STRINGSTRING
TBX20 TBX20 MDGA2 MDGA2 GLI3 GLI3 LHX3 LHX3 NOTCH1 NOTCH1 WNT3A WNT3A GLI2 GLI2 ISL1 ISL1 CLN8 CLN8 GSX1 GSX1 DYNC2H1 DYNC2H1 FOXN4 FOXN4 TCTN1 TCTN1 LHX5 LHX5 ZC4H2 ZC4H2 LMO4 LMO4 PHOX2A PHOX2A SOX6 SOX6 GSX2 GSX2 DBX1 DBX1 SUFU SUFU HOXC10 HOXC10 LBX1 LBX1 LHX1 LHX1 WNT1 WNT1 MNX1 MNX1 PTCH1 PTCH1 GIGYF2 GIGYF2 SHH SHH GBX1 GBX1 DLL4 DLL4 SCYL1 SCYL1 ABT1 ABT1 GDF7 GDF7 GATA2 GATA2 DMRT3 DMRT3 MDGA1 MDGA1 NKX2-2 NKX2-2 SCYL3 SCYL3 LHX4 LHX4 SOX13 SOX13 HOXD10 HOXD10 ISL2 ISL2 SOX4 SOX4 ASCL1 ASCL1 OLIG2 OLIG2 OLIG3 OLIG3 DRAXIN DRAXIN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBX20T-box transcription factor 20. (447 aa)
MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2. (932 aa)
GLI3GLI family zinc finger 3. (1459 aa)
LHX3LIM homeobox 3. (402 aa)
NOTCH1Notch receptor 1. (2555 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
GLI2GLI family zinc finger 2. (1554 aa)
ISL1ISL LIM homeobox 1. (349 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (286 aa)
GSX1GS homeobox 1. (264 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4311 aa)
FOXN4Forkhead box N4. (517 aa)
TCTN1Tectonic family member 1. (587 aa)
LHX5LIM homeobox 5. (402 aa)
ZC4H2Zinc finger C4H2-type containing. (224 aa)
LMO4LIM domain only 4. (165 aa)
PHOX2APaired like homeobox 2A. (284 aa)
SOX6SRY-box transcription factor 6. (466 aa)
GSX2GS homeobox 2. (304 aa)
DBX1Developing brain homeobox 1. (344 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
HOXC10Homeobox C10. (342 aa)
LBX1Ladybird homeobox 1. (281 aa)
LHX1LIM homeobox 1. (406 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
MNX1Motor neuron and pancreas homeobox 1. (401 aa)
PTCH1Patched 1. (1452 aa)
GIGYF2GRB10 interacting GYF protein 2. (1232 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
GBX1Gastrulation brain homeobox 1. (434 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (663 aa)
SCYL1SCY1 like pseudokinase 1. (808 aa)
ABT1Activator of basal transcription 1. (276 aa)
GDF7Growth differentiation factor 7. (447 aa)
GATA2GATA binding protein 2. (397 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (472 aa)
MDGA1MAM domain containing glycosylphosphatidylinositol anchor 1. (934 aa)
NKX2-2NK2 homeobox 2. (273 aa)
SCYL3SCY1 like pseudokinase 3. (742 aa)
LHX4LIM homeobox 4. (390 aa)
SOX13SRY-box transcription factor 13. (621 aa)
HOXD10Homeobox D10. (340 aa)
ISL2ISL LIM homeobox 2. (359 aa)
SOX4Transcription factor SOX. (475 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (239 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
OLIG3Oligodendrocyte transcription factor 3. (273 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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