STRINGSTRING
BMP7 BMP7 PROX1 PROX1 TGFB2 TGFB2 LAMA5 LAMA5 NOTCH1 NOTCH1 NKX3-1 NKX3-1 ARG1 ARG1 FGL1 FGL1 FGF10 FGF10 EDAR EDAR ENSCSAP00000013048 ENSCSAP00000013048 CSMD1 CSMD1 TGFBR2 TGFBR2 DUOX2 DUOX2 PHB2 PHB2 NTN1 NTN1 FGF7 FGF7 CAV1 CAV1 NRP1 NRP1 CSF1R CSF1R EDA EDA AR AR SEMA3C SEMA3C MSN MSN TGFB3 TGFB3 WNT5A WNT5A TNC TNC LRRC1 LRRC1 SOSTDC1 SOSTDC1 FEM1B FEM1B SRC SRC TGM2 TGM2 IL6 IL6 ELF3 ELF3 PML PML KDM5B KDM5B ESR1 ESR1 CYP7B1 CYP7B1 HOXA13 HOXA13 HOXD13 HOXD13 PLAG1 PLAG1 BMP4 BMP4 MST1 MST1 DAG1 DAG1 POLB POLB SFRP1 SFRP1 BCL2 BCL2 ENSCSAP00000013601 ENSCSAP00000013601 SERPINB5 SERPINB5 TGFB1 TGFB1 MED1 MED1 HOXB13 HOXB13 BSX BSX TBX3 TBX3 NOTCH2 NOTCH2 CSF1 CSF1 CSMD2 CSMD2 RPS6KA1 RPS6KA1 WNT4 WNT4 EPHA2 EPHA2 NOG NOG CEBPB CEBPB TWSG1 TWSG1 NFKB1 NFKB1 ESRP2 ESRP2 FRS2 FRS2 SOX9 SOX9 MKI67 MKI67 FGFR2 FGFR2 AREG AREG STAT6 STAT6 PAX6 PAX6 MMP2 MMP2 FGF8 FGF8 RARG RARG BTRC BTRC NKX2-3 NKX2-3 TBX2 TBX2 PTCH1 PTCH1 SHH SHH VDR VDR ID4 ID4 CUL3 CUL3 GDF7 GDF7 PLXNA1 PLXNA1 DDR1 DDR1 SCRIB SCRIB LRP5 LRP5 TP63 TP63 IGFBP5 IGFBP5 PLXND1 PLXND1 NFIB NFIB CRIP1 CRIP1 NRG3 NRG3 TGFA TGFA GLI3 GLI3 FOXA1 FOXA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP7Bone morphogenetic protein 7. (431 aa)
PROX1Prospero homeobox 1. (737 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
LAMA5Laminin subunit alpha 5. (3694 aa)
NOTCH1Notch receptor 1. (2555 aa)
NKX3-1NK3 homeobox 1. (232 aa)
ARG1Arginase. (322 aa)
FGL1Fibrinogen like 1. (312 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
EDAREctodysplasin A receptor. (450 aa)
ENSCSAP00000013048Uncharacterized protein. (152 aa)
CSMD1Uncharacterized protein. (1618 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
DUOX2Dual oxidase 2. (1552 aa)
PHB2Prohibitin. (288 aa)
NTN1Netrin 1. (604 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (260 aa)
ARAndrogen receptor. (900 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
MSNMoesin. (577 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TNCTenascin C. (2201 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
FEM1BUncharacterized protein. (564 aa)
SRCTyrosine-protein kinase. (633 aa)
TGM2Transglutaminase 2. (687 aa)
IL6Interleukin 6. (212 aa)
ELF3E74 like ETS transcription factor 3. (371 aa)
PMLPromyelocytic leukemia. (819 aa)
KDM5BLysine demethylase 5B. (1544 aa)
ESR1Estrogen receptor 1. (487 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (436 aa)
HOXA13Homeobox A13. (391 aa)
HOXD13Homeobox D13. (343 aa)
PLAG1PLAG1 zinc finger. (500 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
DAG1Dystroglycan 1. (894 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
ENSCSAP00000013601Uncharacterized protein. (637 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (375 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
HOXB13Homeobox B13. (284 aa)
BSXBrain specific homeobox. (232 aa)
TBX3T-box transcription factor 3. (723 aa)
NOTCH2Notch receptor 2. (2471 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (560 aa)
CSMD2CUB and Sushi multiple domains 2. (3463 aa)
RPS6KA1Ribosomal protein S6 kinase. (735 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
EPHA2EPH receptor A2. (1033 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
CEBPBCCAAT/enhancer-binding protein. (344 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
ESRP2Epithelial splicing regulatory protein 2. (715 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
SOX9SRY-box transcription factor 9. (509 aa)
MKI67Marker of proliferation Ki-67. (3251 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
AREGAmphiregulin. (252 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
PAX6Paired box 6. (436 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
RARGRetinoic acid receptor gamma. (443 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
NKX2-3NK2 homeobox 3. (319 aa)
TBX2T-box transcription factor 2. (588 aa)
PTCH1Patched 1. (1452 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (465 aa)
VDRVitamin D receptor. (434 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
GDF7Growth differentiation factor 7. (447 aa)
PLXNA1Plexin A1. (1916 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (913 aa)
SCRIBScribble planar cell polarity protein. (1678 aa)
LRP5LDL receptor related protein 5. (1451 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (500 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
PLXND1Plexin D1. (1833 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
CRIP1LIM zinc-binding domain-containing protein. (77 aa)
NRG3Uncharacterized protein. (376 aa)
TGFATransforming growth factor alpha. (158 aa)
GLI3GLI family zinc finger 3. (1459 aa)
FOXA1Forkhead box A1. (470 aa)
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (22%) [HD]