa)
ZPR1ZPR1 zinc finger. (459 aa)
FOXN4Forkhead box N4. (517 aa)
RFX4Regulatory factor X4. (738 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4311 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (736 aa)
VSTM5V-set and transmembrane domain containing 5. (199 aa)
INTUInturned planar cell polarity protein. (921 aa)
DCCDCC netrin 1 receptor. (1420 aa)
GSX1GS homeobox 1. (264 aa)
ACTL6BActin like 6B; Belongs to the actin family. (426 aa)
UNCXUNC homeobox. (377 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (286 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
ISL1ISL LIM homeobox 1. (349 aa)
GLI2GLI family zinc finger 2. (1554 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.